Salts of phenylalanine compound and amorphous form of salts

A compound and amorphous technology, applied in the field of drugs for diseases, salts of phenylalanine compounds, and amorphous forms, can solve problems affecting drug safety and effectiveness, low bioavailability, easy decomposition, etc. To achieve the effect of improving bioavailability
CN105801468AActive Publication Date: 2016-07-27SHENZHEN CHIPSCREEN BIOSCIENCES CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SHENZHEN CHIPSCREEN BIOSCIENCES CO LTD
Publication Date
2016-07-27

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Abstract

The invention discloses salts of a phenylalanine compound as shown in a general formula (I), and an amorphous form of the salts. In the general formula (I), M is as defined in the specification. The invention also discloses a preparation method and application for the above-mentioned salts. The salts can be applied in treatment of diseases associated with metabolic syndrome.
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Description

technical field

[0001] The invention belongs to the field of chemical pharmacy, in particular to a salt of a phenylalanine compound, more specifically to the amorphous form of the salt; the present invention also relates to a preparation method of the salt and its amorphous form and its Use in the preparation of medicines for preventing or treating diseases related to metabolic syndrome. Background technique

[0002] 2-(2-(4-fluorobenzoyl)phenylamino)-3-(4-(2-(9H-carbazol-9-yl)ethoxy)phenyl)propanoic acid is a Diseases and disorders have therapeutic and prophylactic activity of phenylalanine compounds, the chemical structure of which is as follows:

[0003]

[0004] The pharmacological activity of this compound is described in Chinese patent application CN03126974.5 and US patent application US7,268,157. 2-(2-(4-fluorobenzoyl)phenylamino)-3-(4-(2-(9H-carbazol-9-yl)ethoxy)phenyl)propionic acid selectively activates PPAR -α, PPAR-γ and PPAR-δ capabilities can be used to ...

Claims

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