Hydrophilic shape memory hydrogel serving as artificial lens material

An intraocular lens, hydrophilic technology, applied in the fields of prosthesis, medical science, tissue regeneration, etc., can solve the problems of easily induced post-onset cataract, eccentric displacement, glare, etc., to reduce post-onset cataract, avoid damage, and recover. visual effect

Active Publication Date: 2016-05-04
HARBIN INST OF TECH
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  • Abstract
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  • Claims
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Problems solved by technology

[0006] The purpose of the present invention is to solve the problems of glare, eccentric shift and easy induction of posterior cata...

Method used

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Experimental program
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specific Embodiment approach 1

[0011] Embodiment 1: In this embodiment, a hydrophilic shape memory hydrogel as an intraocular lens material is made of polymerized monomers and initiators; wherein the polymerized monomers are hydroxyethyl methacrylate, 2-benzene Oxyethyl acrylate, polyethylene glycol methacrylate and triethylene glycol diacrylate; the initiator is azobisisobutyronitrile; the amount of polyethylene glycol methacrylate accounts for the total mass of polymerized monomers The amount of triethylene glycol diacrylate accounted for 1.0% to 5.0% of the total mass of polymerized monomers; the total amount of 2-phenoxyethyl acrylate and hydroxyethyl methacrylate accounted for 70%~100% of the total mass of monomers, the mass ratio of 2-phenoxyethyl acrylate and hydroxyethyl methacrylate is 1:(3~9); the amount of initiator accounts for the total mass of polymerized monomers 0.1% to 1.0%.

specific Embodiment approach 2

[0012] Embodiment 2: This embodiment differs from Embodiment 1 in that the amount of polyethylene glycol methacrylate accounts for 10% of the total mass of the polymerized monomers. Others are the same as in the first embodiment.

specific Embodiment approach 3

[0013] Embodiment 3: This embodiment is different from Embodiment 1 in that the amount of polyethylene glycol methacrylate accounts for 20% of the total mass of the polymerized monomers. Others are the same as in the first embodiment.

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Abstract

The invention discloses a hydrophilic shape memory hydrogel serving as an artificial lens material, belonging to the field of biomedical materials. The invention aims at solving the problems of glare, eccentric displacement and easy induction of after cataract of the existing foldable artificial lenses. The hydrophilic shape memory hydrogel is prepared from a polymeric monomer and an initiator, wherein thepolymeric monomer refers to hydroxyethyl methacrylate, 2-phenoxyethyl acrylate, polyethylene glycolmethacrylate and triethylene glycoldiacrylate; and the initiator is azodiisobutyronitrile. The hydrophilic shape memory hydrogel disclosed by the invention serves as the artificial lens material, the equilibrium moisture content is over 30%, the refraction index is greater than 1.4, the light transmittance can go beyond 90%, the deformation recovery rate exceeds 96%, and the mechanical and optical properties are good; and the artificial lens can simulate a normal human lens in diameter and thickness, thus the whole lens capsule can be filled withthe implanted artificial lensto effectively reduce the complications such as after cataract, glare and eccentric displacement of artificial lens.

Description

technical field [0001] The invention belongs to the field of biomedical materials, in particular to an artificial lens material. Background technique [0002] Cataract is a common eye disease, manifested as opacity of the lens itself or the lens capsule. Up to now, there is still no effective medicine that can completely cure it. Only surgery (ie cataract extraction + intraocular lens implantation) can be used to restore the patient's vision. It has been more than 60 years since the intraocular lens came out in 1949. According to the hardness, it can be divided into hard intraocular lens and soft intraocular lens. The earliest rigid intraocular lens was mainly made of polymethyl methacrylate, which has a refractive index, light weight, and is not easily broken. It is a hydrophobic material with stable performance and is resistant to aging and environmental changes. Alkali, resistant to organic solvents. However, because it is a hard material, it can sometimes cause mechani...

Claims

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Application Information

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IPC IPC(8): A61L27/18A61L27/52A61L27/50
CPCA61L27/18A61L27/50A61L27/52A61L2400/16A61L2430/16
Inventor 冷劲松刘彦菊黄信佐魏洪秋
Owner HARBIN INST OF TECH
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