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Novel application of notoginsenoside R4 to preparation of medicine for treating and/or preventing allergic rhinitis

A technology for allergic rhinitis and Panax notoginseng saponins, which is applied in the field of new uses of Panax notoginseng saponins R4 in the preparation of drugs for treating and/or preventing allergic rhinitis, can solve the problem of not finding allergic rhinitis and the like, and achieves a simple preparation method , The effect of obvious pharmacological effect and easy availability of raw materials

Active Publication Date: 2016-06-01
GUANGXI WUZHOU PHARMA GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Notoginseng saponin R has not been retrieved so far 4 Literature reports for the treatment or prevention of allergic rhinitis

Method used

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  • Novel application of notoginsenoside R4 to preparation of medicine for treating and/or preventing allergic rhinitis
  • Novel application of notoginsenoside R4 to preparation of medicine for treating and/or preventing allergic rhinitis
  • Novel application of notoginsenoside R4 to preparation of medicine for treating and/or preventing allergic rhinitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Take the notoginseng medicinal material and crush it into fine powder, heat and reflux extraction with 50% ethanol by volume, the notoginseng extract passes through the HPD-100 type macroporous adsorption resin with 12 times the weight of notoginseng at a flow rate of 18BV / h, and use 75% by volume Ethanol elution, eluent concentration, Panax notoginseng total saponin concentrated solution passes through 8 times the weight of Panax notoginseng Rp-C18 silica gel column at a flow rate of 10BV / h, isocratic elution with methanol-water, online detection of Panax notoginseng in the eluent Saponin R 4 content, collect qualified parts (on-line monitoring, the part that meets the requirements of the present invention is the qualified part), concentrate and dry to get final product.

[0023] After testing, notoginseng saponin R 4 The content is 85%.

Embodiment 2

[0025] Take the notoginseng medicinal material and crush it into fine powder, heat and reflux extraction with 95% ethanol by volume, the notoginseng extract passes through the HPD-100 type macroporous adsorption resin 10 times the weight of notoginseng at a flow rate of 16BV / h, and use 95% by volume Ethanol elution, eluent concentration, Panax notoginseng total saponin concentrated liquid passes through 8 times the weight of Panax notoginseng Rp-C18 silica gel column at a flow rate of 8BV / h, isocratic elution with methanol-water, online detection of Panax notoginseng in the eluent Saponin R 4 content, collect qualified parts (on-line monitoring, the part that meets the requirements of the present invention is the qualified part), concentrate and dry to get final product.

[0026] After testing, notoginseng saponin R 4 The content is 70%.

Embodiment 3

[0028] Get embodiment 1 gained notoginseng saponin R 4 20g, microcrystalline cellulose 10g, magnesium stearate 5g, lactose 120g; mix the raw materials except magnesium stearate evenly, moisten with water, pass through a 18-mesh sieve, dry, then pass through a 20-mesh sieve again, add stearin Magnesium acid, mixed uniformly and then pressed into tablets to obtain tablets.

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Abstract

The invention relates to novel application of notoginsenoside R4, namely novel application of the notoginsenoside R4 to preparation of medicine for treating and / or preventing allergic rhinitis.It is proved by experiments that the notoginsenoside R4 can improve symptoms of allergic rhinitis on multiple aspects, and a quite good effect is achieved on the aspects of lowering the content of blood histamine and repairing nasal mucosa.

Description

technical field [0001] The present invention relates to notoginsenoside R 4 A new application of, specifically notoginseng saponin R 4 The new application in preparing medicines for treating and / or preventing allergic rhinitis. Background technique [0002] Allergic rhinitis (allergicrhinitis, AR) is a susceptible body exposed to sensitizing allergens, which results in the release of inflammatory mediators mainly mediated by IgE and a variety of immune active cells and inflammatory cytokines. Infectious inflammatory disease. The prevalence of allergic rhinitis in the world is on the rise. The prevalence of allergic rhinitis in adults in European and American countries is generally 10%-25%. In recent years, the number of outpatients in my country has increased significantly, which has seriously affected the quality of life of patients. Allergic rhinitis is a multifactorial disease induced by the interaction of genes and environment. Risk factors for allergic rhinitis may ...

Claims

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Application Information

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IPC IPC(8): A61K31/704A61K36/258A61P11/02A61P37/08
CPCA61K9/0019A61K9/08A61K9/19A61K9/2054A61K9/4858A61K31/704A61K36/258A61K47/02A61K2236/333A61K2236/55
Inventor 邱丹兰黄源春刘冠萍林艳英杨北妮谭喜梅
Owner GUANGXI WUZHOU PHARMA GRP
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