Preparation method of secondarily-crosslinked adsorption resin

A technology for secondary cross-linking and resin adsorption, applied in chemical instruments and methods, other chemical processes, etc. Poor tolerance, etc.

Active Publication Date: 2016-03-23
JAFRON BIOMEDICAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, when this method is used for post-crosslinking, the swelling effect of ethanol is limited, resulting in a very low degree of post-crosslinking reaction. The ability to remove exogenous or endogenous toxins in the blood is very low, and blood compatibility is poor

Method used

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  • Preparation method of secondarily-crosslinked adsorption resin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Step 1: The synthesis process of polystyrene resin white balls is as follows.

[0040] Add 500mL of an aqueous solution containing 1.5wt% gelatin into a 1000mL three-neck flask, stir and dissolve as the water phase.

[0041] Take a 500mL beaker, add 6.94g of divinylbenzene, 76.92g of styrene, 83.86g of toluene, 50.32g of 200# gasoline, and 0.5g of benzoyl peroxide into it, mix well to form an oil phase, and add it to a three-necked flask . Then the temperature was raised to 75°C under mechanical stirring, and the reaction was carried out for 7 hours, and then the temperature was raised to 85°C for 13 hours. After the reaction, the porogen was evaporated, washed with water until the washing solution was clear, then suction filtered, dried, and sieved, and the resin with a particle size of 0.4mm to 2mm was selected to obtain the desired polystyrene-divinylbenzene white ball ( A type of polystyrene resin white ball).

[0042] Step 2: The process of the chloromethylation...

Embodiment 2

[0048] Step 1: The synthesis process of polystyrene resin white balls is as follows.

[0049] Add 500mL of an aqueous solution containing 2.0wt% polyvinyl alcohol into a 1000mL three-neck flask, stir and dissolve it as the water phase.

[0050] Take a 500mL beaker, add 6.94g of divinylbenzene, 76.92g of styrene, 55g of toluene, 45g of 200# gasoline, and 1.0g of benzoyl peroxide into it, mix well to form an oil phase, and add it to a three-necked flask. Then the temperature was raised to 75°C under mechanical stirring, and the reaction was carried out for 7 hours, and then the temperature was raised to 85°C for 13 hours. After the reaction, the porogen was evaporated, washed with water until the washing solution was clear, then suction filtered, dried, and sieved, and the resin with a particle size of 0.4mm to 2mm was selected to obtain the desired polystyrene-divinylbenzene white ball ( polystyrene resin white balls).

[0051] Step 2: The process of the chloromethylation rea...

Embodiment 3

[0057] Step 1: The synthesis process of polystyrene resin white balls is as follows.

[0058] Add 500mL of an aqueous solution containing 2.0wt% polyvinyl alcohol into a 1000mL three-neck flask, stir and dissolve it as the water phase.

[0059] Take a 500mL beaker, add 18.52g of divinylbenzene, 74.08g of styrene, 87.97g of xylene, 69.45g of cyclohexane, and 0.5g of azobisisobutyronitrile into it. in the flask. Then the temperature was raised to 75°C under mechanical stirring, and the reaction was carried out for 5 hours, and then the temperature was raised to 85°C for 7 hours. After the reaction, the porogen was evaporated, washed with water until the washing solution was clear, then suction filtered, dried, and sieved, and the resin with a particle size of 0.4mm to 2mm was selected to obtain the desired polystyrene-divinylbenzene white ball ( polystyrene resin white balls).

[0060] Step 2: The process of the chloromethylation reaction is as follows.

[0061] First, add 3...

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Abstract

The invention relates to a preparation method of secondarily-crosslinked adsorption resin. The preparation method includes a secondary crosslinking step in which polystyrene resin chloromethylated bead is subjected to a secondary crosslinking reaction to obtain the secondarily-crosslinked adsorption resin. The secondary crosslinking step includes a still-standing and swelling process, in which 1 part by weight of the polystyrene resin chloromethylated bead, 0.5-4 parts by weight of an alcohol substance and 4-6 parts by weight of 1,2-dichloroethane are added to perform the still-standing and swelling process. The secondarily-crosslinked adsorption resin is used for blood purification. Through the preparation method, residual chloromethyl groups in ultrahigh-crosslinked polystyrene-divinylbenzene resin, thereby increasing chemical stability and blood compatability of the adsorption resin.

Description

technical field [0001] The invention relates to a preparation method of a secondary cross-linking adsorption resin used for blood purification, in particular to a preparation method of a secondary cross-linking adsorption resin which improves the secondary cross-linking step. Background technique [0002] Hemoperfusion is the use of power to lead the patient's blood to the extracorporeal circulation, and remove the endogenous or exogenous poisons or pathogenic substances in the patient's blood through the adsorbent with special adsorption function in the hemoperfusion device, so as to achieve blood purification. A healing technique. At present, hemoperfusion technology has been widely used in the fields of renal failure, severe liver disease, poisoning, infection and critical illness. [0003] The adsorbents in the hemoperfusion can be resin adsorbents, activated carbon adsorbents, carbonized resin adsorbents, natural polymer adsorbents and the like. The more commonly used...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/24C08F212/08C08F212/36C08F2/18C08F8/24C08J9/28B01J20/26B01J20/30
CPCB01J20/267B01J2220/4812C08F2/18C08F8/24C08F212/08C08J3/24C08J9/28C08J2201/0502C08F212/36
Inventor 董凡揭油平邵柯
Owner JAFRON BIOMEDICAL
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