Phase-change composite microcapsule hydrogel and physical antipyretic patch thereof

A technology of composite microcapsules and hydrogels, which is applied in the direction of heating appliances for treatment, heat exchange materials, and cooling appliances for treatment, etc., to achieve high-efficiency cooling effects, good antipyretic efficiency, and improved antipyretic effect

Active Publication Date: 2016-06-15
SHANGHAI CHUANGSHI MEDICAL TECH (GRP) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the use of phase change microcapsules in antipyretic patches still needs to solve many problems such as the phase

Method used

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  • Phase-change composite microcapsule hydrogel and physical antipyretic patch thereof

Examples

Experimental program
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Example Embodiment

[0052] Example 1: Preparation of Red Pediatric Antipyretic Patch

[0053] (1) Preparation of phase change composite microcapsules: 14g of methyl stearate, 14g of eicosane, 12g of eicosane, 14g of styrene, 3g of divinylbenzene, 2g of acrylamide, Acrylic 1g, with 4g surface-treated Al 2 O 3 Stir and mix evenly to form oil phase A at 40°C. Stir 0.5 g of emulsifier sodium lauryl sulfate and 300 g of deionized water in a reactor to form water phase B, and heat in a water bath for 10 minutes to activate the emulsifier. The oil phase A was added to the water phase B, stirred and emulsified in a water bath at 45° C. at 2000 rpm for 15 min, and then ultrasonically dispersed in an ice water bath for 15 min to obtain a monomer mixed fine emulsion. Pour the fine emulsion into a three-neck reactor equipped with a stirrer and condenser, stir and pass N 2 , The temperature was raised to 70°C, 0.7g potassium persulfate KSP was added under slow stirring (200rpm) to start the polymerization react...

Example Embodiment

[0058] Example 2: Preparation of Yellow Pediatric Antipyretic Patch

[0059] (1) Preparation of phase change composite microcapsules: 14g methyl stearate, 14g eicosan, 12g eicosane, 14g styrene, 3g divinylbenzene, 2g acrylamide, 1g acrylic acid and 4g surface treatment Al 2 O 3 Stir and mix evenly to form oil phase A at 40°C. Stir 0.5 g of emulsifier sodium lauryl sulfate and 300 g of deionized water in a reactor to form water phase B, and heat in a water bath for 10 minutes to activate the emulsifier. The oil phase A was added to the water phase B, stirred and emulsified in a water bath at 45° C. at 2000 rpm for 15 min, and then ultrasonically dispersed in an ice water bath for 15 min to obtain a monomer mixed fine emulsion. Pour the fine emulsion into a three-neck reactor equipped with a stirrer and condenser, stir and pass N 2 , The temperature was raised to 70°C, 0.7g potassium persulfate KSP was added under slow stirring (200rpm) to start the polymerization reaction, and th...

Example Embodiment

[0064] Example 3: Preparation of blue pediatric antipyretic patch

[0065] (1) Preparation of phase change composite microcapsules: 14g methyl stearate, 14g eicosan, 12g eicosane, 14g styrene, 3g divinylbenzene, 2g acrylamide, 1g acrylic acid and 4g surface treatment Al 2 O 3 Stir and mix evenly to form oil phase A at 40°C. Stir 0.5 g of emulsifier sodium lauryl sulfate and 300 g of deionized water in a reactor to form water phase B, and heat in a water bath for 10 minutes to activate the emulsifier. The oil phase A was added to the water phase B, stirred and emulsified in a water bath at 45° C. at 2000 rpm for 15 min, and then ultrasonically dispersed in an ice water bath for 15 min to obtain a monomer mixed fine emulsion. Pour the fine emulsion into a three-neck reactor equipped with a stirrer and condenser, stir and pass N 2 , The temperature was raised to 70°C, 0.7g potassium persulfate KSP was added under slow stirring (200rpm) to start the polymerization reaction, and the ...

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Abstract

The invention discloses a phase-change composite microcapsule hydrogel and a physical antipyretic patch thereof; the phase-change composite microcapsule hydrogel contains a macromolecular substance, phase-change composite microcapsules, thermochromic microcapsules and other materials. The antipyretic patch is composed of a back lining layer, a hydrogel layer and an anti-sticking layer successively; the hydrogel is a phase-change composite microcapsule hydrogel and coats the back lining layer; the back lining layer is made of a pharmaceutical-graded non-woven fabric and is printed with a color-temperature correlation band, and the middle of the back lining layer is left with a gap for observation of color change of the hydrogel layer. The thermochromic microcapsules in the antipyretic patch can be gradually faded along with body temperature rising and is faded to be colorless when the temperature is higher than 39.5 DEG C, to warn that the antipyretic patch is failed. The phase-change composite microcapsule material of the antipyretic patch can be turned back to a solid after being cooled, can be used repeatedly, thereby saving cost. The phase-change material and the temperature-sensitive color changing material adopted by the antipyretic patch are both macromolecular materials, and the antipyretic patch is non-toxic and harmless, has no side effect and is safe to use.

Description

technical field [0001] The invention relates to the technical field of medical polymer materials, and specifically belongs to a phase-change composite microcapsule hydrogel and a physical antipyretic patch that integrates physical heat absorption and cooling, and temperature indication. Background technique [0002] Fever in children is a common and frequently occurring disease. If it is not treated in time, when the body temperature exceeds 41°C, the protein in the body will decompose, causing varying degrees of damage to the brain. Most of the existing cooling and antipyretic drugs are oral drugs, and have side effects, which are not conducive to children's use. Physical cooling is simple, reliable, and has few side effects. It is one of the effective measures to reduce fever and prevent convulsions and sequelae in children. It has been advocated by pediatric experts in recent years. Antipyretic plaster is a kind of external plaster that has become popular recently. It be...

Claims

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Application Information

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IPC IPC(8): C09K5/06A61F7/02
CPCA61F7/02A61F2007/0219C09K5/066
Inventor 刘付永焦媛马学文梁文婷周叶红王丽董川
Owner SHANGHAI CHUANGSHI MEDICAL TECH (GRP) CO LTD
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