Environment-friendly method for preparing pyrano[2,3-d]pyrimidone derivate through catalysis

A catalytic preparation and environmentally friendly technology, applied in organic chemistry and other fields, can solve the problems of complex product purification process, difficult biodegradation, low utilization rate of raw materials, etc., and achieve convenient large-scale production, good biodegradability and high utilization rate Effect
CN105801587AActive Publication Date: 2016-07-27HOPE (NANJING) LIFE SCI INNOVATION INST CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
HOPE (NANJING) LIFE SCI INNOVATION INST CO LTD
Publication Date
2016-07-27

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Abstract

The invention discloses an environment-friendly method for preparing pyrano[2,3-d]pyrimidone derivate through catalysis, and belongs to the technical field of ion liquid catalysis.In the preparation reaction, the mole ratio of aromatic aldehyde to barbituric acid to malononitrile is 1:1:1-1.4.The molar weight of an acidic ionic liquid catalyst is 3-5% that of adopted aromatic aldehyde, the volume dose of a 60% ethanol aqueous solution measured by milliliter is 7-9 times molar weight of aromatic aldehyde measured by millimole, backflow reaction time is 10-25 min, the product is cooled to reach room temperature after the reaction is finished, suction filtration is performed, and filter residue is washed with ethyl alcohol and subjected to vacuum drying to obtain the pyrano[2,3-d]pyrimidone derivate.Compared with a preparation method adopting other acidic ionic liquid catalysts, the method has the advantages that the catalyst is biodegradable, the raw material utilization rate is high, the catalysis ability is strong, and the whole preparation process is easy and convenient to operate, and industrial large-scale application is convenient.
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Description

technical field

[0001] The invention belongs to the technical field of ionic liquid catalysis, and in particular relates to an environment-friendly catalytic method for preparing pyrano[2,3-d]pyrimidinone derivatives. Background technique

[0002] Pyrimidinone derivatives are a class of compounds containing nitrogen heterocyclic structures with important application value. Because of their structural variability, they have a wide range of biological activities and are widely used in the fields of medicine and pesticides. In the field of medicine, they It can be used as antineoplastic drugs, analgesic drugs, fungicides, herbicides, insecticides, etc., and is one of the hot spots in the development and research of new drugs and new pesticides. In addition, with the in-depth research on this type of compounds, it is found that some heterocyclic fused pyrimidinone derivatives also have excellent biological activities, such as pyrano[2,3-d]pyrimidinone derivatives can be used as ...

Claims

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