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Application of Resolvin D1 as antiepileptic drugs

An antiepileptic drug and antiepileptic technology, applied in the field of biomedicine

Inactive Publication Date: 2016-02-03
THE FIRST AFFILIATED HOSPITAL OF XIAN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, whether ResolvinD1 has a protective effect on brain tissue damage caused by epilepsy has not been reported at home and abroad.

Method used

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  • Application of Resolvin D1 as antiepileptic drugs
  • Application of Resolvin D1 as antiepileptic drugs
  • Application of Resolvin D1 as antiepileptic drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0017] The present invention will be described in detail below in combination with specific embodiments.

[0018] The invention relates to the brain protection effect and mechanism of 3 μg / kg ResolvinD1 on epileptic rats. The ResolvinD1 has anti-epileptic effect on epileptic rats induced by lithium chloride pilocarpine, and has anti-inflammatory response properties. The mechanism may be to significantly increase the expression of DEL1, reduce the content of IL-17 and other ways to reduce the inflammatory response in epileptic rats , to produce brain protection in epileptic rats.

[0019] ResolvinD1 has anti-inflammatory and anti-epileptic effects experiments:

[0020] 1. Case (sample) selection method:

[0021] Human cerebrospinal fluid and serum: A total of 35 patients who met the inclusion criteria and were admitted to the Neurology Department of the First Affiliated Hospital of Xi'an Medical College from December 2013 to December 2014 were collected and divided into an ep...

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PUM

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Abstract

The invention relates to application of Resolvin D1 as antiepileptic drugs. Resolvin D1 has high-efficiency inflammation resistance and inflammation absorption promotion effects, but currently no relevant reports are seen at home and abroad for whether Resolvin D1 has an effect on protecting brain tissue against damage caused by epilepsy or not. According to the application of Resolvin D1 as epilepsy treating drugs, Resolvin D1 serves as anti-inflammation and antiepileptic drugs by adding expression of endogenous anti-adhesion molecules DEL-1 and reducing the content of IL-17.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and specifically relates to the application of ResolvinD1 as an antiepileptic drug. Background technique [0002] Epilepsy is the second most common disease of the nervous system after stroke. About 50 million people in the world suffer from epilepsy, and there are more than 9 million epilepsy patients in my country, with more than 400,000 new cases each year. The treatment of epilepsy still takes drugs as the main means. Among them, traditional antiepileptic drugs include phenytoin, carbamazepine, valproic acid, phenobarbital, primidone, ethosuximide, and clonazepam; Epilepsy drugs include topiramate, lamotrigine, gabapentin, felbamate, oxcarbazepine, vigabatrin, tigabine, zonisamide, levetiracetam, and pregabalin. About 75-80% of patients can be controlled with the above antiepileptic drugs, but there are still 25-30% of epilepsy patients who are ineffective in drug treatment. This not only...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/232A61P25/08A61P29/00
Inventor 李亚军孟芳霖
Owner THE FIRST AFFILIATED HOSPITAL OF XIAN MEDICAL UNIV