Method for producing sodium copper chlorophyllin through supercritical purification

A sodium copper chlorophyllin, supercritical technology, applied in the production of bulk chemicals, organic chemistry, etc., can solve the problems of inability to use supercritical purification, improve product quality and food and medicine safety, high selectivity, and increase yield Effect

Inactive Publication Date: 2016-02-03
SHANDONG GUANGTONGBAO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to solve the problem that supercritical purification cannot be adopted due to the particularity of the molecular structure of chlorophyll and its derivatives, or even if the yield of purification is extremely low, and a method for producing sodium copper chlorophyllin by supercritical purification is provided. The supercritical technology is used to purify copperized chlorophyll, which overcomes the particularity of the molecular structure of chlorophyll derivatives, greatly improves the yield of copperized chlorophyll, and makes the process of producing sodium copper chlorophyllin efficient and environmentally friendly.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] A method for producing sodium copper chlorophyllin by supercritical purification, comprising the following steps:

[0035] (1) saponification: first adding 2 to 6 parts by weight of ethanol solvent in 1 part of pasty chlorophyll for dissolving, wherein the mass fraction of chlorophyll in the pasty chlorophyll is 12%, and the water content is 23%; Then add the liquid caustic soda that is 0.3~0.8 parts by weight and keep saponification reaction at 60 DEG C for 1 hour;

[0036] (2) Washing: the saponified chlorophyll is extracted and washed 3 times with gasoline;

[0037] (3) Copperization: add copper chloride that is 0.1 part by weight to the saponified chlorophyll after washing, insulate at 33° C., and copperize for 3 hours;

[0038] (4) Purification: use supercritical carbon dioxide to purify and remove impurities for 2 hours at a pressure of 15MPa and a temperature of 36°C;

[0039] (5) Finished product: 0.01 part by weight of sodium hydroxide with a mass fraction of...

Embodiment 2

[0042] A method for producing sodium copper chlorophyllin by supercritical purification, comprising the following steps:

[0043] (1) Saponification: first add 4 to 12 parts of methanol solvent in 2 parts by weight of pasty chlorophyll to dissolve, wherein the mass fraction of chlorophyll in the pasty chlorophyll is 10%, and the water content is 20%; then add 0.6 ~1.6 parts of liquid caustic soda are kept saponified at 60°C for 1 hour;

[0044] (2) Washing: the saponified chlorophyll is extracted and washed 3 times with gasoline;

[0045] (3) Copperization: add copper chloride that is 0.2 parts by weight to the saponified chlorophyll after washing, insulate at 48° C., and copperize for 3 hours;

[0046] (4) Purification: use supercritical carbon dioxide to purify and remove impurities for 2 hours at a pressure of 27MPa and a temperature of 48°C;

[0047] (5) Finished product: 0.02 part by weight of sodium hydroxide with a mass fraction of 97.5% is added to the purified coppe...

Embodiment 3

[0050] A method for producing sodium copper chlorophyllin by supercritical purification, comprising the following steps:

[0051] (1) Saponification: first add 3.2 to 9.6 parts of acetone solvent in the pasty chlorophyll of 1.6 parts by weight to dissolve, wherein the mass fraction of chlorophyll in the pasty chlorophyll is 14.3%, and the water content is 23.7%; then add 0.48 ~1.28 parts of liquid caustic soda are incubated and saponified at 60°C for 1 hour;

[0052] (2) Washing: the saponified chlorophyll is extracted and washed 3 times with gasoline;

[0053](3) Copperization: add copper chloride that is 0.16 parts by weight to the saponified chlorophyll after washing, insulate at 37° C., and copperize for 3 hours;

[0054] (4) Purification: use supercritical carbon dioxide to purify and remove impurities for 2 hours at a pressure of 35MPa and a temperature of 65°C;

[0055] (5) Finished product: Add 0.016 parts by weight of sodium hydroxide with a mass fraction of 95.9% t...

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Abstract

The invention belongs to the technical field of sodium copper chlorophyllin production, and concretely relates to a method for producing sodium copper chlorophyllin through supercritical purification. The method for producing sodium copper chlorophyllin through supercritical purification comprises the following steps: 1, saponifying; 2, washing; 3, carrying out copper formation; 4, purifying obtained copper chlorophyllin by adopting supercritical carbon dioxide; and 5, preparing a finished product. The method adopts a supercritical technology to purify the copper chlorophyllin, so the particularity of the molecular structure of chlorophyll derivatives is overcome, the copper chlorophyllin yield is greatly improved, and the sodium copper chlorophyllin production process is efficient and environmentally-friendly.

Description

technical field [0001] The invention belongs to the technical field of sodium copper chlorophyllin production, and in particular relates to a method for producing sodium copper chlorophyllin through supercritical purification. Background technique [0002] Sodium copper chlorophyllin is a metal porphyrin with high stability. It is a dark green powder. It has been approved by relevant international health organizations for use in food. It is also an edible natural color approved by China. 2011 "Hygienic Standards for the Use of Food Additives", widely used as food additives, cosmetic additives, food colorants, pharmaceuticals and other fields. [0003] Chlorophyll, the raw material for the production of sodium copper chlorophyllin, is easily soluble in organic solvents such as ether and acetone and oils, slightly soluble in alcohol, but insoluble in water. Chlorophyll has certain particularity in molecular structure. Its molecular structure contains a porphine ring formed by...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D487/22
CPCC07D487/22Y02P20/54
Inventor 曹永民李涛
Owner SHANDONG GUANGTONGBAO PHARMA
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