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A kind of amino/carboxyl complex self-assembled monomolecular film surface and its preparation method and application

A technology of self-assembly and molecular film, which is applied in the coating process of metal materials, etc., to avoid acid-base reaction and improve the effect of preparation method

Active Publication Date: 2018-06-19
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, different proportions - NH 2 The impact of the charge on the surface of / -COOH composite SAMs on protein adsorption and cell behavior has not been reported

Method used

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  • A kind of amino/carboxyl complex self-assembled monomolecular film surface and its preparation method and application
  • A kind of amino/carboxyl complex self-assembled monomolecular film surface and its preparation method and application
  • A kind of amino/carboxyl complex self-assembled monomolecular film surface and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Using the "piranha" solution (H 2 o 2 :H 2 SO 4 =3:7(v / v)) Soak the gold substrate (gold flake) for 15min, the cleaning solution has completely submerged the gold flake during the immersion process, a large number of bubbles are generated on the gold surface at the beginning until no more bubbles are generated; use absolute ethanol and super After washing with pure water three times alternately, blow dry with nitrogen gas to obtain a gold substrate with a clean surface; immediately immerse the clean gold substrate in a concentration of 10 -3 mol L -1 Mercapto-undecylamine hydrochloride (-NH 2 ) thiol ethanol solution for 12h; after the reaction was completed, the modified gold substrate was washed three times with absolute ethanol, then dried with nitrogen and air-sealed for later use, to obtain the surface of the self-assembled monomolecular film chemically modified by amino groups (ie- NH 2 chemically modified SAMs).

Embodiment 2

[0033] Load-NH in embodiment 1 2 The gold substrates of chemically modified SAMs were soaked in a concentration of 1mol L -1 Bromoacetic acid (BrCH 2 COOH) and a concentration of 2mol L -1 acidification treatment in a mixed solution of sodium hydroxide (NaOH), and control the reaction time for 0.5h; take out the sample, wash and soak it in ultrapure water for 12h, absorb the salt, dry it with nitrogen and seal it for later use, and obtain the amino / carboxyl compound self- Assemble the molecular membrane surface.

Embodiment 3

[0035] Load-NH in embodiment 1 2 The gold substrates of chemically modified SAMs were soaked in a concentration of 1mol L -1 Bromoacetic acid (BrCH 2 COOH) and a concentration of 2mol L -1 Acidification treatment was carried out in a mixed solution of sodium hydroxide (NaOH), and the reaction time was controlled for 2 hours; the sample was taken out, washed and soaked in ultrapure water for 12 hours, the salt was absorbed, and dried by nitrogen gas and sealed for later use to obtain the amino / carboxyl compound self-assembled Molecular membrane surface.

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Abstract

The invention belongs to the technical field of molecule self-assembly, and discloses an amino / carboxyl composite self-assembly monomolecular film surface, a preparation method thereof and an application thereof. The method comprises the following steps: a, pre-treating a substrate to obtain the substrate with a clean surface; b, soaking the substrate in the step a into a solution of an organic compound containing -NH2, reacting, washing and blow-drying to obtain a self-assembly molecular film chemically modified by amino; and c, soaking the substrate which is loaded with the self-assembly molecular film chemically modified by amino in the step b into a mixed solution of haloalkane acid and a catalyst to carry out acidifying treatment, taking out the substrate, cleaning and soaking, absorbing salts, blow-drying to obtain the amino / carboxyl composite self-assembly molecular film surface. According to the method, two organic reagents containing amino and carboxyl are not required to co-adsorb, so that acid-base reaction in the solution is avoided; and the prepared amino / carboxyl composite SAMs surface has different charge properties, and has remarkable influence on proteins sensitive to charges.

Description

technical field [0001] The invention belongs to the technical field of molecular self-assembly, and relates to an amino / carboxyl compound self-assembled monomolecular film surface and its preparation method and application. Background technique [0002] Self-assembled monomolecular membranes (SAMs) are two-dimensional monomolecular membranes that are chemisorbed by surfactants on a substrate and spontaneously form an ordered arrangement of orientations. Because the surface structure of SAMs is clear, the terminal groups make the substrate surface have specific physical and chemical properties, so the chemical properties are controllable, and they are often used as an ideal model for simulating specific surface chemical composition or structure. In terms of biotechnology research, SAMs are ideal models for studying the interaction between substrate surfaces and biomolecules, and SAMs with complex functional groups further expand its application range by defining the gradient ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C23C22/02
CPCC23C22/02
Inventor 王迎军杜昶郝丽静赵娜如
Owner SOUTH CHINA UNIV OF TECH
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