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Biological scaffold manufacturing method based on 3D printing and biological scaffold

A bio-scaffold and 3D printing technology, applied in the direction of digital output to printing unit, drug delivery, pharmaceutical formulation, etc., can solve the problems of single micropore, repetitive structure, unfavorable cell growth, etc., achieve simple and fast production method, and meet production needs Effect

Active Publication Date: 2016-06-01
SHENZHEN EXCELLENT TECH
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Problems solved by technology

[0005] In view of the above-mentioned deficiencies in the prior art, the purpose of the present invention is to provide a bioscaffold manufacturing method based on 3D printing and a bioscaffold, aiming to solve the problem that most of the bioscaffolds produced in the prior art have single micropores, repeated structures and large pore sizes. consistent, detrimental to cell growth issues

Method used

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  • Biological scaffold manufacturing method based on 3D printing and biological scaffold
  • Biological scaffold manufacturing method based on 3D printing and biological scaffold
  • Biological scaffold manufacturing method based on 3D printing and biological scaffold

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Embodiment Construction

[0027] The present invention provides a method and system for manufacturing biological scaffolds based on 3D printing. In order to make the purpose, technical solution and effect of the present invention more clear and definite, the present invention will be further described in detail below. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention.

[0028] Such as figure 1 Shown, the present invention provides a kind of bioscaffold manufacturing method based on 3D printing, and it comprises the following steps:

[0029] S100. According to the growth requirements of different cells, select the porosity, wire diameter, shape and surface area of ​​the cell scaffold in the preset human body digital library, establish a three-dimensional model with pores, and save it;

[0030] S200, importing the three-dimensional model into a computer control system connected with the 3D bioprinter, a...

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Abstract

The invention provides a biological scaffold manufacturing method based on 3D printing and a biological scaffold. The method comprises the following steps: observing and analyzing different cell tissues; manufacturing a 3D structure capable of supporting a cell scaffold by adopting a water-soluble material; filling all inner pores of the 3D structure with a biodegradable material; and then, putting in a water solution for dissolving and removing the water-soluble material, thereby obtaining the biological scaffold composed of the biodegradable material. The pore diameters of the inner pores of the manufactured biological scaffold are different, thereby being favorable for growth of cells; and the biological scaffold manufacturing method based on 3D printing is simple and quick and is capable of meeting the manufacturing requirements.

Description

technical field [0001] The invention relates to the field of 3D manufacturing of biological scaffolds, in particular to a method for manufacturing biological scaffolds based on 3D printing and biological scaffolds. Background technique [0002] One of the key technologies of tissue engineering is to prepare multi-dimensional porous cell scaffolds (extracellular matrix substitutes) with specific shapes and connected pore structures through biomaterials with good biocompatibility and biodegradable absorption properties. The pore shapes of tissue engineering porous scaffolds mainly include fiber, porous sponge / foam, etc. Correspondingly, the pore-forming methods and techniques are also different. Fibrous scaffolds are one of the earliest extracellular matrix substitutes used in tissue engineering research. They are mainly composed of crystalline polymer fibers such as PGA or its copolymers. Independent adjustment; the traditional methods of porous foam / sponge scaffolds mainly ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/56A61L27/50G06F3/12B33Y50/02
CPCA61L27/50A61L27/56A61L2400/08B33Y50/02G06F3/1219
Inventor 赵小文张东锋赵文平蔡君华
Owner SHENZHEN EXCELLENT TECH
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