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A magneto-optical dual-mode imaging nanoprobe and its application

A magneto-optical dual-mode, nano-probe technology, applied in the field of biomedicine, can solve the problem of not being able to provide information on the structure and function of biological tissues, achieve good blood circulation time in the body, good clinical transformation prospects, and easy surface functional modification Effect

Active Publication Date: 2019-08-02
SUZHOU INST OF NANO TECH & NANO BIONICS CHINESE ACEDEMY OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Moreover, these imaging methods can only provide preoperative tumor detection, but cannot provide real-time biological tissue structure and function information during the operation. The success of the operation depends largely on the subjective judgment of the surgeon, so there is a relatively large risk

Method used

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  • A magneto-optical dual-mode imaging nanoprobe and its application
  • A magneto-optical dual-mode imaging nanoprobe and its application
  • A magneto-optical dual-mode imaging nanoprobe and its application

Examples

Experimental program
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Effect test

Embodiment 1

[0031] NIR Ag 2 S quantum dots: The surface ligand is lipoic acid, with an average of about 5.4 nm. The preparation method is as follows: 0.1 mmol of silver diethyldithiocarbamate and 10 g of dodecanethiol are mixed in a flask and placed in a N 2 The temperature was raised to 200 °C in the atmosphere and kept for 1 h. Finally, after the solution was naturally cooled to room temperature, 50 mL of absolute ethanol was added, centrifuged, washed, dispersed in cyclohexane, and the same volume of absolute ethanol was added. Sonicated in a vacuum cleaner for 4 h, then centrifuged and washed with deionized water to obtain water-soluble Ag particles with a particle size of about 5 nm. 2 S quantum dots.

[0032] Preparation of a magneto-optical dual-mode nanoprobe: a near-infrared Ag 2 S quantum dots, Gd-DOTA, are assembled by amino-functionalized PEG molecules. Among them, Gd-DOTA was purchased from Sigma, and amino-functionalized modified PEG was purchased from Sunbio. Its prepa...

Embodiment 2

[0044] NIR Ag 2 Se quantum dots: The surface ligand is C18-PMH-PEG, with an average size of 3.5 nm. The preparation method is as follows: add 0.04 mmol Ag-Oleylamine, 7 mL toluene, 3 mL dodecanethiol, and 7 mL 0.01 mmol / L NaHSe solution into a 50 mL reactor and stir for 5 min, then place it at 180 °C for 1 h. Then use 60 mL absolute ethanol, centrifuge, wash, disperse in chloroform, and then add 50 mg DSPE-PEG-NH 2 (purchased from Nanocs) and stirred for 12 h, finally washed by centrifugation and dispersed in water.

[0045] Fabrication of magneto-optical dual-mode nanoprobes: from near-infrared Ag 2 Se quantum dots and Gd-DTAP were assembled by amino-functionalized PEG molecules. Among them, Gd-DTPA was purchased from Sigma, and amino-functionalized modified PEG was purchased from Sunbio.

[0046] Its preparation method is as follows.

[0047] (1) Chemically cross-linked Gd chelate molecules and modified PEG molecules: 50 mg Gd-DTAP, 100 mg DSPE-PEG-NH 2 , add 10 mL c...

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Abstract

The invention discloses a magneto-optical double-mode imaging nanoprobe and application thereof. The nanoprobe comprises a kernel, a magnetic material and synthetic polymers or biomacromolecules, wherein the kernel is formed by quanta; and the synthetic polymers or biomacromolecules are connected between the kernel and the magnetic material, are connected with the magnetic material through chemical crosslinking reaction, and are connected with the surface of the kernel through a chemical crosslinking process, a hydrophobic force or a Van der Waals' force. Through the magneto-optical difunctional probe, tumor in-situ, real-time and visual diagnosis and fluorescent guided excision can be realized.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to a nanoprobe with magneto-optical dual-mode imaging function and its application. Background technique [0002] Cancer is one of the major diseases that threaten human life and health. Due to the limitation of radiation dose and multi-drug resistance of tumors, it is difficult to completely eliminate tumor cells in the body through radiotherapy and chemotherapy. Surgery remains the treatment of choice for the vast majority of solid tumors. Nevertheless, a large number of clinicopathological results show that the occurrence of early tumors is relatively hidden and no obvious lesion area can be found, and the tumors show aggressive and infiltrating growth, resulting in blurred borders with normal tissues, and tumors are often accompanied by important blood vessels and nerves. etc., thereby bringing great difficulties to the safe and complete excision of the lesion tissue in the operatio...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/00A61K49/12A61K49/14
Inventor 王强斌李春炎张叶俊董博华
Owner SUZHOU INST OF NANO TECH & NANO BIONICS CHINESE ACEDEMY OF SCI