Non-covalently modified graphene field effect transistor-based tumor marker detection sensor and production method thereof

A non-covalent modification and tumor marker technology, which is applied in the field of tumor marker detection sensors and its preparation, can solve the problems of complex detection and analysis process and time-consuming, etc., and achieve the advantages of easy manufacturing process, strong versatility, and excellent electrical performance Effect

Inactive Publication Date: 2016-06-08
SHANGHAI INST OF MICROSYSTEM & INFORMATION TECH CHINESE ACAD OF SCI
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  • Abstract
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  • Application Information

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Problems solved by technology

[0007] The technical problem to be solved by the present invention is to provide a tumor marker detection sensor based on a non-covalently modified graphene field effect tube and a preparation method thereof. And it can realize real-time, specific, high-sensitivity and low-cost detection

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  • Non-covalently modified graphene field effect transistor-based tumor marker detection sensor and production method thereof
  • Non-covalently modified graphene field effect transistor-based tumor marker detection sensor and production method thereof
  • Non-covalently modified graphene field effect transistor-based tumor marker detection sensor and production method thereof

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Embodiment 1

[0037] Such as figure 2 Shown is a schematic diagram of a real-time detection system of a tumor marker detection sensor based on a non-covalently modified graphene field effect tube. The process flow of the non-covalently modified graphene field effect tube is to thermally oxidize a layer of 300nm silicon dioxide 2 on a silicon substrate 1, and make it on the surface of the silicon dioxide through a lift-off process and an electron beam evaporation process The metal electrodes composed of 10nm titanium and 30nm gold are used as the drain terminal 3 and source terminal 4 of the graphene field effect tube. The graphene film is transferred to the surface of the metal electrode by a wet transfer method, and the graphene is transferred with acetone. The PMMA glue on the surface is dissolved, leaving graphene on the surface of the metal electrode, and then forming a graphene channel 7 (length 60μm, width 30μm) by photolithography and plasma etching, which is deposited on the gold ele...

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Abstract

The invention relates to a non-covalently modified graphene field effect transistor-based tumor marker detection sensor and a production method thereof. The sensor comprises a silica substrate, a graphene channel and a reaction chamber. The production method comprises the following steps: making a metal electrode, carrying out wet transfer on graphene, making the graphene channel and a protection insulation layer of the graphene channel, and modifying the surface of graphene in a non-covalent mode. The sensor has the advantages of convenient making process, simple modification process, easy operation, and high sensitivity and good specificity in application; and the making method can also be used to make most of biosensors of capture probes with amino groups, and the sensor is used to detect target molecules.

Description

Technical field [0001] The invention belongs to the field of biosensors, and particularly relates to a tumor marker detection sensor based on a non-covalently modified graphene field effect tube and a preparation method thereof. Background technique [0002] According to the World Health Organization’s “World Cancer Report”, cancer has become the world’s largest cause of death, with morbidity and mortality rates continuing to rise. The report predicts that global cancer cases will show a rapid growth trend. Cancer is expected to be in 2035. The number of cases may increase year by year from 14 million in 2012 to 24 million. China has become the country with the highest incidence of cancer in the world. China's cancer deaths account for about half of the world's deaths, and it is the country with the most cancer deaths in the world. [0003] Early detection of cancer can greatly improve the chances of cancer patients being cured. Breast cancer, cervical cancer, lung cancer, laryng...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/416G01N27/414G01N33/574
CPCG01N27/416G01N27/4145G01N33/57484
Inventor 毛红菊周麟薛德明张宏莲金庆辉赵建龙
Owner SHANGHAI INST OF MICROSYSTEM & INFORMATION TECH CHINESE ACAD OF SCI
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