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Metformin-acipimox compound slow-release tablets and preparation method thereof

A technology for compound sustained-release tablets and metformin, which is applied in the field of medicine, can solve the problems of inconvenience in taking, high dosage of tableting excipients, and high packaging cost, and achieves the effects of convenient taking, reduced dosing frequency and low cost.

Inactive Publication Date: 2016-03-30
QINGDAO HAIZHIYUAN INTELLIGENT TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] With the improvement of living conditions of modern people, most diabetic patients are accompanied by hyperlipidemia. Since a single drug is often unable to achieve the desired curative effect, clinically, hypoglycemic drugs and blood lipid-lowering drugs are often used in combination to achieve better curative effect. However, it is inconvenient to take two or more single-prescription drugs in combination, and the amount of excipients for tablet compression is relatively large, and the packaging cost is high. Therefore, making two or more than two drugs into a compound preparation is not only convenient for medication, Moreover, it reduces the cost of auxiliary materials and packaging, which is conducive to reducing drug prices and industrial production

Method used

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  • Metformin-acipimox compound slow-release tablets and preparation method thereof
  • Metformin-acipimox compound slow-release tablets and preparation method thereof
  • Metformin-acipimox compound slow-release tablets and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0025] A compound sustained-release tablet of metformin and acipimox, the components and parts by weight of the sustained-release tablet include: 15 parts of metformin, 15 parts of acipimus, 5 parts of sodium alginate, 5 parts of povidone, microcrystalline 10 parts of cellulose, 0.5 parts of talc, 0.2 parts of sucrose ester, and 0.3 parts of polyoxyethylene-polyoxypropylene copolymer.

[0026] A preparation method of metformin acipimox compound sustained-release tablet, comprising the steps of:

[0027] 1) Prepare materials, prepare materials according to the components and parts by weight of a metformin-acipimox compound sustained-release tablet, wherein metformin is pulverized through a 120 mesh sieve, acipimox is pulverized through a 200 mesh sieve, sodium alginate, Povidone, microcrystalline cellulose, talcum powder, sucrose ester, polyoxyethylene-polyoxypropylene copolymer are pulverized respectively through an 80-mesh sieve;

[0028] 2) Granulating, mixing the materials...

Embodiment 2

[0033] A compound sustained-release tablet of metformin and acipimox, the components and parts by weight of the sustained-release tablet include: 20 parts of metformin, 20 parts of acipimus, 8 parts of sodium alginate, 10 parts of povidone, microcrystalline 15 parts of cellulose, 1 part of talc, 0.5 part of sucrose ester, 0.5 part of polyoxyethylene-polyoxypropylene copolymer.

[0034] A preparation method of metformin acipimox compound sustained-release tablet, comprising the steps of:

[0035] 1) Prepare materials, prepare materials according to the components and parts by weight of a metformin-acipimox compound sustained-release tablet, wherein metformin is pulverized through a 120 mesh sieve, acipimox is pulverized through a 200 mesh sieve, sodium alginate, Povidone, microcrystalline cellulose, talcum powder, sucrose ester, polyoxyethylene-polyoxypropylene copolymer are pulverized respectively through an 80-mesh sieve;

[0036] 2) Granulating, mixing the materials prepare...

Embodiment 3

[0041] A compound sustained-release tablet of metformin and acipimox, the components and parts by weight of the sustained-release tablet include: 18 parts of metformin, 18 parts of acipimus, 7 parts of sodium alginate, 8 parts of povidone, microcrystalline 14 parts of cellulose, 0.8 part of talc, 0.3 part of sucrose ester, 0.4 part of polyoxyethylene-polyoxypropylene copolymer.

[0042] A preparation method of metformin acipimox compound sustained-release tablet, comprising the steps of:

[0043] 1) Prepare materials, prepare materials according to the components and parts by weight of a metformin-acipimox compound sustained-release tablet, wherein metformin is pulverized through a 120 mesh sieve, acipimox is pulverized through a 200 mesh sieve, sodium alginate, Povidone, microcrystalline cellulose, talcum powder, sucrose ester, polyoxyethylene-polyoxypropylene copolymer are pulverized respectively through an 80-mesh sieve;

[0044]2) Granulating, mixing the materials prepare...

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Abstract

The present invention discloses metformin-acipimox compound slow-release tablets and a preparation method thereof, wherein the metformin-acipimox compound slow-release tablets comprise, by weight, 15-20 parts of metformin, 15-20 parts of acipimox, 5-8 parts of sodium alginate, 5-10 parts of povidone, 10-15 parts of microcrystalline cellulose, 0.5-1 part of talc powder, 0.2-0.5 part of sucrose ester, and 0.3-0.5 part of a polyoxyethylene-polyoxypropylene copolymer. The preparation method comprises: material preparation, granulating, pelletizing, and tableting. According to the present invention, the compound slow-release tablets can treat hyperglycemia and hyperlipemia, and has characteristics of medication effect improving, high effective drug proportion, easy taking, lasting and slow drug release in body, stable therapeutic drug level, and small fluctuation so as to reduce the administration frequency; and the concentration of the effective drug component in the blood is controlled to maintain the efficacy, such that the drug release peaking times can be reduced, and a certain protection is provided for organs of patients.

Description

technical field [0001] The invention belongs to the technical field of medicine, and specifically relates to a compound sustained-release tablet of metformin and acipimox and a preparation method thereof. Background technique [0002] Metformin, English name: Metformin, Chinese aliases: Metformin, Metformin Hydrochloride, Metformin, Metformin Hydrochloride, Metformin, Hypoglycemic, Rickose, Medicom. Main purposes: 1) For type Ⅱ diabetes mellitus, especially obese type Ⅱ diabetes mellitus, which is ineffective for simple diet control and physical exercise. 2) Combining this product with insulin can reduce the dosage of insulin and prevent hypoglycemia. 3) It can be used in combination with xanthyl urea drugs for blood sugar, which has a synergistic effect. Mechanism of action: ① Promote the utilization of glucose by surrounding tissue cells (muscle, etc.); ② Inhibit hepatic gluconeogenesis, thereby reducing the output of glycogen; ③ Inhibit the uptake of glucose by intestin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/22A61K31/4965A61P3/10A61P3/06A61K31/155
CPCA61K31/4965A61K9/0002A61K9/2054A61K31/155
Inventor 王芬黄清华赵田孙强
Owner QINGDAO HAIZHIYUAN INTELLIGENT TECH
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