Method for preparing high-elasticity high-absorbency hemostatic and bacteriostatic expansive sponge

A high-elasticity, sponge technology, applied in the field of polyvinyl acetalized expansion sponge in many fields, can solve the problems of reducing water absorption and softness of materials, increasing wound infection, uneven cells, etc., and achieves excellent biocompatibility Effects of sex and cell affinity, reduced interference with surgery, and good biocompatibility

Inactive Publication Date: 2016-08-03
北京市中杰瑞康科技发展有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chitosan (chitosans) is a natural polymer material with good biocompatibility, but the hemostatic sponge prepared only from chitosan is not ideal for large bleeding wounds
Gelatin sponge is prepared from gelatin extracted and purified from animal skin, and is used in surgery and first aid, but gelatin sponge has poor adhesion, is easy to fall off, and increases the possibility of wound infection
[0007] The following problems exist in the currently disclosed patents: starch and the like are used as foaming agents to prepare medical modified PVA fast liquid-absorbing sponges, but the residual foaming agent contacts the wound, which is likely to cause rejection of the matrix, foaming agent cleaning and pollution Problems also restrict its production and application; using sodium bicarbonate as a foaming agent, a highly water-absorbing foamed polyvinyl alcohol sponge is prepared, the product cells are not uniform, the size is different, the process is difficult to control, and the product yield is low; Alcohol and chitosan are used as raw materials, formaldehyde is used as a crosslinking agent, sulfuric acid is used as a catalyst, and a surfactant is used to prepare a polyvinyl formal sponge with antibacterial properties. Chitosan is introduced to reduce the water absorption and softness of the material , so that the composite material does not have the characteristics of rapid expansion when absorbing water
[0008] The present invention is based on the above needs, in order to overcome the defects of the above preparation methods, solve the low yield, qualitative change, and uneven bubbles caused by traditional production methods, and solve the problem that current medical sponges cannot meet actual needs, it is necessary to develop a sponge with high absorption capacity. Liquid, rapid swelling performance, good biocompatibility and soft texture swelling sponge, and make it have hemostatic and antibacterial ability

Method used

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  • Method for preparing high-elasticity high-absorbency hemostatic and bacteriostatic expansive sponge
  • Method for preparing high-elasticity high-absorbency hemostatic and bacteriostatic expansive sponge
  • Method for preparing high-elasticity high-absorbency hemostatic and bacteriostatic expansive sponge

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] Step 1: remove a certain amount of PVA, and add a certain amount of deionized water according to the requirement that the mass ratio of PVA to deionized water is 1:5. Heat and stir in a water bath at 95°C for 1 hour to fully dissolve the PVA particles. Adjust the temperature of the constant temperature water bath to 60°C, weigh the sodium alginate according to the mass ratio of polyvinyl alcohol to sodium alginate as 1:0.2, add it to the above polyvinyl alcohol solution, continue to stir until the sodium alginate dissolves evenly, and let stand 0.5h, remove air bubbles and keep warm.

[0055] Step 2: Add the mixed solution of surfactant and catalyst to the mixed solution of polyvinyl alcohol sodium alginate, and stir at a low speed for 2 to 5 minutes, so that the surfactant and catalyst can be uniformly dispersed in the solution, so that the surfactant and catalyst can be uniformly dispersed. dispersed into the solution.

[0056] Step 3: Weigh the formaldehyde solutio...

Embodiment 2

[0060] Step 1. Remove a certain amount of PVA, and add a certain amount of deionized water according to the requirement that the mass ratio of PVA to deionized water is 1:7. Heat and stir in a water bath at 95°C for 1 hour to fully dissolve the PVA particles. Adjust the temperature of the constant temperature water bath to 60°C, weigh the sodium alginate according to the mass ratio of polyvinyl alcohol to sodium alginate as 1:0.6, add it to the above polyvinyl alcohol solution, continue to stir until the sodium alginate dissolves evenly, and let stand 0.5h, remove air bubbles and keep warm.

[0061] Step 2: Add the mixed solution of surfactant and catalyst into the mixed solution of polyvinyl alcohol sodium alginate, and stir at a low speed for 2-5 minutes, so that the surfactant and catalyst can be uniformly dispersed in the solution.

[0062] Step 3. Weigh the glutaraldehyde solution according to the mass ratio of polyvinyl alcohol and glutaraldehyde solution as 1:1.5, add ...

Embodiment 3

[0065] Step 1: remove a certain amount of PVA, and add a certain amount of deionized water according to the requirement that the mass ratio of PVA to deionized water is 1:8. Heat and stir in a water bath at 95°C for 1 hour to fully dissolve the PVA particles. Adjust the temperature of the constant temperature water bath to 60°C, weigh the sodium alginate according to the mass ratio of polyvinyl alcohol to sodium alginate as 1:1, add it to the above polyvinyl alcohol solution, continue to stir until the sodium alginate dissolves evenly, and let stand 0.5h, remove air bubbles and keep warm.

[0066] Step 2: Add the mixed solution of surfactant and catalyst into the mixed solution of polyvinyl alcohol sodium alginate, and stir at a low speed for 2-5 minutes, so that the surfactant and catalyst can be uniformly dispersed in the solution.

[0067] Step 3: Weigh the fatty aldehyde solution according to the mass ratio of polyvinyl alcohol and fatty aldehyde to 1:1, add it into the m...

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Abstract

The invention discloses a highly elastic and highly liquid-absorbing hemostatic and antibacterial expansion sponge and a preparation method thereof, which belong to the field of medical materials. In the present invention, polyvinyl alcohol is stirred in deionized water to form a solution, and surfactant and sodium alginate are added to the solution, and the sodium alginate is mixed evenly by stirring, then catalyst, cross-linking agent and bacteriostat are added, and high-speed stirring Then pour into the mold for cross-linking reaction. Put the mold into an oven for molding, and then soak the sample in the antibacterial agent solution or sol to make a sodium alginate composite polyvinyl acetalized expansion sponge; or add silver to the polyvinyl alcohol sodium alginate mixed solution Ammonia solution, and then generate silver through silver mirror reaction, and synthesize sodium alginate-nano-silver composite polyvinyl acetalization expansion sponge. The invention is light in weight, small in thermal conductivity, good in biocompatibility, fast in dry state wetting rate, high in strength, high in liquid absorption rate and expansion rate, and can be used as medical hemostasis, antibacterial dressing and orthopedic or nasal surgery filling material.

Description

technical field [0001] The present invention relates to a polyvinyl acetalized expansion sponge used in many fields such as medical hemostasis, biological antibacterial, rapid wound healing, bone filling, nasal cavity, gum and other surgical fillings, especially relates to a kind of good biocompatibility, A polyvinyl acetalized swelling sponge with fast liquid absorption rate and fast liquid absorption expansion rate, a medical carrier, antibacterial, and reduced wound infection rate, and a preparation method thereof. Background technique [0002] Polyvinyl acetal sponges, especially polyvinyl acetalized sponges with a foaming structure within a certain range of acetalization, have super strong liquid absorption capacity, and their liquid absorption times can reach several times their own weight. Dozens of times. In addition, it has a high liquid absorption rate, good wet elasticity after absorbing liquid, and fast drying speed, so it is widely used in the medical field. Co...

Claims

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Application Information

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IPC IPC(8): A61L26/00C08J9/40C08J3/24C08L29/04C08L5/04
CPCC08J9/40A61L26/0019A61L26/0023A61L26/0066A61L26/0085A61L2300/104A61L2300/404C08J3/24C08J2305/04C08J2329/04C08J2405/04C08J2429/04C08L29/04C08L5/04
Inventor 郑裕东王岩森
Owner 北京市中杰瑞康科技发展有限责任公司
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