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Method for preparing fluoridated hydroxyapatite by one step

A technology of fluorinated hydroxyapatite and potassium fluoride, which is applied in chemical instruments and methods, phosphorus compounds, inorganic chemistry, etc., to achieve the effects of reduced preparation costs, simple process flow, and low price

Inactive Publication Date: 2016-01-27
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the reaction synthesis method adopted in this technology uses more raw materials, which inevitably brings a certain amount of by-products.

Method used

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  • Method for preparing fluoridated hydroxyapatite by one step
  • Method for preparing fluoridated hydroxyapatite by one step
  • Method for preparing fluoridated hydroxyapatite by one step

Examples

Experimental program
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Effect test

Embodiment 1

[0027] This embodiment includes the following steps: dissolving 0.02 mol of calcium hydrogen phosphate dihydrate in 200 mL of ultrapure water, and electromagnetically stirring for 30 minutes to form a uniform suspension. Dissolve 0.02mol potassium fluoride dihydrate in 120mL ultrapure water, and stir with a glass rod to form a uniform solution. The potassium fluoride solution was added dropwise to the calcium hydrogen phosphate solution at a rate of 0.05mL / s, and the electromagnetic stirring was continued, and the upper opening of the reaction vessel was covered and sealed, and reacted at room temperature for 4 hours, and then stood still for 12 hours. The precipitate was washed and dried at 80° C. for 3 hours to obtain fluorinated hydroxyapatite.

Embodiment 2

[0029] This embodiment includes the following steps: dissolving 0.02 mol of calcium hydrogen phosphate dihydrate in 200 mL of ultrapure water, and electromagnetically stirring for 30 minutes to form a uniform suspension. Dissolve 0.004mol potassium fluoride dihydrate in 120mL ultrapure water, and stir with a glass rod to form a uniform solution. Potassium fluoride solution was added dropwise to the calcium hydrogen phosphate solution at a rate of 0.05mL / s, and the solution was mixed continuously under electromagnetic stirring, and the upper opening of the reaction vessel was covered and closed, and reacted at room temperature for 4 hours, and then stood still for 12 hours. The precipitate was washed and dried at 80°C to obtain fluorinated hydroxyapatite.

Embodiment 3

[0031] Dissolve 0.02mol of calcium hydrogen phosphate dihydrate in 200mL of ultrapure water, and stir it electromagnetically for 30 minutes to form a uniform suspension. Dissolve 0.0033mol potassium fluoride dihydrate in 120mL ultrapure water, and stir with a glass rod to form a uniform solution. Potassium fluoride solution was added dropwise to the calcium hydrogen phosphate solution at a rate of 0.05mL / s, and the solution was mixed continuously under electromagnetic stirring, and the upper opening of the reaction vessel was covered and closed, and reacted at room temperature for 4 hours, and then stood still for 12 hours. The precipitate was washed and dried at 80°C to obtain fluorinated hydroxyapatite and a small amount of calcium hydrogen phosphate.

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Abstract

The invention discloses a method for preparing fluoridated hydroxyapatite by one step. The method comprises the following steps that calcium hydrogen phosphate dihydrate and potassium fluoride dihydrate are respectively prepared into uniformly mixed solutions or suspensions; at the room temperature, the potassium fluoride dihydrate solution is dripped into the calcium hydrogen phosphate dihydrate suspension to form mixed liquid; after the mixture is placed still and dried, the fluoridated hydroxyapatite (FHA) is obtained. An apatite synthesizing process and a fluorination synthesizing process are combined into one step, and the pH value is not required to be adjusted, and the fluoridated hydroxyapatite is obtained through a single-step reaction synthesis under the room-temperature condition. The method is simple in process flow, available in raw material source, and low in price of raw materials, and complex equipment is not required during reaction, so that the preparation cost of the fluoridated hydroxyapatite is greatly reduced.

Description

technical field [0001] The invention relates to a technology in the field of biological material preparation, in particular to a fast and simple method for directly synthesizing fluorinated hydroxyapatite in a single step from a calcium hydrogen phosphate sample. Background technique [0002] Fluorinated hydroxyapatite (FHA) is the OH in hydroxyapatite (HA) - By F - Formed by partial substitution, the chemical formula is: Ca 10 (PO 4 ) 6 (OH) 2-2x f 2x , 0<x<1. The substituted fluorinated hydroxyapatite has a denser crystal structure and improved stability. Fluorinated hydroxyapatite has low solubility, good biocompatibility, and can release fluoride ions in body fluids, making it have better osteoinductive ability and antibacterial effect, so it is a good bone substitute material. Studies have shown that fluorine can improve the physical and biological properties of HA and help treat osteoporosis. The release content of fluoride ions can be controlled by the ...

Claims

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Application Information

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IPC IPC(8): C01B25/455
Inventor 饶群力郭晓亮
Owner SHANGHAI JIAO TONG UNIV
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