Biodegradable high molecular gel medicine composition, its prepn. method and use thereof
A polymer gel and biodegradation technology, applied in the field of medical polymer materials, can solve the problems of low drug packaging rate, troublesome clinical application, and unsatisfactory biodegradable gel drug carrier, etc., and achieve the effect of large volume change range.
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Embodiment 1
[0037] Example 1: 20g malic acid was mixed with 2g SnCl at 100°C and 100mmHg vacuum 2 For catalyst polycondensation for 120 hours, the resulting polymer was dissolved in tetrahydrofuran, filtered to remove SnCl 2 According to the ratio of malic acid unit: HEMA: DCC = 5: 1: 1.2, HEMA was grafted onto the side group of polymalic acid. The grafting reaction was carried out under stirring at -20°C, and the reaction time was 100 hours. The grafted solution was filtered, and the filtrate was concentrated, precipitated in ether, and dried under vacuum at room temperature for 24 hours. Dissolve 5 g of dried polymalic acid in 20 g of distilled water, add 1.5 g of camptothecin and 0.05 g of photoinitiator 2959, and irradiate under a UV lamp for 1 hour. The intensity of the UV light is 0.1 mW / cm 2 , the biodegradable polymer gel pharmaceutical composition containing camptothecin can be obtained.
Embodiment 2
[0038] Embodiment 2: 20g malic acid is under 130 ℃ and 0.01mmHg vacuum, catalyst-free polycondensation 1 hour, the polymkeric substance obtained is dissolved in N, N-dimethylformamide, press malic acid unit: HEMA: DCC=5 HEMA was grafted onto the side group of polymalic acid at a ratio of 5:5, and the grafting reaction was carried out under stirring at 100° C., and the reaction time was 100 hours. The grafted solution was filtered, and the filtrate was concentrated, precipitated in ether, and dried under vacuum at room temperature for 24 hours. Dissolve 5 g of dried polymalic acid in 20 g of distilled water, add 2.5 g of paclitaxel and 0.5 g of photoinitiator 369, and irradiate under a UV lamp for 120 seconds. The intensity of the UV light is 16 mW / cm 2 , the biodegradable polymer gel pharmaceutical composition containing the drug paclitaxel can be obtained.
Embodiment 3
[0039] Embodiment 3: With 20g citric acid and 20gPEG (weight average molecular weight is 400) under 250 ℃ and 0.01mmHg vacuum, take 0.2gZnO as catalyst polycondensation 50 hours, the polymkeric substance obtained is dissolved in N,N-dimethylethylene Amide, according to the ratio of citric acid unit: HEMA: DCC = 10: 1: 1.5, HEMA is grafted to the side group of the citric acid and PEG copolymer, and the grafting reaction is carried out under stirring at room temperature, and the reaction time is 36 hours. The grafted solution was filtered, and the filtrate was concentrated, precipitated in ether, and dried under vacuum at room temperature for 24 hours. Dissolve 20g of the dried copolymer in 100mL N, N-dimethylacetamide, add 10g of 5-fluorouracil and 0.5g of photoinitiator 651, and irradiate for 10 minutes under a UV lamp. The intensity of the UV light is 200mW / cm 2 , the biodegradable polymer gel pharmaceutical composition containing the drug 5-fluorouracil can be obtained.
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