Composition for supplementing iron and vitamins for children and preparation method and application of composition

A vitamin and composition technology, which is applied to the composition of iron supplementation and vitamin for children and the field of preparation thereof, can solve the problems of unreasonable dosage of nutrients, decreased ferrous iron content, large gastrointestinal irritation, etc., and achieves improved bioavailability. degree, stable ferrous iron content, and the effect of prolonging the shelf life

Inactive Publication Date: 2016-05-25
湖南知达医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these iron supplements are more irritating to the gastrointestinal tract, and may cause side effects such as nausea, vomiting, constipation, diarrhea, teeth, and stools, and the taste is poor
Therefore, in order to improve the side effects of such iron supplements, people have developed iron supplements compounded with traditional Chinese medicine and ferrous gluconate. For example, Chinese patent application CN1105567A discloses a kind of iron-zinc amino acid nutritional supplement for children. extracts, malt extract, Divine Comedy extract, hydrolyzed animal protein, zinc gluconate, ferrous gluconate, taurine, vitamin propionate magnesium, sucrose and preservatives, but it contains preservatives, which is harmful to health, and its Iron supplementation effect and system stability need to be improved
[0007] At the same time, the iron in iron supplements must be in the form of divalent iron ions to be easily absorbed by the body. However, ferrous ions are easily oxidized. Therefore, the current iron supplements need to be kept in a sealed and sealed form, especially for oral administration of iron supplements. After long-term storage, the content of ferrous iron will drop significantly, and sediment will appear
[0008] Therefore, in view of the problems of poor taste, large side effects, unreasonable dosage of nutrients, poor product stability, and low bioavailability of iron and vitamins in current iron supplements, it is necessary to develop a kind of iron supplement with reasonable composition, good taste, no Side effects, good stability, effectively supplement iron and vitamin composition of iron and vitamin for children, and the composition can be used as a health product for preventing and improving nutritional anemia

Method used

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  • Composition for supplementing iron and vitamins for children and preparation method and application of composition
  • Composition for supplementing iron and vitamins for children and preparation method and application of composition
  • Composition for supplementing iron and vitamins for children and preparation method and application of composition

Examples

Experimental program
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Effect test

Embodiment 1

[0031] Embodiment 1, children's iron and vitamin composition capsules of the present invention

[0032] Formula: ferrous gluconate 0.7g / kg, vitamin B 1 30mg / kg, vitamin B 2 30mg / kg, vitamin B 6 40mg / kg, niacin 110mg / kg, pantothenic acid 80mg / kg, vitamin E 180mg / kg, L-lysine 22mg / kg, citric acid 1g / kg, glucose 200g / kg, supplementary materials 1kg. The auxiliary material is composed of starch, dextrin and magnesium stearate in a weight ratio of 45:44:1.

[0033] Preparation method: take ferrous gluconate and vitamin B 1 , Vitamin B 2 , Vitamin B 6 , nicotinic acid, pantothenic acid, vitamin E, L-lysine, citric acid and glucose, respectively pulverized and passed through a 100-mesh sieve, mixed with equal amount incremental addition method and then mixed with auxiliary materials, filled into capsules to obtain the present invention Composition capsules of iron supplementation and vitamins for children.

Embodiment 2

[0034] Example 2, Composition Granules of Iron and Vitamin Supplementation for Children of the Present Invention

[0035] Formula: ferrous gluconate 1.8g / kg, vitamin B 1 9mg / kg, vitamin B 2 9mg / kg, vitamin B 6 7mg / kg, niacin 330mg / kg, pantothenic acid 22mg / kg, vitamin E 76mg / kg, L-lysine 200mg / kg, citric acid 3g / kg, glucose 600g / kg, supplementary materials 1kg. The auxiliary material is composed of starch and hydroxypropyl methylcellulose according to the weight ratio of 80:20.

[0036] Preparation method: take ferrous gluconate and vitamin B 1 , Vitamin B 2 , Vitamin B 6 , niacin, pantothenic acid, vitamin E, L-lysine, citric acid and glucose, respectively crushed and sieved through a 100-mesh sieve, mixed with equal volume addition method and then mixed with excipients, dry granulated, granulated, that is Obtain the composition granule of iron supplementation and vitamin for children of the present invention.

Embodiment 3

[0037] Embodiment 3, the composition oral liquid of iron supplementation and vitamin for children of the present invention

[0038] Formula: ferrous gluconate 1.2g / kg, vitamin B 1 28mg / kg, vitamin B 2 25mg / kg, vitamin B 6 36mg / kg, niacin 240mg / kg, pantothenic acid 64mg / kg, vitamin E 130mg / kg, L-lysine 160mg / kg, citric acid 2g / kg, glucose 200g / kg, pure water supplement 1kg.

[0039] Preparation method: take ferrous gluconate and vitamin B 1 , Vitamin B 2 , Vitamin B 6 , niacin, pantothenic acid, vitamin E, L-lysine, citric acid and glucose, respectively crushed and sieved through a 100-mesh sieve, mixed in equal amounts, added pure water, stirred evenly, filtered, potted, extinguished Bacteria, lamp inspection, packaging, promptly obtain the oral liquid of the composition oral liquid of iron supplementation and vitamin for children of the present invention.

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Abstract

The invention belongs to the technical field of health care products, and particularly relates to a composition for supplementing iron and vitamins for children and a preparation method and application of the composition. The composition for supplementing the iron and the vitamins for the children is mainly prepared from ferrous gluconate, vitamin B1, vitamin B2, vitamin B6, nicotinic acid, pantothenic acid, vitamin E, L-lysine, citric acid, a sweetening agent and auxiliary materials. The composition for supplementing iron and vitamins for the children is designed for the children and is scientific in matching, good in mouthfeel, free of side effects and capable of effectively supplementing the needed trace element iron and vitamin B for the children; meanwhile, the composition is high in stability and long in preservation period and can serve as a health care product for preventing and improving nutritional anemia.

Description

technical field [0001] The invention belongs to the technical field of health care products, and in particular relates to a composition of iron supplementation and vitamins for children, a preparation method and application thereof. Background technique [0002] Iron is one of the trace elements necessary for the human body with the largest content, known as semi-trace elements, the total amount is about 4~5g. Iron is one of the main raw materials for the synthesis of hemoglobin in the human body. The function of hemoglobin is mainly to transport oxygen to various tissues and organs, and transport carbon dioxide produced in tissue metabolism to the lungs for excretion. Iron is also the carrier of some enzymes and electron transfer in the redox reaction system in the human body, and is also an important component of catalase and cytochrome. Iron deficiency can reduce hemoglobin content and physiological activity, causing a significant reduction in the oxygen carried, thereb...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/525A61K36/734A61P3/02A61P7/06A61K31/191A61K31/51A61K31/4415A61K31/455A61K31/197A61K31/355A61K31/198
CPCA61K33/26A61K9/0053A61K9/08A61K9/1623A61K9/1652A61K9/4858A61K31/197A61K31/198A61K31/355A61K31/4415A61K31/455A61K31/51A61K31/525A61K36/185A61K36/734A61K47/26A61K2300/00
Inventor 卞国良李君佩赵振伟
Owner 湖南知达医药科技有限公司
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