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Preparation method and application of ferulic acid/chitosan loaded vitamin B1 and vitamin B6 microcapsules

A ferulic acid and vitamin technology is applied in the field of preparation and application of ferulic acid/chitosan-loaded vitamin B1 and vitamin B6 microcapsules, which can solve problems such as difficult absorption and limited application range, and achieve improved stability and Biodegradability and the effect of abundant raw materials

Active Publication Date: 2018-11-06
GUANGXI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, since chitosan is only soluble in acid but not in neutral or alkaline aqueous solution, and is not easily absorbed in the human body, its application range is largely limited.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] A preparation method of ferulic acid / chitosan loaded vitamin B1 and B6 microcapsules, the specific steps are as follows:

[0023] 1) Preparation of ferulic acid / chitosan polymer

[0024] Take 10g of chitosan in a 5L three-neck round bottom flask, add 2L of 1% acetic acid solution to dissolve, and then add 20mL of 1M H 2 o 2 solution, where H 2 o 2 Contain 1.08g ascorbic acid in the solution, then pass N230min in this three-necked round-bottomed flask under continuous stirring, add 100mL ethanol solution that is dissolved with 10g ferulic acid, then this reaction three-necked round-bottomed flask is stoppered and sealed with paraffin, constantly Perform magnetic stirring and react at 40°C for 1.5 hours; finally, the mixed solution is dialyzed with a molecular weight 14,000 dialysis membrane for 72 hours to remove unreacted ferulic acid, and then centrifuged at 10,000 rpm for 30 minutes, and the filtrate is dried with a pilot plant spray dryer. The inlet temperature o...

Embodiment 2

[0028] A preparation method of ferulic acid / chitosan loaded vitamin B1 and B6 microcapsules, the specific steps are as follows:

[0029] 1) Preparation of ferulic acid / chitosan polymer

[0030] Take 15g of chitosan in a 5L three-neck round bottom flask, add 2L of 1% acetic acid solution to dissolve, then add 20mL of 1M H 2 o 2 solution, where H 2 o 2 Contain 1.08g ascorbic acid in the solution, then pass N230min in this three-necked round-bottomed flask under continuous stirring, add 100mL ethanol solution that is dissolved with 15g ferulic acid, then this reaction three-necked round-bottomed flask is stoppered and sealed with paraffin, constantly Perform magnetic stirring and react at 60°C for 3 hours; finally, the mixed solution is dialyzed with a molecular weight 14,000 dialysis membrane for 72 hours to remove unreacted ferulic acid, and then centrifuged at 10,000 rpm for 30 minutes, and the filtrate is dried with a pilot plant spray dryer. The inlet temperature was 140...

Embodiment 3

[0034] A preparation method of ferulic acid / chitosan loaded vitamin B1 and B6 microcapsules, the specific steps are as follows:

[0035] 1) Preparation of ferulic acid / chitosan polymer

[0036] Take 20g of chitosan in a 5L three-neck round bottom flask, add 2L of 1% acetic acid solution to dissolve, then add 20mL of 1M H 2 o 2 solution, where H 2 o 2 Contain 1.08g ascorbic acid in the solution, then pass N230min in this three-necked round-bottomed flask under continuous stirring, add 100mL ethanol solution that is dissolved with 20g ferulic acid, then this reaction three-necked round-bottomed flask is stoppered and sealed with paraffin, constantly Perform magnetic stirring and react at 60°C for 3 hours; finally, the mixed solution is dialyzed with a molecular weight 14,000 dialysis membrane for 72 hours to remove unreacted ferulic acid, and then centrifuged at 10,000 rpm for 30 minutes, and the filtrate is dried with a pilot plant spray dryer. The inlet temperature was 140...

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Abstract

The invention discloses a preparation method and an application of microcapsules with vitamin B1 and vitamin B6 supported by ferulic acid / chitosan. According to the method, a ferulic acid / chitosan polymer is prepared through a free radical mediated reaction, then the microcapsules with the vitamin B6 supported by ferulic acid / chitosan are prepared from ferulic acid / chitosan as a wall material and the vitamin B6 as a core material with a spray drying method. The preparation method and the application have the advantages that the preparation method is simple, convenient and controllable, the materials are widely sourced, the production efficiency is high, the microcapsules with the vitamin B1 and the vitamin B6 supported by ferulic acid / chitosan show good antibacterial activity and excellent controlled release performance, the application of ferulic acid / chitosan as the wall material in dietary supplement and functional food auxiliary materials is broadened, and the microcapsules have good development prospect.

Description

technical field [0001] The invention belongs to the technical field of polymer materials, in particular to the preparation and application of ferulic acid / chitosan-loaded vitamin B1 and vitamin B6 microcapsules. Background technique [0002] In recent years, the research on functional chitosan derivatives is one of the most popular research topics. Due to its biofunctionality, biocompatibility, low toxicity and biodegradability, chitosan is the best choice for microcapsule wall material. However, because chitosan is only soluble in acid but not in neutral or alkaline aqueous solution, and is not easily absorbed in the human body, its application range is largely limited. Therefore, it is necessary to modify the chemical structure of chitosan. Generally, phenolic acid and chitosan are copolymerized to prepare phenolic acid chitosan polymer, thereby improving its solubility and broadening its application range. [0003] Ferulic acid is an important phenolic acid, and it is a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A23L33/15A23L5/00
CPCA23V2002/00A23V2250/7042A23V2250/7052A23V2250/511
Inventor 李坚斌李辰聂卉杨勇刘培华陈雨
Owner GUANGXI UNIV