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Hypertension-type obese gene individualization intervention composition and preparation method and system

A technology of obesity genes and compositions, applied in biochemical equipment and methods, bioreactor/fermenter combination, biochemical instruments, etc., can solve the problems of limited theoretical basis, lack of practical applicable execution technology, etc., and achieve easy operation Effect

Inactive Publication Date: 2016-04-13
上海中优精准医疗科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0034] However, the existing technology is still limited by the theoretical basis, and lacks the technology that can be applied in practice. The present invention uses genetic testing combined with dietary intervention to regulate nutrient intake, so as to achieve the goal of truly providing individualized intervention weight loss

Method used

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  • Hypertension-type obese gene individualization intervention composition and preparation method and system
  • Hypertension-type obese gene individualization intervention composition and preparation method and system
  • Hypertension-type obese gene individualization intervention composition and preparation method and system

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0112] The collection of embodiment 1 individual sample DNA

[0113] The DNA sample collection that present embodiment adopts is saliva sample, and specific implementation method is:

[0114] ① Tear off the outer packaging of the sampling swab, and take out the sampling swab.

[0115] ②The sampling swab was scraped up and down the left cheek in the mouth for more than 40 times.

[0116] ③Push the push rod of the sampling swab, and send the sampling swab head with the oral epithelial cells scraped into the sampling tube.

[0117] ④Repeat the above operation, take a sample from the right cheek of the mouth, and send the cotton head into another sampling tube.

[0118] The sample DNA taken is collected and numbered, and the next step of genetic testing is carried out after the sample file is established.

Embodiment 2

[0119] Example 2 Establishment of Joint Genotype Risk Level 1

[0120] The polymorphic sites detected in this example are: rs5051 (AGT), rs5186 (AGTR1) and rs1799983 (NOS3), which are marked as a, b, and c respectively, and their subtype risks are shown in Table 8 below :

[0121] Table 8

[0122] genetic polymorphism site

[0123] The risk grades calculated according to the single gene risk listed in Table 8 are shown in Table 4 above.

Embodiment 3

[0124] Example 3 Establishment of Joint Genotype Risk Level II

[0125] The polymorphic sites detected in this example are: rs5051 (AGT), rs5186 (AGTR1), rs1799983 (NOS3) and rs5443 (GNB3), which are respectively marked as a, b, c, d, and their subtypes The degree of risk is shown in Table 9 below:

[0126] Table 9

[0127] genetic polymorphism site

genotype

Risk (OR)

a

1(AA)

0.56

2(AG)

0.56

3(GG)

3.78

b

1(AA)

0.37

13 -->

2(AC)

2.71

3(CC)

2.71

c

1(GG)

0.21

2(GT)

4.21

3(TT)

4.21

d

1(CC)

0.45

2(CT)

2.2

3(TT)

2.2

[0128] The risk level calculated based on the single gene risk listed in the above table is shown in Table 10 below:

[0129] Table 10

[0130]

[0131]

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Abstract

The invention discloses a hypertension-type obese gene individualization intervention composition and a preparation method and system. The preparation method comprises six steps: obtaining a sample DNA; establishing combined genotype risk grades; detecting an individual gene to obtain a corresponding gene type; determining a formula of the composition according to the risk grade to which a detection result belongs; making the corresponding composition according to the formula; using the composition on a sample, thus obtaining a weight reduction effect. The targeted weight reduction composition can be prepared according to the combined genotype of an obese individual, and the weight reduction effect is better; the combined genotype of the individual is obtained through one-time detection procedures by adopting a combined detection technology; an individualization intervention composition system is adopted, and an integrated process from obtaining the sample DNA to achieving the weight reduction effect of the sample is realized; the individualization intervention composition prepared by the preparation method and system has a good effect.

Description

technical field [0001] The present invention relates to an obesity gene individualized intervention composition, in particular to a preparation method and system of a hypertensive obesity gene individualized intervention composition. Background technique [0002] Obesity, as a disease, is seriously threatening human health. The World Health Organization Expert Committee proposes to use Body-Mass Index (BMI) as the standard for overweight or obesity, that is, a BMI between 25 and 28 is considered overweight, 28 to 32 is considered obese, and a BMI greater than 32 is considered very obese. Obesity is a chronic disease closely related to genetic factors and lifestyle. It can cause elevated blood lipids, which can easily lead to fatty liver, arterial vascular disease, heart disease, and diabetes. Obese children can also cause sexual dysfunction and lead to The morbidity and mortality of various diseases increase in adulthood. [0003] The current clinical treatment methods for...

Claims

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Application Information

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IPC IPC(8): C12Q1/68C12M1/34A23L33/00
CPCC12Q1/6883A23V2002/00C12Q2600/156
Inventor 卞雪莲毛丹丹王校傅咏南邹创龚丽何骏奇张奕
Owner 上海中优精准医疗科技股份有限公司
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