A lung cancer risk prediction kit for high-risk urban population in China based on CT images and biomarker profiles

A technology of biomarkers and kits, applied in the field of medical biology, can solve the problems that the high-risk risk model of the Chinese population has not been reported, and achieve the effect of simple expression level

Active Publication Date: 2018-11-09
上海超联智医学科技中心(有限合伙)
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, lung cancer risk prediction models for European and American populations have been invented internationally, but high-risk risk models for Chinese populations have not been reported

Method used

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  • A lung cancer risk prediction kit for high-risk urban population in China based on CT images and biomarker profiles
  • A lung cancer risk prediction kit for high-risk urban population in China based on CT images and biomarker profiles

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Effect test

Embodiment 1

[0032] The composition of kit of the present invention:

[0033] Composed of biomarkers and their enzyme-labeled antibodies, carbonate buffer solution with a pH value of 9.6, phosphate buffer solution with a pH value of 7.4, serum protein dilution, stop solution, tetramethylbenzidine substrate solution, and normal people Serum and positive control serum composition.

[0034] The biomarkers include gastrin-releasing propeptide, carcinoembryonic antigen, cytokeratin 19 fragments and squamous cell carcinoma antigen; Add 2.93 grams of sodium bicarbonate to 1L of distilled water and obtain; the phosphate buffer solution with a pH value of 7.4 is 0.2 grams of potassium dihydrogen phosphate, 2.9 grams of disodium hydrogen phosphate dodecahydrate, 8.0 grams of sodium chloride, 0.2 gram potassium chloride, 0.5mL Tween-20 was added to 1L distilled water and obtained; the serum protein dilution was 0.1 gram bovine serum, goat serum or rabbit serum protein added to 100mL phosphate buffer...

Embodiment 2

[0050] The present invention collects 454 patients of the urban population who have clinically determined to have high-risk factors for lung cancer, and finally diagnoses 285 cases of lung cancer through pathology, and samples the serum of 111 lung cancer patients through a randomized method; at the same time, in the serum bank of 169 non-lung cancer patients, The serum of 129 normal persons was sampled by random method. Chemiluminescent microparticle immunoassay was used to detect four biomarkers in serum, and clinical information such as age, smoking history, nodule diameter, spiculation, and gender were collected at the same time. The sensitivity and specificity of the obtained models are shown in Table 1. The ROC curve of the lung cancer risk prediction model for high-risk groups based on CT images and biomarker profiles is as follows: figure 1 shown.

[0051] Table 1 The effectiveness of the lung cancer risk prediction model based on CT images and biomarker profiles for...

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Abstract

The invention discloses a kit for predicating lung cancer risk for high-risk groups among the China urban population on the basis of CT (computed tomography) images and biomarker spectrums. The kit comprises a reagent for measuring the expression quantity of serum protein spectrums of the following four biomarkers including pro-gastrin-releasing peptides, carcino-embryonic antigens, fragments of cytokeratin 19 and squamous-cell carcinoma antigens. The kit can be used for accurately predicating the lung cancer risk in combination of CT imageology parameters including nodule diameters, spicule signs and positions and other clinical indexes including age, the smoking history, the history of malignant tumor and genders.

Description

technical field [0001] The invention relates to the field of medical biotechnology, in particular to a lung cancer risk prediction kit for high-risk urban population in China based on CT images and biomarker spectrum. Background technique [0002] Lung cancer is the most common and deadly cancer worldwide. In my country, the morbidity and mortality of lung cancer rank first among all malignant tumors. According to the statistics of The International Agency for Research on Cancer (IARC) of the World Health Organization, the incidence of lung cancer in my country in 2008 was 35 per 100,000 people, and the agency estimated that by 2025, there will be 1 million new cases of lung cancer in my country every year . According to the 2010 Health Statistical Yearbook of the Ministry of Health of my country, as of 2009, the national lung cancer mortality rate was 30.83 / 100,000 people, which was higher than the second highest mortality rate of liver cancer by more than 4 / 100,000 people...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N23/046G01N33/68G01N33/574
CPCG01N23/04G01N33/57423G01N33/68
Inventor 白春学杨达伟周建
Owner 上海超联智医学科技中心(有限合伙)
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