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Hollow calcium carbonate microsphere preparation method

A technology of hollow spheres and calcium carbonate, applied in the direction of calcium carbonate/strontium/barium, etc., to achieve the effect of high application potential, large specific surface area, and simple process

Inactive Publication Date: 2016-04-20
TIANJIN POLYTECHNIC UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, although these methods have been widely used, there are few studies on the synthesis of calcium carbonate utilizing polymer-surfactant composite structures in water (B.Chengetal, Mater.Lett.2004, 58, 1565- 1570.)

Method used

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  • Hollow calcium carbonate microsphere preparation method
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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] ①Take 10.0 g of polyvinylpyrrolidone (PVP), add 30 ml of distilled water, place it in an environment of 30 ° C, and stir it electromagnetically for 10 min to obtain a clear and transparent liquid A.

[0022] ②Weigh 11.1g calcium chloride (CaCl 2 ), dissolved in 50ml of distilled water, placed in an environment of 30°C, and electromagnetically stirred for 10 minutes to obtain a clear and transparent liquid B.

[0023] ③Weigh 13.8g potassium carbonate (Ka 2 CO 3 ), dissolved in 50ml of distilled water, placed in an environment of 30°C, and electromagnetically stirred for 10min. A clear and transparent liquid C was obtained.

[0024] ④ Measure 5ml of A and mix with 10ml of B and C solutions to obtain transparent and clear liquids D and E, and place D and E liquids at 30°C for 5 minutes with electromagnetic stirring.

[0025] ⑤ Slowly add liquid D dropwise (1d / s) into liquid E, and place the mixed liquid F at 30°C, and stir it electromagnetically for 30 minutes.

[002...

Embodiment 2

[0029] ①Take 10.0 g of polyvinylpyrrolidone (PVP), add 30 ml of distilled water, place it in an environment of 30 ° C, and stir it electromagnetically for 10 min to obtain a clear and transparent liquid A.

[0030] ②Weigh 11.1g calcium chloride (CaCl 2 ), dissolved in 50ml of distilled water, placed in an environment of 30°C, and electromagnetically stirred for 10 minutes to obtain a clear and transparent liquid B.

[0031] ③Weigh 13.8g potassium carbonate (Ka 2 CO 3 ), dissolved in 50ml of distilled water, placed in an environment of 30°C, and electromagnetically stirred for 10min. A clear and transparent liquid C was obtained.

[0032] ④ Measure 5ml of A and mix with 10ml of B and C solutions to obtain transparent and clear liquids D and E, and place D and E liquids at 30°C for 5 minutes with electromagnetic stirring.

[0033] ⑤ Slowly add liquid D dropwise (1d / s) into liquid E, and place the mixed liquid F at 30°C, and stir it electromagnetically for 45 minutes.

[003...

Embodiment 3

[0037] ①Take 10.0 g of polyvinylpyrrolidone (PVP), add 30 ml of distilled water, place it in an environment of 30 ° C, and stir it electromagnetically for 10 min to obtain a clear and transparent liquid A.

[0038] ②Weigh 11.1g calcium chloride (CaCl 2 ), dissolved in 50ml of distilled water, placed in an environment of 30°C, and electromagnetically stirred for 10 minutes to obtain a clear and transparent liquid B.

[0039] ③Weigh 13.8g potassium carbonate (Ka 2 CO 3 ), dissolved in 50ml of distilled water, placed in an environment of 30°C, and electromagnetically stirred for 10min. A clear and transparent liquid C was obtained.

[0040] ④ Measure 5ml of A and mix with 10ml of B and C solutions to obtain transparent and clear liquids D and E, and place D and E liquids at 30°C for 5 minutes with electromagnetic stirring.

[0041] ⑤ Slowly add liquid D dropwise (1d / s) into liquid E, and place the mixed liquid F at 30°C, and stir it electromagnetically for 45 minutes.

[004...

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Abstract

The invention relates to a hollow calcium carbonate microsphere preparation method, wherein a chemical precipitation method is used to obtain the hollow calcium carbonate microspheres with an inner diameter of about 3 [mu]m and a wall thickness of about 200 nm, 800 nm and 1000 nm at different aging times. According to the present invention, the obtained hollow calcium carbonate microspheres have characteristics of relative large specific surface area, large particle size adjustment range, large outer shell thickness adjustment range, and hollow sphere size adjustment range broadening; and the method has characteristics of simple process, safe operation, low cost and good repeatability, and can provide high potential application value as the drug carrier in the field of medicine after the suitable scale production.

Description

technical field [0001] The invention belongs to the preparation of calcium carbonate and relates to a preparation method of hollow calcium carbonate microspheres. This method uses a simple and effective chemical precipitation method to obtain micron-sized calcium carbonate hollow spheres with uniform shape and size on the basis of precise control of experimental conditions and parameters. This material is expected to be further applied to the targeted delivery of drugs to treat diseases. Background technique [0002] With the development of technology, it is found that when the size of the material reaches the nanometer scale, due to the small density of the micron or nanometer-sized hollow sphere, the large specific surface, and the generally nanostructure of the sphere wall, it often shows many differences from the bulk material. The physical and chemical properties of solid particles, such as optical, electrical, and magnetic properties, have potential applications in man...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01F11/18
Inventor 储德清王澳轩孙洪明王立敏马忠超
Owner TIANJIN POLYTECHNIC UNIV