Salinomycin granular preparation process

A technology of granule preparation and salinomycin, which is applied in the field of medicine, can solve the problems of low yield and achieve the effects of increasing yield, increasing the speed of layering, and shortening the time of layering

Inactive Publication Date: 2016-02-17
CHINA CHENGDU ANIMAL HUSBANDRY IND BIOPHARM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved by the present invention is to provide a salinomycin granule preparation process to overcome the low yield problem caused by the existing salinomycin granule preparation process

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] A salinomycin granule preparation process, comprising the following steps:

[0020] 1) Preparation of acidic fermentation broth: adjust the pH of the salinomycin fermentation broth with a drug price of 80,000u / ml to 4.0 with sulfuric acid;

[0021] 2) Pretreatment of the acidic fermentation broth: keep the pH-adjusted acidic fermentation broth at 60°C for 3 hours;

[0022] 3) Preparation of salinomycin feed liquid: adding a certain amount of calcium carbonate to the acidic fermentation liquid obtained in step 2) to make salinomycin feed liquid, the amount of calcium carbonate added is 10% of the mass of the acidic fermentation liquid;

[0023] 4) Spray drying: the salinomycin feed solution prepared in step 3) is spray-dried into granules to obtain salinomycin granules.

Embodiment 2

[0025] A salinomycin granule preparation process, comprising the following steps:

[0026] 1) Preparation of acidic fermentation broth: adjust the pH of the salinomycin fermentation broth with a drug price of 90000u / ml to 4.5 with sulfuric acid;

[0027] 2) Pretreatment of the acidic fermentation broth: keep the pH-adjusted acidic fermentation broth at 62°C for 3.5 hours;

[0028] 3) Preparation of salinomycin feed liquid: adding a certain amount of calcium carbonate to the acidic fermentation liquid obtained in step 2) to make salinomycin feed liquid, the amount of calcium carbonate added is 15% of the mass of the acidic fermentation liquid;

[0029] 4) Spray drying: the salinomycin feed solution prepared in step 3) is spray-dried into granules to obtain salinomycin granules.

Embodiment 3

[0031] A salinomycin granule preparation process, comprising the following steps:

[0032] 1) Preparation of acidic fermentation broth: adjust the pH of the salinomycin fermentation broth with a drug price of 100,000u / ml to 5.0 with sulfuric acid;

[0033] 2) Pretreatment of the acidic fermentation broth: keep the pH-adjusted acidic fermentation broth at 65°C for 4 hours;

[0034] 3) Preparation of salinomycin feed liquid: adding a certain amount of calcium carbonate to the acidic fermentation liquid obtained in step 2) to make salinomycin feed liquid, the amount of calcium carbonate added is 20% of the mass of the acidic fermentation liquid;

[0035] 4) Spray drying: the salinomycin feed solution prepared in step 3) is spray-dried into granules to obtain salinomycin granules.

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PUM

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Abstract

The invention relates to a salinomycin granular preparation process. The process comprises the steps that acid fermentation liquor is prepared, wherein the pH of salinomycin fermentation liquor is adjusted to be between 4.0 and 5.0 through the acid liquor; the acid fermentation liquor is pretreated, wherein the acid fermentation liquor with the adjusted pH is kept at the temperature between 60 DEG C and 65 DEG C for 3-4 hours; salinomycin feed liquor is prepared, wherein a certain amount of calcium carbonate is added to the obtained acid fermentation liquor to prepare the salinomycin feed liquor; spray drying is conducted, wherein the prepared salinomycin feed liquor is prepared into granules through a spray drying method, and then a salinomycin granular preparation is obtained. According to the process, acid fermentation is adopted for the salinomycin fermentation process, so that the fermentation liquor layering speed is increased, layering time is shortened, layering is thorough, and the yield of salinomycin is increased.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a salinomycin granule preparation process. Background technique [0002] Salinomycin is a polyether ionophore antibiotic produced by Streptomyces albus. Salinomycin granule preparation not only has good antibacterial effect, low toxicity and low residue, simple production process, readily available raw materials and low price, it is one of the most promising veterinary drugs recognized in the market. [0003] Salinomycin has a strong inhibitory and killing effect on most Gram-positive bacteria and various coccidiosis, and it is not easy to produce drug resistance and cross-resistance. It is excreted quickly and the residual amount is extremely low. It can be used to prevent diarrhea, Promote production and increase survival rate. Salinomycin has a cation transport function in cells, especially for potassium ions, sodium ions, and rubidium ions, but these ions selectively flow ...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K31/351A61P31/04
Inventor 廖成斌卢朝成
Owner CHINA CHENGDU ANIMAL HUSBANDRY IND BIOPHARM
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