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Oral micro-effervescent granules and preparation method thereof

A technology of microbubbles and granules, applied in the field of oral micro-effervescent granules and their preparation, can solve the problems of affecting the absorption of functional substances, poor disintegration effect, and inability to fill the oral cavity, and achieves favorable absorption, wide disintegration range, and taste Good results

Active Publication Date: 2021-03-19
宁波泰一健康产业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Currently developed oral micro-effervescent tablets mainly use magnesium stearate, dextrin, silicon dioxide, hydroxypropylmethylcellulose, etc. Good, can not fill the whole mouth, affect the absorption of functional substances and other deficiencies

Method used

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  • Oral micro-effervescent granules and preparation method thereof
  • Oral micro-effervescent granules and preparation method thereof
  • Oral micro-effervescent granules and preparation method thereof

Examples

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preparation example Construction

[0057] The present invention also provides a preparation method of the above-mentioned oral micro-effervescent granules, comprising the following steps:

[0058] Separately prepare acid granules and alkali granules;

[0059] mixing the acid granules and base granules;

[0060] Wherein, preparing the acid granules refers to mixing the components of the acid granules and then pulverizing and sieving or mixing them after pulverizing and sieving separately, and performing the first boiling granulation;

[0061] The preparation of the alkali granules means that the components of the alkali granules are mixed and then pulverized and sieved or separately pulverized and sieved and then mixed to perform the second boiling granulation.

[0062]In one example, the process conditions for the first boiling granulation include: material temperature 30°C-50°C, fan frequency 15Hz-30Hz, liquid supply speed 8rpm-20rpm, atomization pressure 0.2Mpa-0.5Mpa;

[0063] The technical conditions of t...

Embodiment 1～3

[0067] The present embodiment provides 3 kinds of oral micro-effervescent granules, the formula of which is shown in Table 1 (mass percentage):

[0068] Table 1

[0069]

[0070] The preparation method of above-mentioned oral micro-effervescent granule is as follows:

[0071] (1) Pulverize nutrients, sugar alcohols, fruit powder, sweetener, starch and acid source, pass through an 80-mesh sieve, and mix for later use;

[0072] (2) Preparation of adhesive: with pure water As a solvent, the adhesive is prepared into an adhesive solution with a mass concentration of 1%, and natural pigments are added;

[0073] (3) Boiling granulation: mixing the materials in steps (1) and (2) for boiling granulation, the conditions are as follows: material temperature 40°C, fan frequency 20Hz, liquid supply speed 15rpm, atomization pressure 0.3Mpa; then 40 mesh sieve Whole grain; get acid grain;

[0074] (4) Steps (1) to (3) prepare alkali granules in the same way;

[0075] (5) A gravity-f...

Embodiment 4-8

[0077] Granulation with different starches or dextrins. The formulations of oral micro-effervescent granules provided in Examples 4-8 are the same as those in Example 1, except that the starch used is different, which are maltodextrin, corn starch, resistant dextrin, modified starch and pregelatinized starch.

[0078] The formula is specifically shown in the following table 2 (mass percentage):

[0079] Table 2

[0080]

[0081]

[0082] The preparation method of above-mentioned oral micro-effervescent granule is as follows:

[0083] (1) Pulverize nutrients, sugar alcohols, fruit powder, sweetener, starch and acid source, pass through an 80-mesh sieve, and mix for later use;

[0084] (2) Preparation of adhesive: with pure water As a solvent, the adhesive is prepared into an adhesive solution with a mass concentration of 1%, and natural pigments are added;

[0085] (3) Boiling granulation: mixing the materials in steps (1) and (2) for boiling granulation, the conditio...

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Abstract

The invention relates to oral micro-effervescent granules and a preparation method thereof. The oral cavity micro-effervescent granules comprise acid granules and alkali granules. The oral cavity micro-effervescent granules comprise the following components in percentage by mass of 15%-25% of functional components, 40%-70% of sugar alcohol, 5%-15% of starch, 4%-16% of an acid source / alkali sourceand 0.5%-2% of an adhesive. The oral cavity micro-effervescent granules are short in disintegration time in the oral cavity, and can form proper and dense foams to fill the whole oral cavity, therebybeing beneficial to absorption of functional substances.

Description

technical field [0001] The invention relates to a dosage form of a health care product, in particular to an oral micro-effervescent granule and a preparation method thereof. Background technique [0002] Traditional dosage forms such as solid beverages, oral liquids, capsules, and tablets are the mainstream in the health care products and functional food markets. These dosage forms more or less have some areas to be improved, such as: solid beverages need to be washed with water, and usage scenarios are limited ; Oral liquid is bulky and not easy to carry; capsules have the risk of throat jam when swallowing, and are not suitable for children and the elderly; tablets disintegrate and absorb slowly in the oral cavity. Effervescent tablet is a relatively new dosage form, which uses the reaction of acid source and alkali source to generate a large amount of carbon dioxide gas, so as to quickly disintegrate and disperse functional substances. Effervescent tablets have the advan...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K47/36A61K47/26A61K47/12A61K47/02A23P10/20
CPCA61K9/1623A61K9/1652A61K9/1617A61K9/1611A61K9/1694A61K9/0007A61K9/0056A23P10/20
Inventor 王罡王琳珺邹小华孙振蛟
Owner 宁波泰一健康产业有限公司
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