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Instant pidotimod and preparation technology thereof

A pidotimod and instant technology, which is applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, and pill delivery, etc. It can solve problems such as slow dissolution speed and poor dispersion of ingredients

Inactive Publication Date: 2016-04-20
夏放军
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The pidotimod currently on the market has a slow dissolution rate and poor component dispersion effect

Method used

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  • Instant pidotimod and preparation technology thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] An instant pidotimod, comprising the following raw materials in parts by weight: 8 parts of anhydrous citric acid, 2 parts of stevioside, 1 part of cross-linked polyvinylpyrrolidone, 2 parts of sodium bicarbonate, sodium carboxymethyl starch 3 parts, 6 parts of potato starch, 18 parts of L-pyroglutamic acid, 15 parts of L-4-thiazolidine formate, 8 parts of ethyl acetate, 12 parts of acetic acid, 6 parts of dicyclohexylcarbodiimide, L - 2 parts of arginine, 1 part of tetramisole, 4 parts of konjac glucomannan and 1 part of gelatin.

[0021] A kind of preparation technology of instant pidotimod comprises the following steps:

[0022] 1) Pour 18-20 parts of L-pyroglutamic acid, 15-17 parts of L-4-thiazolidine carboxylate and 8-10 parts of ethyl acetate into the reaction kettle, and then add dicyclohexyl carbon di 6-8 parts of the imine undergo dehydration condensation reaction, fully react to form a precipitate, remove the precipitate by filtration, and prepare a solution...

Embodiment 2

[0031] An instant pidotimod, comprising the following raw materials in parts by weight: 4 parts of anhydrous citric acid, 4 parts of stevioside, 3 parts of cross-linked polyvinylpyrrolidone, 4 parts of sodium bicarbonate, sodium carboxymethyl starch 5 parts, 8 parts of potato starch, 20 parts of L-pyroglutamic acid, 17 parts of L-4-thiazolidine carboxylate, 10 parts of ethyl acetate, 14 parts of acetic acid, 8 parts of dicyclohexylcarbodiimide, L - 4 parts of arginine, 3 parts of tetramisole, 6 parts of konjac glucomannan and 3 parts of gelatin.

[0032] A preparation process for instant pidotimod, comprising the following steps:

[0033] 1) Pour 18-20 parts of L-pyroglutamic acid, 15-17 parts of L-4-thiazolidine carboxylate and 8-10 parts of ethyl acetate into the reaction kettle, and then add dicyclohexyl carbon di 6-8 parts of the imine undergo dehydration condensation reaction, fully react to form a precipitate, remove the precipitate by filtration, and prepare a solution...

Embodiment 3

[0042] An instant pidotimod, comprising the following raw materials in parts by weight: 6 parts of anhydrous citric acid, 3 parts of stevioside, 2 parts of cross-linked polyvinylpyrrolidone, 3 parts of sodium bicarbonate, sodium carboxymethyl starch 4 parts, 7 parts of potato starch, 19 parts of L-pyroglutamic acid, 16 parts of L-4-thiazolidine formate, 9 parts of ethyl acetate, 13 parts of acetic acid, 7 parts of dicyclohexylcarbodiimide, L - 3 parts of arginine, 2 parts of tetramisole, 5 parts of konjac glucomannan and 2 parts of gelatin.

[0043] A preparation process for instant pidotimod, comprising the following steps:

[0044] 1) Pour 18-20 parts of L-pyroglutamic acid, 15-17 parts of L-4-thiazolidine carboxylate and 8-10 parts of ethyl acetate into the reaction kettle, and then add dicyclohexyl carbon di 6-8 parts of the imine undergo dehydration condensation reaction, fully react to form a precipitate, remove the precipitate by filtration, and prepare a solution for la...

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Abstract

The invention discloses instant pidotimod comprising raw materials in parts by weight as follows: 4-8 parts of anhydrous citric acid, 2-4 parts of stevioside, 1-3 parts of crosslinked polyvinylpyrrolidone, 2-4 parts of sodium bicarbonate, 3-5 parts of sodium carboxymethyl starch, 6-8 parts of potato starch, 18-20 parts of L-pyroglutamic acid, 15-17 parts of L-4-thiazolidine formate, 8-10 parts of ethyl acetate, 12-14 parts of acetic acid, 6-8 parts of dicyclohexyl carbodiimide, 2-4 parts of L-arginine, 1-3 parts of tetramisol, 4-6 parts of glucomannan and 1-3 parts of gelatin. The instant pidotimod is very high in component dispersion and dissolution speed.

Description

technical field [0001] The invention relates to an instant pidotimod and a preparation process thereof. Background technique [0002] Pidotimod, developed by the Italian company Poliindustriachimica S.P.A in the 1980s, was approved for clinical use in 1993. It is a synthetic immune booster with a structure similar to that of a dipeptide. Its chemical name is (4R)-3-[[(2S)-5-oxo-2-pyrrolidinyl]carbonyl]-4-thiazolidinecarboxylic acid; has anti-toxicity, anti-irritation, anti-infection, anti-oxidation, anti- It can not only promote non-specific immune response, but also promote specific immune response; it is mainly used for the prevention and treatment of children's recurrent respiratory tract infection, urinary system infection, allergic rhinitis and asthma, and the treatment and prevention of acute exacerbation of chronic bronchitis, For upper respiratory tract infection, it can also be used for a variety of viral infections, malignant tumors and other chronic diseases to c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/36A61K47/32A61K47/02A61K47/12A61K9/20A61K31/427A61P37/04A61P11/00A61P13/00A61P37/08A61P11/02A61P11/06A61P31/12A61P35/00
CPCA61K9/2059A61K9/2009A61K9/2013A61K9/2027A61K9/205A61K31/427
Inventor 夏放军
Owner 夏放军