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Device and method for rapidly detecting sevoflurane online

A sevoflurane, rapid technology, applied in the field of analytical chemistry analysis, can solve the problems of expensive instruments, inconvenient online real-time monitoring, high detection cost, etc., and achieve the effect of simple structure, low cost and easy miniaturization

Active Publication Date: 2016-08-24
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method requires a relatively complicated sample pretreatment process, the required instruments are expensive, the detection cost is high, and strict experimental conditions are required. Most importantly, this method is not convenient for online real-time monitoring

Method used

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  • Device and method for rapidly detecting sevoflurane online
  • Device and method for rapidly detecting sevoflurane online
  • Device and method for rapidly detecting sevoflurane online

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] In this embodiment, the device for rapid on-line detection of sevoflurane is used to determine the optimal detection wavelength, heating temperature, etc. for the method of on-line rapid detection of sevoflurane.

[0046] 1) Determine the best detection wavelength

[0047] Select filters with wavelengths of 400nm, 425nm, 440nm, 460nm, 490nm, 535nm, 555nm, 575nm, and 620nm as spectrometers 5 to detect sevoflurane luminescence signals and signal-to-noise ratios of filters with different wavelengths. Taking the filter plate of 440nm wavelength as the beam splitter 5 as an example, the specific steps are as follows,

[0048] (1) Heat the heating element 9 sintered with nanometer strontium oxide 8 on the surface through the temperature controller 4, and control its surface temperature to be fixed at a certain temperature between 120-268°C.

[0049] (2) Configure sevoflurane standard gas with a concentration of 60 μmoL / L, and use a dual-channel air pump 2 to pass sevoflurane...

Embodiment 2

[0071] see figure 1 , applying the online rapid detection device and method of the present invention to real-time online monitoring of sevoflurane content in exhaled breath. In this embodiment, rabbits are used as the experimental subject 10 .

[0072] (1) Heat the heating element 9 with nano-strontium oxide 8 sintered on the surface through the temperature controller 4, and control its surface temperature to be fixed at 210° C.;

[0073] (2) After using sevoflurane to anesthetize the subject 10 rabbits, put the sampling head 1 around the face of the subject 10, start the dual-channel air pump 2 to pass the exhaled air of the subject 10 into the chemiluminescent reaction at a flow rate of 400mL / min The real-time on-line catalysis of sevoflurane concentration in the exhaled gas is carried out in the chamber 3; the light to be detected with a wavelength of 440nm is obtained through the spectrometer 5, and the luminescent signal at 440nm is recorded by the detector 6;

[0074] ...

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Abstract

The invention discloses a device and a method for rapidly detecting sevoflurane online. The device comprises a sampling unit and a cataluminescence sensing unit, wherein the sampling unit comprises a sampling head and a double-channel air pump, the sampling head is connected with an air inlet of a first channel of the double-channel air pump, and an air inlet of a second channel of the double-channel air pump is communicated with air; the cataluminescence sensing unit comprises a chemiluminescence reaction chamber, a temperature controller, an optical splitter and a detector; a heating element is arranged in the chemiluminescence reaction chamber, and nanometer strontium oxide is sintered on the surface of the heating element; the temperature controller is electrically connected with the heating element, and the optical splitter is arranged between the chemiluminescence reaction chamber and the detector, so that light emitted from the chemiluminescence reaction chamber passes through the optical splitter and then is received and detected by the detector. According to the device and the method, nanometer strontium oxide is adopted as a sensor element, has good selectivity for sevoflurane and can be directly used for rapidly analyzing sevoflurane in complex samples.

Description

technical field [0001] The invention relates to the technical field of analytical chemistry analysis, in particular to an on-line rapid detection device and method for sevoflurane, which is suitable for on-line rapid detection of sevoflurane in complex samples such as environmental samples and exhaled gas samples. Background technique [0002] Sevoflurane is an inhaled anesthetic that enters the body through lung ventilation and then is excreted through exhalation. It is generally suitable for the induction and maintenance of general anesthesia clinically. Sevoflurane is widely used because of its convenient medication, good anesthesia effect, almost no stimulation to the exhalation tract, greatly shortened induction time, short recovery period, and less liver damage compared with isoflurane and halothane. in modern anesthesiology. Sevoflurane changes the depth of anesthesia by inhibiting the reticular neurons in the midbrain in a concentration-dependent manner. In other wo...

Claims

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Application Information

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IPC IPC(8): G01N21/76
CPCG01N21/76
Inventor 李攻科张润坤胡玉斐黄婉婷
Owner SUN YAT SEN UNIV
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