Preparation method of choline fenofibrate acid sustained release capsule
A technology of fenofibric acid choline and sustained-release capsules, which is applied in the direction of non-active ingredient medical preparations, capsule delivery, microcapsules, etc., and can solve problems such as poor sustained-release effect and lack of fenofibric acid choline , to achieve the effect of fast and complete release
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[0017] The preparation method of fenofibric acid choline sustained-release capsules, the steps are as follows:
[0018] 1) Preparation of drug-loaded pellet core: Dissolve fenofibric acid choline with 3 times the weight of ethanol, add microcrystalline cellulose blank pellet core (purchased from JRS Pharmaceutical Excipient Company, Germany) into the fluidized bed, and add fenofibrate Spray the choline fenofibric acid ethanol solution onto the blank pellet core, control the atomization pressure at 2.5-3bar when applying the drug, the peristaltic pump speed at 100-120rpm, and the material temperature at 35-42°C. When the quality of fenofibric acid choline reaches When the mass of the blank ball core is 50%, stop applying the medicine and dry at 65°C for 2 hours;
[0019] 2) film coating: spray film coating agent on the drug-loaded ball core in fluidized bed, the raw material weight proportion of described film coating agent is ethyl cellulose 9%, dibutyl sebacate 1% , 45% etha...
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