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Metformin-acipimox compound sustained-release capsule and preparing method

A technology of metformin and acipolimus, applied in the field of medicine, can solve the problems of inconvenience in taking, high dosage of tableting auxiliary materials, and high packaging cost, and achieve the effects of convenient taking, reducing dosing frequency and low cost.

Inactive Publication Date: 2016-04-13
QINGDAO HAIZHIYUAN INTELLIGENT TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] With the improvement of living conditions of modern people, most diabetic patients are accompanied by hyperlipidemia. Since a single drug is often unable to achieve the desired curative effect, clinically, hypoglycemic drugs and blood lipid-lowering drugs are often used in combination to achieve better curative effect. However, it is inconvenient to take two or more single-prescription drugs in combination, and the amount of excipients for tablet compression is relatively large, and the packaging cost is high. Therefore, making two or more than two drugs into a compound preparation is not only convenient for medication, Moreover, it reduces the cost of auxiliary materials and packaging, which is conducive to reducing drug prices and industrial production

Method used

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  • Metformin-acipimox compound sustained-release capsule and preparing method
  • Metformin-acipimox compound sustained-release capsule and preparing method
  • Metformin-acipimox compound sustained-release capsule and preparing method

Examples

Experimental program
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Effect test

Embodiment 1

[0026] A compound sustained-release capsule of metformin and acipimox. The components and parts by weight of the sustained-release capsule include: 15 parts of metformin, 15 parts of acipimus, 3 parts of polyacrylic resin, 1 part of polyethylene, and 0.2 parts of glyceride 0.3 parts of hypromellose, 5 parts of microcrystalline cellulose, 3 parts of starch, and 1 part of talcum powder.

[0027] A preparation method of metformin acipimox compound sustained-release capsules, comprising the steps of:

[0028] 1) Prepare materials, prepare materials according to the components and parts by weight of a metformin-acipimox compound sustained-release capsule, wherein metformin is pulverized through a 120 mesh sieve, acipimox is pulverized through a 200 mesh sieve, microcrystalline cellulose , starch, and talcum powder were pulverized respectively through a 100-mesh sieve;

[0029] 2) The preparation of metformin-acipimox drug-containing pellets, metformin, acipimox, microcrystalline c...

Embodiment 2

[0034] A compound sustained-release capsule of metformin and acipimox, the components and parts by weight of the sustained-release capsule include: 20 parts of metformin, 20 parts of acipimus, 4 parts of polyacrylic resin, 2 parts of polyethylene, and 0.4 parts of glyceride 0.5 parts of hypromellose, 8 parts of microcrystalline cellulose, 5 parts of starch, and 3 parts of talcum powder.

[0035] A preparation method of metformin acipimox compound sustained-release capsules, comprising the steps of:

[0036] 1) Prepare materials, prepare materials according to the components and parts by weight of a metformin-acipimox compound sustained-release capsule, wherein metformin is pulverized through a 120 mesh sieve, acipimox is pulverized through a 200 mesh sieve, microcrystalline cellulose , starch, and talcum powder were pulverized respectively through a 100-mesh sieve;

[0037]2) The preparation of metformin-acipimox drug-containing pellets, metformin, acipimox, microcrystalline ...

Embodiment 3

[0042] A compound sustained-release capsule of metformin and acipimox. The components and parts by weight of the sustained-release capsule include: 17 parts of metformin, 17 parts of acipimus, 3.5 parts of polyacrylic resin, 1.5 parts of polyethylene, and 0.3 parts of glyceride 0.4 parts of hypromellose, 6 parts of microcrystalline cellulose, 4 parts of starch, and 2 parts of talcum powder.

[0043] A preparation method of metformin acipimox compound sustained-release capsules, comprising the steps of:

[0044] 1) Prepare materials, prepare materials according to the components and parts by weight of a metformin-acipimox compound sustained-release capsule, wherein metformin is pulverized through a 120 mesh sieve, acipimox is pulverized through a 200 mesh sieve, microcrystalline cellulose , starch, and talcum powder were pulverized respectively through a 100-mesh sieve;

[0045] 2) The preparation of metformin-acipimox medicated pellets, metformin, acipimox, microcrystalline c...

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Abstract

The invention discloses a metformin-acipimox compound sustained-release capsule and a preparing method. Components of the sustained-release capsule comprise melbine, acipimox, polyacrylic resin, polyethylene, glyceride, hydroxypropyl methylcellulose, microcrystalline cellulose, starch and talcum powder. The preparing method comprises preparing materials: stock for preparing metformin-acipimox containing pellets, preparing metformin-acipimox slow release pellets, and filling. The compound sustained-release capsule can treat high blood sugar, treat high blood fat and improve curative effect of the medicine, is high in medicine effect ratio and convenient to take, and realizes in vivo durable and slow release of the medicine, thus reducing a administration frequency. By controlling concentration of the effective components in blood, a medicine effect is maintained, the number of medicine release peak time is reduced, and certain protection for organs of a patient is realized. The whole preparing process is high in stability, fast in speed, extremely less in pellet crushing and dust, environmentally friendly and good in stability.

Description

technical field [0001] The invention belongs to the technical field of medicine, and specifically relates to a compound sustained-release capsule of metformin and acipimox and a preparation method thereof. Background technique [0002] Metformin, English name: Metformin, Chinese aliases: Metformin, Metformin Hydrochloride, Metformin, Metformin Hydrochloride, Metformin, Hypoglycemic, Rickose, Medicom. Main purposes: 1) For type Ⅱ diabetes mellitus, especially obese type Ⅱ diabetes mellitus, which is ineffective for simple diet control and physical exercise. 2) Combining this product with insulin can reduce the dosage of insulin and prevent hypoglycemia. 3) It can be used in combination with xanthyl urea drugs for blood sugar, which has a synergistic effect. Mechanism of action: ① Promote the utilization of glucose by surrounding tissue cells (muscle, etc.); ② Inhibit hepatic gluconeogenesis, thereby reducing the output of glycogen; ③ Inhibit the uptake of glucose by intesti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4965A61K9/52A61P3/10A61P3/06A61K31/155
CPCA61K31/4965A61K9/0002A61K9/5047A61K31/155A61K2300/00
Inventor 王芬黄清华赵田孙强
Owner QINGDAO HAIZHIYUAN INTELLIGENT TECH
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