A preparation method for hydrothermal synthesis of zinc-doped superparamagnetic ferric oxide nanoparticles

A technology of triiron tetroxide and nanoparticles, applied in the field of nano biomedical materials, can solve the problems of low magnetic saturation value and low crystallinity of products, achieve high crystallinity, simple preparation method and process, and meet the requirements of production and application. Effect

Active Publication Date: 2017-01-18
智玺那诺(上海)生物科技有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But in many cases, the crystallinity of the product obtained by these synthesis methods is low, and the magnetic saturation value is not high (Advanced Functional Materials, 2006,16,1805

Method used

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  • A preparation method for hydrothermal synthesis of zinc-doped superparamagnetic ferric oxide nanoparticles
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  • A preparation method for hydrothermal synthesis of zinc-doped superparamagnetic ferric oxide nanoparticles

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Embodiment 1

[0025] First put FeSO 4 ·(NH 4 ) 2 SO 4 ·6H 2 O and ZnSO 4 Dissolve in 20ml of water to make the precursor reach 1.73×10 -3 mol Fe 2+ and 2.67×10 -4 mol Zn 2+ the goal of. Next, mix 10 ml of oleic acid, 10 ml of water and 1 g of NaOH, and magnetically stir at room temperature until a uniform solution is obtained. Furthermore, the precursor Fe 2+ And Zn 2+ Pour into the homogeneous solution and stir for a few minutes, the mixed solution turns dark brown. Finally, the solution was transferred into a 50ml reactor, sealed, and heated at 230 degrees for 15 hours. After the reaction, it was cooled to room temperature. The product is deposited on the bottom of the kettle, and the nanoparticles are taken out by dissolving with cyclohexane. Then ethanol was added to the cyclohexane containing the nanoparticles to precipitate the nanoparticles, and finally the nanoparticles were washed several times with ethanol. The organic surfactant on the surface of the particles is double exch...

Embodiment 2

[0027] First put FeSO 4 ·(NH 4 ) 2 SO 4 ·6H 2 O and ZnSO 4 Dissolve in 20ml of water to make the precursor reach 1.87×10 -3 mol Fe 2+ and 1.33×10 -4 mol Zn 2+ the goal of. Next, mix 10 ml of oleic acid, 10 ml of water and 1 g of NaOH, and magnetically stir at room temperature until a uniform solution is obtained. Furthermore, the precursor Fe 2+ And Zn 2+ Pour into the homogeneous solution and stir for a few minutes, the mixed solution turns dark brown. Finally, the solution was transferred into a 50ml reactor, sealed, and heated at 230 degrees for 15 hours. After the reaction, it was cooled to room temperature. The product is deposited on the bottom of the kettle, and the nanoparticles are taken out by dissolving with cyclohexane. Then ethanol was added to the cyclohexane containing the nanoparticles to precipitate the nanoparticles, and finally the nanoparticles were washed several times with ethanol. The organic surfactant on the surface of the particles is double exch...

Embodiment 3

[0029] First put FeSO 4 ·(NH 4 ) 2 SO 4 ·6H 2 O and ZnSO 4 Dissolve in 20ml of water to make the precursor reach 1.67×10 -3 mol Fe 2+ and 3.33×10 -4 mol Zn 2+ the goal of. Next, mix 10 ml of oleic acid, 10 ml of water and 1 g of NaOH, and magnetically stir at room temperature until a uniform solution is obtained. Furthermore, the precursor Fe 2+ And Zn 2+ Pour into the homogeneous solution and stir for a few minutes, the mixed solution turns dark brown. Finally, the solution was transferred into a 50ml reactor, sealed, and heated at 230 degrees for 15 hours. After the reaction, it was cooled to room temperature. The product is deposited on the bottom of the kettle, and the nanoparticles are taken out by dissolving with cyclohexane. Then ethanol was added to the cyclohexane containing the nanoparticles to precipitate the nanoparticles, and finally the nanoparticles were washed several times with ethanol. The organic surfactant on the surface of the particles is double exch...

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Abstract

The invention relates to a hydrothermal synthesis preparation method of zinc doped superparamagnetic ferroferric oxide. Particularly, a zinc doped ferroferric oxide nano particle with a high magnetic saturation value, high crystallinity, uniform particle size and biocompatibility is prepared by utilizing simple and economical reaction raw materials and a hydrothermal synthesis method and controlling reaction temperature, reaction time and different quantities of doped zinc elements. The nano particle prepared by the method has the high magnetic saturation value. The nano particle prepared by the method has the high crystallinity, uniform particle size and good physical-chemical stability. The nano particle contains Fe and Zn elements and has better biocompatibility. The particle as a magnetic nanomaterial can be widely applied to the biomedical field. The reaction raw materials in the preparation method are cheap, and the preparation method is simple in technology and strong in operability and can further meet production and application.

Description

Technical field [0001] The invention relates to a method for preparing zinc-doped superparamagnetic ferroferric oxide, in particular to adopt a simple and economical hydrothermal synthesis method to prepare zinc-doped zinc tetroxide with high magnetic saturation value, high crystallinity and uniform particle size Three iron nanoparticles. The invention belongs to the field of nano biomedical materials. Background technique [0002] Superparamagnetic iron oxide nanoparticles (SPIONs) can provide many applications in biomedicine, such as: bioimaging, targeted drug carrier transportation, biosensors, anti-cancer thermal therapy, tissue and organ repair, and cell screening. These applications mainly utilize the better chemical stability and magnetic response properties of SPIONs. Under the action of an external magnetic field, using SPIONs as drug carriers, anticancer drugs may pass through the vascular system and specifically reach the tumor location, thereby reducing the damage t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C01G49/08B82Y30/00
Inventor 何丹农祝闪闪王萍
Owner 智玺那诺(上海)生物科技有限责任公司
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