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Preparation method of choline fenofibrate acid sustained release capsule

A technology of fenofibric acid choline and sustained-release capsules, which is applied in the direction of non-active ingredient medical preparations, capsule delivery, microcapsules, etc., and can solve problems such as poor sustained-release effect and lack of fenofibric acid choline , to achieve the effect of fast and complete release

Inactive Publication Date: 2016-07-13
WUHAN YAOGU BIOLOGICAL ENG
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  • Summary
  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

[0005] At present, there is a lack of sustained-release dosage forms of fenofibric acid choline, and existing sustained-release preparations have defects such as poor sustained-release effects

Method used

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  • Preparation method of choline fenofibrate acid sustained release capsule
  • Preparation method of choline fenofibrate acid sustained release capsule
  • Preparation method of choline fenofibrate acid sustained release capsule

Examples

Experimental program
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Embodiment 1

[0017] The preparation method of fenofibric acid choline sustained-release capsules, the steps are as follows:

[0018] 1) Preparation of drug-loaded pellet core: Dissolve fenofibric acid choline with 3 times the weight of ethanol, add microcrystalline cellulose blank pellet core (purchased from JRS Pharmaceutical Excipient Company, Germany) into the fluidized bed, and add fenofibrate Spray the choline fenofibric acid ethanol solution onto the blank pellet core, control the atomization pressure at 2.5-3bar when applying the drug, the peristaltic pump speed at 100-120rpm, and the material temperature at 35-42°C. When the quality of fenofibric acid choline reaches When the mass of the blank ball core is 50%, stop applying the medicine and dry at 65°C for 2 hours;

[0019] 2) film coating: spray film coating agent on the drug-loaded ball core in fluidized bed, the raw material weight proportion of described film coating agent is ethyl cellulose 9%, dibutyl sebacate 1% , 45% etha...

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Abstract

The invention discloses a preparation method of a choline fenofibrate acid sustained release capsule.The preparation method of the choline fenofibrate acid sustained release capsule comprises the process steps of drug-loaded core preparation, film-coating packaging, enteric coating packaging and the like.Compared with the similar products, the prepared choline fenofibrate acid sustained release capsule is higher in releasing speed and more complete in releasing.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a preparation method of fenofibric acid choline sustained-release capsules. Background technique [0002] The chemical name of fenofibric acid choline is 2-[4-(chlorobenzoyl)phenoxy]-2-methylpropionic acid choline salt, and its structural formula is as follows: [0003] [0004] The US FDA approved it to be used alone in patients with severe hypertriglyceridemia to reduce TG. It can also be used alone in patients with primary hyperlipidemia and mixed dyslipidemia to reduce elevated levels of LDL-C, total cholesterol, TG and apolipoprotein B and increase HDL-C levels. [0005] At present, there is a lack of sustained-release dosage forms of fenofibric acid choline, and the existing sustained-release preparations have defects such as poor sustained-release effects. Contents of the invention [0006] The purpose of the present invention is to provide a p...

Claims

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Application Information

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IPC IPC(8): A61K9/62A61K47/38A61K47/32A61K31/192A61P3/06
CPCA61K9/5078A61K9/0002A61K9/5026A61K9/5047A61K31/192
Inventor 熊富良张雪琼周利娟
Owner WUHAN YAOGU BIOLOGICAL ENG
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