A kind of preparation method of effervescent tablet
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A technology of effervescent tablets and polyethylene glycol, applied in the field of preparation of pharmaceutical dosage forms, can solve the problems of difficult industrial production, extended shelf life, and short shelf life, and achieve the effect of long shelf life, extended shelf life, and simple method
Inactive Publication Date: 2018-06-01
CENT SOUTH UNIV
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Problems solved by technology
[0004] The present invention aims at the problems of low molding rate, short shelf life and difficulty in coping with industrialized production in the existing effervescent tablets, and provides a new method to overcome the deficiencies in the prior art and make the effervescent tablets produced The surface of the tablet is smooth, the molding rate is high, and the disintegration speed and the release of the active ingredients in the raw materials can be further improved, and the shelf life can be effectively extended; the method is low in raw material cost, simple in method, non-polluting, low in equipment requirements, and can be widely used in industrial production
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Embodiment 1
[0027] 1, the effervescent tablet of the present embodiment, comprises the following raw materials by 3kg as base material: ginger powder 0.06kg, PVP-K300.03kg, sodium bicarbonate 0.30kg, tartaric acid 0.27kg, PEG60000.15kg, salt 2.16kg, micropowder Silica gel 0.03kg, absolute ethanol 0.14L.
[0028] Include the following steps:
[0029] Step 1, heat 0.09kg of PEG6000 to 70°C to dissolve, then dilute with 0.03L of ethanol, coat 0.3kg of sodium bicarbonate, and coat the alkali source with a layer of PEG film for use;
[0030] In step 2, 0.06kg of PEG6000 is heated to 70°C to dissolve, then diluted with 0.02L of ethanol, and 0.27kg of tartaric acid is coated, so that the acid source is coated with a layer of PEG film for use;
[0031] Step 3, fully mixing the coated acid source and alkali source, it is A;
[0032] Step 4, dissolving 0.01kg PVP-K30 with 0.03L dehydrated alcohol, and coating A with it to obtain effervescent particles coated with a double-layer organic film layer...
Embodiment 2
[0039] The effervescent tablet of the present embodiment includes the following raw materials based on 3kg: ginger powder 0.06kg, PVP-K300.06kg, sodium bicarbonate 0.30kg, tartaric acid 0.27kg, PEG40000.15kg, salt 2.13kg, micropowder silica gel 0.03 kg, anhydrous ethanol 0.35L.
[0040] Include the following steps:
[0041] Step 1, heat 0.09kg of PEG4000 to 60°C to dissolve, then dilute with 0.03L of ethanol, coat 0.3kg of sodium bicarbonate, and coat the alkali source with a layer of PEG film for use;
[0042] In step 2, 0.06kg of PEG4000 is heated to 60°C to dissolve, then diluted with 0.02L of ethanol, and 0.27kg of tartaric acid is coated, so that the acid source is coated with a layer of PEG film for use;
[0043] Step 3, fully mixing the coated acid source and alkali source, it is A;
[0044] Step 4, dissolving 0.01kg PVP-K30 with 0.05L absolute ethanol, and coating A with it to obtain effervescent particles coated with a double-layer organic film layer;
[0045] Step...
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Abstract
The invention discloses a preparation method of effervescent tablets. Polyethylene glycol is heated and melted and then is diluted with ethanol, a polyethylene glycol-ethanol solution is formed and then coats an acid source and an alkaline source, and accordingly, acid-source granules coated with polyethylene glycol film layers and alkaline-source granules coated with polyethylene glycol film layers are formed; the acid-source granules and the alkaline-source granules are sufficiently mixed and stirred, a mixture is formed, an ethanol solution of polyvinylpyrrolidone K30 is added to the mixture for secondary coating, a product is crushed after being dried, and effervescent granules coated with double organic film layers are obtained after uniform mixing; main medicine ingredients of a medicine and other acceptable excipients used for preparation of the effervescent tablets are added to the effervescent granules, and the effervescent tablet preparations are obtained through tableting after sufficient mixing. The prepared effervescent tablets are not prone to moisture absorption and deterioration and have good flowability; the forming rate is high, and sticking is avoided; the disintegration is fast. According to the method, adopted raw materials are cheap and easy to obtain, the method is simple, pollution-free and harmless to a human body, has low requirements for equipment and has good application prospect, and industrial production is easily realized.
Description
Technical field: [0001] The invention belongs to the field of preparation of pharmaceutical dosage forms, and in particular relates to a preparation method of an effervescent tablet. Background technique [0002] Effervescent tablet is a special form of pharmaceutical preparation developed and applied abroad in recent years. In addition to the general excipients, it also contains an effervescent disintegrant, that is, the compatibility of bicarbonate such as sodium bicarbonate and solid acid such as tartaric acid or citric acid. When the effervescent tablet is put into water, under the action of bicarbonate and acid, it reacts rapidly to form a large number of air bubbles, so that the tablet disintegrates rapidly and releases the active ingredients. Effervescent tablets are easy to carry, disintegrate quickly when placed in water, and take effect quickly. [0003] Due to the presence of sodium bicarbonate and solid acid in the effervescent tablet, the tablet may react in h...
Claims
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Application Information
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