DNA sequencing device and manufacturing method

A DNA sequencing and hexagonal boron nitride technology, applied in the field of DNA sequencing, can solve the problems of limiting the accuracy and reliability of nanopore DNA sequencing, and achieve the effect of improving the low signal-to-noise ratio

Inactive Publication Date: 2016-08-10
BEIJING JIAOTONG UNIV
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Problems solved by technology

Since the above two types of methods have different requirements on the structure of nanopores, they are often used separately, which limits the accuracy and reliability of nanopore DNA sequencing.

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  • DNA sequencing device and manufacturing method
  • DNA sequencing device and manufacturing method
  • DNA sequencing device and manufacturing method

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Embodiment Construction

[0039] The embodiments of the present invention are described in detail below. Examples of the embodiments are shown in the accompanying drawings, wherein the same or similar reference numerals indicate the same or similar elements or elements with the same or similar functions. The following embodiments described with reference to the accompanying drawings are exemplary, and are only used to explain the present invention, and cannot be construed as limiting the present invention.

[0040] Those skilled in the art can understand that, unless specifically stated otherwise, the singular forms "a", "an", "said" and "the" used herein may also include plural forms. It should be further understood that the term "comprising" used in the specification of the present invention refers to the presence of the described features, integers, steps, operations, elements and / or components, but does not exclude the presence or addition of one or more other features, Integers, steps, operations, el...

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Abstract

The invention provides a DNA sequencing device and a manufacturing method. The device mainly comprises a silicon dioxide thin film arranged on a double-side polished monocrystalline silicon piece. A silicon nitride thin film grows on the top of the silicon dioxide thin film. A bottom layer contact electrode is prepared on the silicon nitride thin film and covered with a bottom layer graphene micro-strip. The bottom layer graphene micro-strip is covered with a hexagonal boron nitride micro-strip. The hexagonal boron nitride micro-strip is covered with a top layer graphene micro-strip. A graphene-hexagonal boron nitride-graphene heterostructure is formed by the bottom layer graphene micro-strip, the hexagonal boron nitride micro-strip and the top layer graphene micro-strip. Graphene-hexagonal boron nitride-graphene nano-pores are etched. According to the device, the problem that a conventional solid-state nano-pore channel is too long, so that the sequencing resolution ratio does not reach single base is solved, and the problem that a tunneling electrode is difficult to manufacture in a tunneling current DNA sequencing method is solved. The advantages lay a foundation for achieving single base resolution ratio and direct nano-pore sequencing.

Description

Technical field [0001] The invention relates to the technical field of DNA sequencing, in particular to a DNA sequencing device and a manufacturing method. Background technique [0002] Deoxyribonucleic acid (DNA) sequencing technology is one of the core technologies of modern life science research. From the first-generation sequencing technology based on the fluorescent-labeled Sanger method to the second-generation sequencing technology represented by the cyclic array synthesis sequencing method, it has greatly changed the way people study all life blueprints and promoted the creation of genomics and related disciplines. And development. [0003] However, after decades of development, the first-generation sequencing technology has reached its limit in terms of speed and cost due to its dependence on electrophoretic separation technology. The second-generation sequencing technology relies on fluorescent or chemiluminescent substances, making it difficult to significantly reduce ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12M1/34C12Q1/68
CPCC12Q1/6869C12Q2565/607C12Q2565/631
Inventor 邓涛刘亚轩侯建军
Owner BEIJING JIAOTONG UNIV
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