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Phase-change composite microcapsule hydrogel and physical antipyretic patch thereof

A technology of composite microcapsules and hydrogels, which is applied in the direction of heating appliances for treatment, heat exchange materials, and cooling appliances for treatment, etc., to achieve high-efficiency cooling effects, good antipyretic efficiency, and improved antipyretic effect

Active Publication Date: 2016-06-15
SHANGHAI CHUANGSHI MEDICAL TECH (GRP) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the use of phase change microcapsules in antipyretic patches still needs to solve many problems such as the phase transition temperature of the materials used, heat transfer efficiency, compatibility between microcapsules and gels, etc.

Method used

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  • Phase-change composite microcapsule hydrogel and physical antipyretic patch thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] Example 1: Preparation of Red Children's Antipyretic Patch

[0053] (1) Preparation of phase change composite microcapsules: 14 g of methyl stearate, 14 g of eicosane, and 12 g of eicosane, 14 g of styrene, 3 g of divinylbenzene, 2 g of acrylamide, Acrylic acid 1g, with 4g surface treated Al 2 o 3 Stir at 40°C to evenly mix to form oil phase A. Stir 0.5 g of emulsifier sodium lauryl sulfate and 300 g of deionized water in a reactor to make water phase B, and heat in a water bath for 10 minutes to activate the emulsifier. Add the oil phase A to the water phase B, stir and emulsify in a 45°C water bath at a speed of 2000rpm for 15 minutes, and then ultrasonically disperse in an ice-water bath for 15 minutes to obtain a monomer mixed miniemulsion. Pour the fine emulsion into a three-port reactor equipped with a stirrer and a condenser tube, stir and feed N 2 , the temperature was raised to 70°C, and 0.7g potassium persulfate KSP was added under slow stirring (200rpm) t...

Embodiment 2

[0058] Example 2: Preparation of yellow antipyretic plaster for children

[0059] (1) Preparation of phase change composite microcapsules: 14g methyl stearate, 14g eicosane, 12g eicosane, 14g styrene, 3g divinylbenzene, 2g acrylamide, 1g acrylic acid and 4g surface treatment Al 2 o 3 Stir at 40°C to evenly mix to form oil phase A. Stir 0.5 g of emulsifier sodium lauryl sulfate and 300 g of deionized water in a reactor to make water phase B, and heat in a water bath for 10 minutes to activate the emulsifier. Add the oil phase A to the water phase B, stir and emulsify in a 45°C water bath at a speed of 2000rpm for 15 minutes, and then ultrasonically disperse in an ice-water bath for 15 minutes to obtain a monomer mixed miniemulsion. Pour the fine emulsion into a three-port reactor equipped with a stirrer and a condenser tube, stir and feed N 2 , the temperature was raised to 70°C, and 0.7g potassium persulfate KSP was added under slow stirring (200rpm) to start the polymeriz...

Embodiment 3

[0064]Example 3: Preparation of blue children's antipyretic patch

[0065] (1) Preparation of phase change composite microcapsules: 14g methyl stearate, 14g eicosane, 12g eicosane, 14g styrene, 3g divinylbenzene, 2g acrylamide, 1g acrylic acid and 4g surface treatment Al 2 o 3 Stir at 40°C to evenly mix to form oil phase A. Stir 0.5 g of emulsifier sodium lauryl sulfate and 300 g of deionized water in a reactor to make water phase B, and heat in a water bath for 10 minutes to activate the emulsifier. Add the oil phase A to the water phase B, stir and emulsify in a 45°C water bath at a speed of 2000rpm for 15 minutes, and then ultrasonically disperse in an ice-water bath for 15 minutes to obtain a monomer mixed miniemulsion. Pour the fine emulsion into a three-port reactor equipped with a stirrer and a condenser tube, stir and feed N 2 , the temperature was raised to 70°C, and 0.7g potassium persulfate KSP was added under slow stirring (200rpm) to start the polymerization r...

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Abstract

The invention discloses a phase-change composite microcapsule hydrogel and a physical antipyretic patch thereof; the phase-change composite microcapsule hydrogel contains a macromolecular substance, phase-change composite microcapsules, thermochromic microcapsules and other materials. The antipyretic patch is composed of a back lining layer, a hydrogel layer and an anti-sticking layer successively; the hydrogel is a phase-change composite microcapsule hydrogel and coats the back lining layer; the back lining layer is made of a pharmaceutical-graded non-woven fabric and is printed with a color-temperature correlation band, and the middle of the back lining layer is left with a gap for observation of color change of the hydrogel layer. The thermochromic microcapsules in the antipyretic patch can be gradually faded along with body temperature rising and is faded to be colorless when the temperature is higher than 39.5 DEG C, to warn that the antipyretic patch is failed. The phase-change composite microcapsule material of the antipyretic patch can be turned back to a solid after being cooled, can be used repeatedly, thereby saving cost. The phase-change material and the temperature-sensitive color changing material adopted by the antipyretic patch are both macromolecular materials, and the antipyretic patch is non-toxic and harmless, has no side effect and is safe to use.

Description

technical field [0001] The invention relates to the technical field of medical polymer materials, and specifically belongs to a phase-change composite microcapsule hydrogel and a physical antipyretic patch that integrates physical heat absorption and cooling, and temperature indication. Background technique [0002] Fever in children is a common and frequently occurring disease. If it is not treated in time, when the body temperature exceeds 41°C, the protein in the body will decompose, causing varying degrees of damage to the brain. Most of the existing cooling and antipyretic drugs are oral drugs, and have side effects, which are not conducive to children's use. Physical cooling is simple, reliable, and has few side effects. It is one of the effective measures to reduce fever and prevent convulsions and sequelae in children. It has been advocated by pediatric experts in recent years. Antipyretic plaster is a kind of external plaster that has become popular recently. It be...

Claims

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Application Information

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IPC IPC(8): C09K5/06A61F7/02
CPCA61F7/02A61F2007/0219C09K5/066
Inventor 刘付永焦媛马学文梁文婷周叶红王丽董川
Owner SHANGHAI CHUANGSHI MEDICAL TECH (GRP) CO LTD
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