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Sterilizing-and-disinfecting-type coupling agent and preparing method thereof

A sterilizing and couplant technology, applied in the direction of echo/ultrasonic imaging agents, etc., can solve the problems of high safety, fast drying time, poor adhesion, etc., and achieve less sound attenuation and good tissue compatibility , enhance the effect of bactericidal and antibacterial properties

Inactive Publication Date: 2016-02-17
佛山市平创医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The object of the present invention is to provide a sterilizing and disinfecting coupling agent for the deficiencies of the prior art. The sterilization and disinfecting coupling agent is prepared from components with good water solubility and no corrosive effect on the ultrasonic probe, which is non-destructive to the ultrasonic probe and plays a role The function of protecting the probe; the coupling agent uses dichlorophenoxychlorophen as the bactericide and methyl p-hydroxybenzoate as the bacteriostatic agent, and the synergistic effect of the two can achieve safe and stable bactericidal and bacteriostatic in the formula; The couplant has good viscosity, good compatibility with the skin, and good wetting performance with human skin and ultrasonic probes, which can solve the problems of poor adhesion and too fast drying time of the existing couplant; the couplant The cytotoxicity is greatly reduced, and the use safety is high; the irritation to the skin is low, and the components with repair function in the formula can promote the repair of damaged skin at the same time

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033]Embodiment 1 adopts the following formula to prepare the sterilizing and disinfecting coupling agent of the present invention: each component and its mass ratio are as follows: Carbomer 9400.6%, propylene glycol 10%, glycerol 15%, vitamin B50.1%, polyethylene Pyrrolidone K301%, Dichlorophenoxychlorophene 0.2%, Methylparaben 0.2%, Triethanolamine 0.81%, Sodium Lauryl Sulfate 0.5%, Purified Water 71.59%.

[0034] With the above formula, adopt the following steps to produce 100Kg of sterilizing and disinfecting coupling agent products:

[0035] (1) Pour 64.0kg of purified water into the stainless steel drum, start the mixer, and stir the purified water at room temperature at a speed of 800-1000r / min;

[0036] (2) Weigh 600g of Carbomer 940, and slowly scatter it into the purified water being stirred in step (1) to avoid the aggregation of Carbomer, and keep stirring until no white Carbomer particles can be seen in the dispersion;

[0037] (3) At room temperature, adjust th...

Embodiment 2

[0044] Embodiment 2 adopts the following formula to prepare the sterilizing and disinfecting coupling agent of the present invention: each component and its mass ratio are as follows: Carbomer 9400.4%, propylene glycol 12%, glycerol 17%, vitamin B50.08%, polyethylene Pyrrolidone K300.8%, dichlorophenoxychlorophene 0.15%, methyl paraben 0.25%, triethanolamine 1%, sodium lauryl sulfate 0.55%, purified water balance.

[0045] The preparation method is as follows:

[0046] (1) Inject 88% of the amount of purified water into the stainless steel, start the mixer, and stir the purified water at room temperature at a speed of 1000r / min;

[0047] (2) Weigh Carbomer 940, and slowly scatter it into the purified water being stirred in step (1) to avoid agglomeration of Carbomer, and keep stirring until no white Carbomer particles can be seen in the dispersion;

[0048] (3) At room temperature, adjust the stirring speed to 300r / min, slowly add polyvinylpyrrolidone K30, and stir until the ...

Embodiment 3

[0054] Embodiment 3 adopts the following formula to prepare the sterilizing and disinfecting coupling agent of the present invention: each component and its mass ratio are as follows: Carbomer 9400.8%, propylene glycol 8%, glycerol 13%, vitamin B50.1%, polyethylene Pyrrolidone K300.7%, dichlorophenoxychlorophene 0.22%, methyl paraben 0.15%, triethanolamine 0.6%, sodium lauryl sulfate 0.5%, purified water balance.

[0055] The preparation method is as follows:

[0056] (1) Inject 85% of the amount of purified water into the stainless steel iron container, start the mixer, and stir the purified water at room temperature at a speed of 800r / min;

[0057] (2) Weigh Carbomer 940, and slowly scatter it into the purified water being stirred in step (1) to avoid agglomeration of Carbomer, and keep stirring until no white Carbomer particles can be seen in the dispersion;

[0058] (3) At room temperature, adjust the stirring speed to 300r / min, slowly add polyvinylpyrrolidone K30, and st...

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Abstract

The invention discloses a sterilizing-and-disinfecting-type coupling agent and a preparing method thereof. The sterilizing-and-disinfecting-type coupling agent is prepared from, by mass, carbomer 940, propylene glycol, glycerine, vitamins B5, polyvinylpyrrolidone K30, triclosan, methyl parahydroxybenzoats, triethanolamine, lauryl sodium sulfate and purified water. Compared with the prior art, the sterilizing-and-disinfecting-type coupling agent is good in stickiness and skin compatibility, and has good infiltrating performance for the skin and an ultrasonic probe, and the problems that an existing coupling agent is poor in stickiness and excessively short in drying time can be solved; due to the synergistic effect of the triclosan and the methyl parahydroxybenzoats in the formula, the coupling agent achieves safe and stable sterilization and bacteriostasis; the cytotoxicity of the coupling agent is greatly reduced, and use safety is high; the skin irritation of the coupling agent is low, and repairing of injured skin can be promoted at the same time through components with the repairing function in the formula. The preparing method of the coupling agent is simple, and industrial production can be easily achieved.

Description

technical field [0001] The invention relates to a coupling agent and a preparation method thereof, in particular to a sterilizing and disinfecting medical ultrasonic coupling agent and a preparation method thereof, belonging to the technical field of medical ultrasonic imaging agents. Background technique [0002] Ultrasound is a sound wave with a frequency above 20,000 Hz. Ultrasound can propagate in a certain direction and can penetrate objects. If it encounters obstacles, it will generate echoes. Different obstacles will produce different echoes. People pass through The instrument collects this echo and displays it on a screen, which can be used to understand the internal structure of the object. [0003] Using this principle, people use ultrasound to diagnose and treat human diseases. Ultrasound propagates in the human body. Due to the differences in the acoustic characteristics of various tissues of the human body, the ultrasonic wave produces reflection, refraction, s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/22
Inventor 叶剑生桂茂林
Owner 佛山市平创医疗科技有限公司
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