Florfenicol slow-release dispersoid and preparation method thereof

Abstract

The invention relates to florfenicol slow-release dispersoid and a preparation method thereof. The florfenicol slow-release dispersoid is prepared from, by mass, 10-50% of florfenicol, 2-20% of carboxymethyl cellulose sodium, 20-60% of polyethylene glycol-6000 and 5-20% of polyvidone. The preparation method includes the following steps of firstly, sufficiently and evenly stirring raw materials according to the proportion; secondly, adding water to form suspension so that carriers and medicines can be sufficiently mixed; thirdly, melting the carriers through a spray-drying method to wrap the medicines, and obtaining the florfenicol slow-release dispersoid. The florfenicol slow-release dispersoid can be completely dissolved in water, has high bioavailablity, a high dissolution rate and a slow-release effect, can be clinically used for mixed materials or drinking water, and can reduce the use amount of clinical medicine and drug resistance.

Description

technical field [0001] The invention relates to a florfenicol sustained-release dispersion and a preparation method thereof, belonging to a new dosage form of veterinary drug solid dispersion. Background technique [0002] Dispersion refers to a dispersion system in solid form formed by highly dispersing drugs in solid carriers, and is mainly used to accelerate and increase the dissolution of insoluble drugs and improve their bioavailability. At present, 90% of veterinary drugs in clinical use are administered in the form of dispersion, which has the advantages of simple production process, convenient packaging and transportation, and can be administered by mixing materials or drinking water, which can reduce labor costs for production enterprises and breeding industries. and production costs. [0003] With the vigorous development of the veterinary drug industry, new veterinary drug preparations are continuously used in clinical practice, among which sustained-release soli...

AI Technical Summary

Problems solved by technology

There is a patent report that florfenicol is made into a nanoemulsion, which improves the utilization rate of the drug and has a certain slow-release effect. However, organic solvents such as dimethylformamide and ethanol need to be added during the production process, which is harmful to the respiratory tract of livestock and poultry. Certain irritation, coupled with high requirements for the production process, so the wide use is subject to certain restrictions

[0005] There have been patent reports that florfenicol soluble powder was made by wrapping florfenicol with molten polyethylene glycol, and the water solubility was improved, but there were problems such as long melting time between the drug and the carrier, uneven stirring, and drug decomposition.

In recent years, it has been reported in the literature that florfenicol is prepared into sustained-release capsules or sustained-release granules. During the preparation process, there are problems such as strict operating procedures and many steps, which are not suitable for large-scale promotion and use. The development and application of florfenicol sustained-release dispersions are rarely reported in China. Therefore, a kind of florfenicol dispersion preparation with high water solubility and sustained release effect is prepared to improve the bioavailability of the drug and expand the clinical use of the drug. is very necessary

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