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Amino/carboxyl composite self-assembly monomolecular film surface, preparation method thereof and application thereof

A self-assembly, molecular film technology, applied in the direction of metal material coating process, etc., to avoid acid-base reaction and improve the preparation method.

Active Publication Date: 2016-04-20
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, different proportions - NH 2 The impact of the charge on the surface of / -COOH composite SAMs on protein adsorption and cell behavior has not been reported

Method used

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  • Amino/carboxyl composite self-assembly monomolecular film surface, preparation method thereof and application thereof
  • Amino/carboxyl composite self-assembly monomolecular film surface, preparation method thereof and application thereof
  • Amino/carboxyl composite self-assembly monomolecular film surface, preparation method thereof and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] "Piranha" solution (H 2 O 2 :H 2 SO 4 =3:7(v / v)) Soak the gold substrate (gold flakes) for 15min. During the soaking process, the cleaning solution completely covers the gold flakes. At the beginning, a large number of bubbles are generated on the surface of the gold until no more bubbles are generated. After alternately washing with pure water for three times, dry it with nitrogen to obtain a clean gold substrate; immediately immerse the clean gold substrate in a concentration of 10 -3 molL -1 mercapto-undecylamine hydrochloride (-NH 2 ) in the ethanol solution of thiol for 12 h; after the reaction was completed, the modified gold substrate was washed with anhydrous ethanol for three times, dried with nitrogen and air-sealed for use, to obtain a self-assembled monomolecular membrane surface chemically modified by amino groups (ie- NH 2 chemically modified SAMs).

Embodiment 2

[0033] Load -NH in Example 1 2 The gold substrates of chemically modified SAMs were immersed in a concentration of 1 molL -1 bromoacetic acid (BrCH 2 COOH) and the concentration is 2molL -1 Acidification was carried out in the mixed solution of sodium hydroxide (NaOH), and the reaction time was controlled to 0.5h; the sample was taken out, washed and soaked in ultrapure water for 12h, the salt was absorbed, dried with nitrogen and air-sealed for later use, and the amino / carboxyl group composite self was obtained. Assemble molecular membrane surfaces.

Embodiment 3

[0035] Load -NH in Example 1 2 The gold substrates of chemically modified SAMs were immersed in a concentration of 1 molL -1 bromoacetic acid (BrCH 2 COOH) and the concentration is 2molL -1 Acidification treatment was carried out in the mixed solution of sodium hydroxide (NaOH), and the reaction time was controlled for 2h; the sample was taken out, washed and soaked in ultrapure water for 12h, the salt was absorbed, dried with nitrogen and air-sealed for use, and the amino / carboxyl group composite self-assembly was obtained. molecular membrane surface.

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Abstract

The invention belongs to the technical field of molecule self-assembly, and discloses an amino / carboxyl composite self-assembly monomolecular film surface, a preparation method thereof and an application thereof. The method comprises the following steps: a, pre-treating a substrate to obtain the substrate with a clean surface; b, soaking the substrate in the step a into a solution of an organic compound containing -NH2, reacting, washing and blow-drying to obtain a self-assembly molecular film chemically modified by amino; and c, soaking the substrate which is loaded with the self-assembly molecular film chemically modified by amino in the step b into a mixed solution of haloalkane acid and a catalyst to carry out acidifying treatment, taking out the substrate, cleaning and soaking, absorbing salts, blow-drying to obtain the amino / carboxyl composite self-assembly molecular film surface. According to the method, two organic reagents containing amino and carboxyl are not required to co-adsorb, so that acid-base reaction in the solution is avoided; and the prepared amino / carboxyl composite SAMs surface has different charge properties, and has remarkable influence on proteins sensitive to charges.

Description

technical field [0001] The invention belongs to the technical field of molecular self-assembly, and relates to an amino / carboxyl group composite self-assembled monomolecular membrane surface and a preparation method and application thereof. Background technique [0002] Self-assembled monolayers (SAMs) are two-dimensional monolayers in which surfactants are chemically adsorbed on substrates and spontaneously form oriented and ordered arrangements. Because the surface structure of SAMs is clear, and the terminal groups make the substrate surface have specific physical and chemical properties, the chemical properties are controllable, and it is often used as an ideal model for simulating specific surface chemical composition or structure. In biotechnology research, SAMs are ideal models for studying the interaction between substrate surfaces and biomolecules, and SAMs with complex functional groups have further expanded their scope of application by defining gradients of surfa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C23C22/02
CPCC23C22/02
Inventor 王迎军杜昶郝丽静赵娜如
Owner SOUTH CHINA UNIV OF TECH
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