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Nicergoline capsule and preparation method thereof

A technology for preparing nicergoline and capsules, applied in the field of medicine, can solve the problems of chronic brain dysfunction, complex and tedious preparation process, poor patient compliance, etc., and achieves the effects of good compliance, good curative effect and less side effects

Active Publication Date: 2016-06-08
CHINA MEHECO SANYANG PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

2. Chronic brain insufficiency (cognitive deficits, physical symptoms, and psychoemotional disturbances)
The above-mentioned dosage forms currently on the market use many kinds of excipients in the preparation process, the production cost is high, the preparation process is complicated and cumbersome, the side effects are obvious in clinical application, and the compliance of patients to take medicine is very poor.

Method used

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  • Nicergoline capsule and preparation method thereof
  • Nicergoline capsule and preparation method thereof
  • Nicergoline capsule and preparation method thereof

Examples

Experimental program
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Effect test

preparation example Construction

[0067] (1) Preparation of parent pill: add hypromellose in ethanol (medicinal), stir and disperse, add purified water, make hypromellose binder, stir until clarified, for subsequent use; Nicergoline Mix evenly with starch in the mixer, take part of the uniformly mixed powder and add it to the pellet machine, add the above-mentioned adhesive in a proper amount by spraying, so that the powder will gradually form mother pellets.

[0068] (2) Master pellet enlargement (preparation of pellet core): after the powder material forms the master pellet, gradually add the remaining powder to it, and at the same time add the remaining binder by spraying. When the size of the master pellet reaches the predetermined requirement, Convey ordinary wind to it to polish and dry the ball cores. The prepared ball cores pass through 24 and 40 mesh sieves in turn, and the finished balls are between 24-40 mesh sieves. After the finished balls are dried, the ball cores are obtained.

[0069] (3) Prepa...

Embodiment 1

[0077] Nicergoline capsules (15mg), consisting of:

[0078]

[0079] The preparation method of Nicergoline Capsules:

[0080] (1) Preparation of mother pill: 2g hypromellose is added in 10g ethanol, stirs and disperses, adds 25g purified water, is made into hypromellose binder, stirs to clarification, for subsequent use; 15g nicergoline Mix 30 minutes with 190g starch in mixer, make Nicergoline and starch mix homogeneously; Get the powder material that 45.1g mixes homogeneously and add in the pill-making machine, turntable frequency is 20HZ, adds 8.1g binding agent with spray mode, The pressure of the spray gun is set to 0.2MPa, so that the powder gradually forms the master shot.

[0081] (2) Mother shot enlargement (pill core preparation): After the powder material forms the mother shot, keep the frequency of the turntable at 20HZ, gradually add the remaining powder to it, and at the same time add the remaining binder by spraying (the pressure of the spray gun is set to 0...

Embodiment 2

[0106] Nicergoline capsules (15mg), consisting of:

[0107]

[0108]

[0109] The preparation method of Nicergoline Capsules:

[0110] (1) Preparation of parent pills: add 2.5g hypromellose to 11g ethanol, stir and disperse, add 26.5g purified water to make hypromellose binder, stir until clear, and set aside; Ergoline and 195g of starch were mixed in a mixer for 35 minutes to make Nicergoline and starch evenly mixed; 48.3g of uniformly mixed powder was taken and added to the pellet machine, the frequency of the turntable was 35HZ, and 9.2g of adhesive was added by spraying. agent, the pressure of the spray gun is set to 0.2MPa, so that the powder gradually forms a master shot.

[0111] (2) Mother shot enlargement (pill core preparation): After the powder material forms the mother shot, keep the frequency of the turntable at 35HZ, gradually add the remaining powder to it, and at the same time add the remaining binder by spraying (the pressure of the spray gun is set to ...

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Abstract

The invention relates to the technical field of medicine, in particular to a nicergoline capsule and a preparation method thereof. The preparation method is characterized in that first, nicergoline and starch are mixed to be uniform, then a binder is added to be prepared into a mother pill, and finally a pill core is prepared; in the whole preparation process, the adopted kinds of auxiliary materials are fewer (2 kinds of auxiliary materials), the preparation process is simple, operation is easy, the pill core is good in fluidity, filling is easy, meanwhile, the main drug dissolution rate is high, the curative effect in clinical application is good, the side effects are fewer, and the compliance of a patient taking the medicine is good; according to similar kinds of medicine sold on the market, a large number of kinds of auxiliary materials are adopted, the preparation process is complicated, operation is hard, the curative effect in clinical application is poor, a large number of side effects are produced, and the compliance of the patient taking the medicine is poor. It shows that according to the novel nicergoline capsule and the preparation method thereof, the quality performance of the product is good, and medication safety of the patient is ensured.

Description

technical field [0001] The invention relates to the technical field of medicines, in particular to nicergoline capsules and a preparation method thereof. Background technique [0002] At present, my country's elderly population has exceeded 200 million, and is growing at an average annual rate of 5.4%. The increasing number of elderly population increases the rate of suffering from cerebrovascular diseases. Paralysis, aphasia and dementia caused by cerebrovascular diseases have further aggravated the social and family burden. Due to the increasing number of patients, the market demand for drugs for the treatment of acute and chronic cerebrovascular diseases and sequelae of cerebrovascular diseases continues to grow steadily. In cerebrovascular diseases, before irreversible damage occurs to the nerve tissue, timely application of neuroprotective agents can reduce the volume of cerebral infarction and promote the recovery of neurological function. Such drugs include calcium c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K31/48A61K47/38A61K47/36A61P9/00A61P9/10A61P25/00
CPCA61K9/1652A61K31/48
Inventor 王玉娟朱峰李锦云
Owner CHINA MEHECO SANYANG PHARMA CO LTD
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