Hydrothermal synthesis preparation method of zinc doped superparamagnetic ferroferric oxide nano particle

A technology of ferroferric oxide and nanoparticles, which is applied in the field of nano-biomedical materials, can solve the problems of low product crystallinity and low magnetic saturation value, and achieve the effect of simple preparation method, high crystallinity, and satisfying production and application

Active Publication Date: 2016-01-27
智玺那诺(上海)生物科技有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But in many cases, the crystallinity of the product obtained by these synthetic methods is low, and the magnetic saturation value is not high (Advanced Functional Materials, 2006,16,1805

Method used

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  • Hydrothermal synthesis preparation method of zinc doped superparamagnetic ferroferric oxide nano particle
  • Hydrothermal synthesis preparation method of zinc doped superparamagnetic ferroferric oxide nano particle
  • Hydrothermal synthesis preparation method of zinc doped superparamagnetic ferroferric oxide nano particle

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Effect test

Embodiment 1

[0025] FeSO 4 ·(NH 4 ) 2 SO 4 ·6H 2 O and ZnSO 4 Dissolve in 20ml of water so that the precursor reaches 1.73×10 -3 molFe 2+ and2.67×10 -4 mol Zn 2+ the goal of. Next, mix 10ml of oleic acid, 10ml of water and 1g of NaOH, and stir magnetically at room temperature until a homogeneous solution is obtained. Furthermore, the precursor Fe 2+ and Zn 2+ Pour into this homogeneous solution, and after stirring for a few minutes, the mixed solution turns dark brown. Finally, the solution was transferred into a 50ml reaction kettle, sealed, and heated at 230 degrees for 15 hours. After the reaction, cool to room temperature. The product is deposited at the bottom of the kettle, and the nanoparticles are taken out by dissolving with cyclohexane. Then add ethanol into the cyclohexane containing the nanoparticles to precipitate the nanoparticles, and finally wash the nanoparticles repeatedly with ethanol several times. The organic surfactant on the particle surface was double...

Embodiment 2

[0027] FeSO 4 ·(NH 4 ) 2 SO4 ·6H 2 O and ZnSO 4 Dissolve in 20ml of water so that the precursor reaches 1.87×10 -3 molFe 2+ and1.33×10 -4 mol Zn 2+ the goal of. Next, mix 10ml of oleic acid, 10ml of water and 1g of NaOH, and stir magnetically at room temperature until a homogeneous solution is obtained. Furthermore, the precursor Fe 2+ and Zn 2+ Pour into this homogeneous solution, and after stirring for a few minutes, the mixed solution turns dark brown. Finally, the solution was transferred into a 50ml reaction kettle, sealed, and heated at 230 degrees for 15 hours. After the reaction, cool to room temperature. The product is deposited at the bottom of the kettle, and the nanoparticles are taken out by dissolving with cyclohexane. Then add ethanol into the cyclohexane containing the nanoparticles to precipitate the nanoparticles, and finally wash the nanoparticles repeatedly with ethanol several times. The organic surfactant on the particle surface was double-e...

Embodiment 3

[0029] FeSO 4 ·(NH 4 ) 2 SO 4 ·6H 2 O and ZnSO 4 Dissolve in 20ml of water so that the precursor reaches 1.67×10 -3 molFe 2+ and3.33×10 -4 mol Zn 2+ the goal of. Next, mix 10ml of oleic acid, 10ml of water and 1g of NaOH, and stir magnetically at room temperature until a homogeneous solution is obtained. Furthermore, the precursor Fe 2+ and Zn 2+ Pour into this homogeneous solution, and after stirring for a few minutes, the mixed solution turns dark brown. Finally, the solution was transferred into a 50ml reaction kettle, sealed, and heated at 230 degrees for 15 hours. After the reaction, cool to room temperature. The product is deposited at the bottom of the kettle, and the nanoparticles are taken out by dissolving with cyclohexane. Then add ethanol into the cyclohexane containing the nanoparticles to precipitate the nanoparticles, and finally wash the nanoparticles repeatedly with ethanol several times. The organic surfactant on the particle surface was double...

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Abstract

The invention relates to a hydrothermal synthesis preparation method of zinc doped superparamagnetic ferroferric oxide. Particularly, a zinc doped ferroferric oxide nano particle with a high magnetic saturation value, high crystallinity, uniform particle size and biocompatibility is prepared by utilizing simple and economical reaction raw materials and a hydrothermal synthesis method and controlling reaction temperature, reaction time and different quantities of doped zinc elements. The nano particle prepared by the method has the high magnetic saturation value. The nano particle prepared by the method has the high crystallinity, uniform particle size and good physical-chemical stability. The nano particle contains Fe and Zn elements and has better biocompatibility. The particle as a magnetic nanomaterial can be widely applied to the biomedical field. The reaction raw materials in the preparation method are cheap, and the preparation method is simple in technology and strong in operability and can further meet production and application.

Description

technical field [0001] The present invention relates to a preparation method of zinc-doped superparamagnetic ferroferric oxide, specifically adopting a simple and economical hydrothermal synthesis method to prepare zinc-doped ferroferric oxide with high magnetic saturation value, high crystallinity and uniform particle size TriFe nanoparticles. The invention belongs to the field of nano biomedical materials. Background technique [0002] Superparamagnetic iron oxide nanoparticles (SPIONs) can provide many applications in biomedicine, such as: bioimaging, targeted drug carrier delivery, biosensors, anti-cancer thermal therapy, tissue and organ repair, and cell screening, etc. These applications mainly take advantage of the good chemical stability and magnetic response properties of SPIONs. Under the action of an external magnetic field, using SPIONs as drug carriers, anticancer drugs may pass through the vascular system and specifically reach the tumor site, thereby reducin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01G49/08B82Y30/00
Inventor 何丹农祝闪闪王萍
Owner 智玺那诺(上海)生物科技有限责任公司
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