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Prussian blue nano-particle contrast agent, preparation method and application thereof

A nanoparticle, Prussian blue technology, applied in the field of biomedical materials, can solve the problems of insolubility in water and limited application, and achieve the effect of simple operation, high repeatability, and good photothermal stability.

Inactive Publication Date: 2016-02-03
SHENZHEN INST OF ADVANCED TECH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The other is Fe 4 [Fe(CN) 6 ] 3 , the disadvantage of this Prussian blue nanoparticle is that it is insoluble in water, thus limiting its application in vivo

Method used

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  • Prussian blue nano-particle contrast agent, preparation method and application thereof
  • Prussian blue nano-particle contrast agent, preparation method and application thereof

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Embodiment 1

[0049] This embodiment provides a method for preparing a Prussian blue nanoparticle contrast agent, wherein the method includes the following steps:

[0050] 284 mg of ammonium ferrocyanide and 400 mg of citric acid are dissolved in 50 ml of water to form solution A. The concentration of ammonium ferrocyanide in solution A is 0.006 g / ml, and the concentration of citric acid is 0.008 g / ml;

[0051] 322 milligrams of ferric chloride, 400 milligrams of citric acid are dissolved in 50 milliliters of water to form solution B, the concentration of ferric chloride in solution B is 0.006 g / ml, and the concentration of citric acid is 0.008 g / ml;

[0052] Add 7 milliliters of polyethylene glycol with a molecular weight of 400 into solution A, and mix well to obtain solution C;

[0053] Add solution B to solution C and mix well to obtain solution D;

[0054] Transfer solution D to a stainless steel autoclave with polytetrafluoroethylene lining, put the autoclave into an oven, set the ...

Embodiment 2

[0058] This embodiment provides a method for preparing a Prussian blue nanoparticle contrast agent, wherein the method includes the following steps:

[0059] 368 mg of potassium ferrocyanide and 400 mg of citric acid are dissolved in 50 ml of ethanol to form solution A. In solution A, the concentration of potassium ferrocyanide is 0.007 g / ml, and the concentration of citric acid is 0.008 g / ml;

[0060] 300 mg of ferrous chloride and 400 mg of citric acid are dissolved in 50 ml of ethanol to form solution B, the concentration of ferrous chloride in solution B is 0.005 g / ml, and the concentration of citric acid is 0.008 g / ml;

[0061] Add 7 milliliters of polyethylene glycol with a molecular weight of 400 into solution A, and mix well to obtain solution C;

[0062] Add solution B to solution C and mix well to obtain solution D;

[0063] Transfer solution D to a stainless steel autoclave with polytetrafluoroethylene lining, put the autoclave into an oven, set the temperature ...

Embodiment 3

[0067] This embodiment provides a method for preparing a Prussian blue nanoparticle contrast agent, wherein the method includes the following steps:

[0068] Dissolve 250 mg of sodium ferrocyanide and 400 mg of citric acid in 50 ml of ethylene glycol to form solution A. In solution A, the concentration of sodium ferrocyanide is 0.005 g / ml, and citric acid The concentration is 0.008 g / ml;

[0069] 322 mg of ferric chloride and 400 mg of citric acid are dissolved in 50 ml of ethylene glycol to form solution B. In solution B, the concentration of ferric chloride is 0.006 g / ml, and the concentration of citric acid is 0.008 g / ml;

[0070] Add 7 milliliters of polyethylene glycol with a molecular weight of 400 into solution A, and mix well to obtain solution C;

[0071] Add solution B to solution C and mix well to obtain solution D;

[0072] Transfer solution D to a stainless steel autoclave with polytetrafluoroethylene lining, put the autoclave into an oven, set the temperature ...

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Abstract

The invention provides a prussian blue nano-particle contrast agent, a preparation method and application thereof. The contrast agent includes a core of prussian blue nano-particle and a polyethylene glycol shell clad on the surface of prussian blue nano-particle. The preparation method of the contrast agent comprises dissolving hexacyanoferrate and organic acid in a solvent to obtain solution A; dissolving ferric chloride or ferrous chloride and organic acid in a solvent to obtain solution B; adding polyethylene glycol into the solution A to obtain solution C; adding the solution B into the solution C to obtain solution D; performing solvothermal synthesis reaction of the solution D, drying the solid product obtained by the reaction to obtain the prussian blue nano-particle contrast agent. The prussian blue nano-particle contrast agent has good water solubility and biocompatibility, and is benefit for the application in vivo.

Description

technical field [0001] The invention relates to a Prussian blue nanoparticle contrast agent and a preparation method and application thereof, belonging to the technical field of biomedical materials. Background technique [0002] With the needs of biomedical research and diagnosis, the technology of bioimaging using nanomaterials has attracted more and more attention. Bioimaging techniques mainly include optical imaging, magnetic resonance imaging, ultrasound imaging and positron imaging. Among them, optical imaging has the characteristics of high sensitivity and short detection time, but it has limitations in deep tissue imaging, while magnetic resonance imaging is a non-invasive imaging diagnostic method that can image deep tissues, but its sensitivity is not as good as optical imaging. . These two imaging techniques are very complementary. Photoacoustic imaging is a new non-invasive imaging technology developed in recent years. Its principle is to use the principle of ...

Claims

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Application Information

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IPC IPC(8): A61K49/12A61K49/18A61K49/00
Inventor 张华娟陈健桦宋亮
Owner SHENZHEN INST OF ADVANCED TECH CHINESE ACAD OF SCI
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