Preparation method for ambroxol hydrochloride capsule
A technology of ambroxol hydrochloride and capsules, which is applied in the field of preparation of ambroxol hydrochloride capsules, can solve problems such as uneven capsule quality, poor capsule drug stability, and affecting the stability of raw materials, achieving good stability and fewer types of raw materials , low cost effect
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Example Embodiment
[0021] Example 1
[0022] This embodiment provides a method for preparing ambroxol hydrochloride capsules, including the following steps:
[0023] S1: Weigh 700g ambroxol hydrochloride, 100g microcrystalline cellulose, 1000g pregelatinized starch, 200g gelatin, 100g talcum powder and 350g magnesium stearate according to the ratio;
[0024] S2: Put the above-mentioned raw materials into the grinder in turn, grind for 20-30 minutes, take out the 100-mesh sieve, weigh, and set aside;
[0025] S3: Take a stirred tank, add ambroxol hydrochloride, microcrystalline cellulose, pregelatinized starch, gelatin and talc into the stirred tank, adjust the speed to 600-900 rpm, and mix for 5-10 minutes to obtain a mixture ;
[0026] S4: Dry the mixture into granules, and pass through a 30-mesh sieve to obtain granules;
[0027] S5: Blend the granules with magnesium stearate and mix them uniformly to obtain a filling; fill the filling into a capsule to form ambroxol hydrochloride capsules.
Example Embodiment
[0028] Example 2
[0029] This embodiment provides a method for preparing ambroxol hydrochloride capsules, including the following steps:
[0030] S1: Weigh 625g ambroxol hydrochloride, 300g microcrystalline cellulose, 1500g pregelatinized starch, 500g gelatin, 200g talcum powder and 312g magnesium stearate in proportion;
[0031] S2: Put the above-mentioned raw materials into the grinder in turn, grind for 20-30 minutes, take out the 100-mesh sieve, weigh, and set aside;
[0032] S3: Take a stirred tank, add ambroxol hydrochloride, microcrystalline cellulose, pregelatinized starch, gelatin and talc into the stirred tank, adjust the speed to 600-900 rpm, and mix for 5-10 minutes to obtain a mixture ;
[0033] S4: Dry the mixture into granules, and pass through a 30-mesh sieve to obtain granules;
[0034] S5: Blend the granules with magnesium stearate and mix them uniformly to obtain a filling; fill the filling into a capsule to form ambroxol hydrochloride capsules.
Example Embodiment
[0035] Example 3
[0036] This embodiment provides a method for preparing ambroxol hydrochloride capsules, including the following steps:
[0037] S1: Weigh 600g ambroxol hydrochloride, 500g microcrystalline cellulose, 2000g pregelatinized starch, 800g gelatin, 300g talcum powder and 300g magnesium stearate according to the ratio;
[0038] S2: Put the above-mentioned raw materials into the grinder in turn, grind for 20-30 minutes, take out the 100-mesh sieve, weigh, and set aside;
[0039] S3: Take a stirred tank, add ambroxol hydrochloride, microcrystalline cellulose, pregelatinized starch, gelatin and talc into the stirred tank, adjust the speed to 600-900 rpm, and mix for 5-10 minutes to obtain a mixture ;
[0040] S4: Dry the mixture into granules, and pass through a 30-mesh sieve to obtain granules;
[0041] S5: Blend the granules with magnesium stearate and mix them uniformly to obtain a filling; fill the filling into a capsule to form ambroxol hydrochloride capsules.
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