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A kind of animal vaccine oil adjuvant and animal vaccine thereof

An oil adjuvant and vaccine technology, which can be used in drug combinations, antiviral agents, allergic diseases, etc., can solve problems such as unsatisfactory immune effects, animal side reactions, and difficulty in vaccine injection, and achieve easy product process quality control. The effect of the application foreground

Active Publication Date: 2019-06-07
CHINA ANIMAL HUSBANDRY IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Traditional adjuvants often use Span Twain as emulsifier and stearic acid as thickener, which makes the adjuvant system viscous, making vaccine injection difficult, and may cause tissue inflammatory reactions after injection, which will cause side effects in animals. Unsatisfactory effect

Method used

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  • A kind of animal vaccine oil adjuvant and animal vaccine thereof
  • A kind of animal vaccine oil adjuvant and animal vaccine thereof
  • A kind of animal vaccine oil adjuvant and animal vaccine thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] The animal vaccine oil adjuvant described in this embodiment is composed as follows by weight percentage:

[0060] mineral oil for injection

[0061] MARCOL 52 60%

[0062] Emulsifier A

[0063] Span 80 (Sorbitan Monooleate) 7%

[0064] Emulsifier B

[0065] Tween 85 (polyoxyethylene sorbitan trioleate) 3%

[0066] Emulsifier C

[0067] Alkyl Glucoside (Decyl Glucoside) (APG0816) 25%

[0068] co-emulsifier

[0069] Macrogol 400 5%

Embodiment 2

[0071] The animal vaccine oil adjuvant described in this embodiment is composed as follows by weight percentage:

[0072] mineral oil for injection

[0073] Hangzhou Petrochemical Injection Grade White Oil 84%

[0074] Emulsifier B

[0075] Tween 80 (polyoxyethylene sorbitan monooleate) 1.5%

[0076] Emulsifier C

[0077] Alkyl Glucoside (Coco Glucoside) (APG1216) 14%

[0078] co-emulsifier

[0079] Stearic Acid 0.5%.

Embodiment 3

[0081] The animal vaccine oil adjuvant described in this embodiment is composed as follows by weight percentage:

[0082] mineral oil for injection

[0083] MARCOL 52 95%

[0084] Emulsifier A

[0085] Span 85 (Sorbitan Trioleate) 0.5%

[0086] Emulsifier C

[0087] Alkyl Glucoside (Coco Glucoside) (APG0814) 4%

[0088] co-emulsifier

[0089] Triglycerin 0.5%

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Abstract

The invention relates provides a stable and efficient oil animal vaccine adjuvant, which comprises the following components by weight: 60-95 parts of injection mineral oil, 0-25 parts of an emulsifier A, 0-25 parts of an emulsifier B, 0.5-25 parts of an emulsifier C and 0-5 parts of a co-emulsifier. The oil animal vaccine adjuvant has fine and uniform vaccine particle size after emulsification and can achieve good immunity effect. An animal vaccine prepared by the special oil animal vaccine adjuvant has the advantage of safety and efficiency.

Description

technical field [0001] The invention relates to the field of vaccine adjuvants, and provides a high-efficiency adjuvant suitable for animal vaccines and animal vaccines thereof. Background technique [0002] An adjuvant refers to a substance that can be applied simultaneously or in advance with an antigen to enhance the body's immune response to the antigen, or to change the type of immune response. Adjuvants play a vital role in vaccines. They can act on both antigens and the body. Appropriate use of adjuvants can regulate or even change the type of antigen-specific humoral and / or cellular immune responses produced by the body's immune system. In 1925, Ramon, a French veterinary immunologist, first observed that adding some irrelevant substances to the vaccine could specifically enhance the body's immune response. In 1926, Glenny was the first to use aluminum compounds as immune adjuvants in diphtheria exotoxin vaccines. [0003] The mechanism of action of immune adjuvant...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K39/39A61P37/04A61P31/12
Inventor 潘京学潘春刚王贺民黄文强彭正啟马爱荣
Owner CHINA ANIMAL HUSBANDRY IND