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Extraction process of emodin

An extraction process, emodin technology, applied in the direction of organic chemistry, quinone separation/purification, etc., can solve the problems of high price, environmental pollution, harsh extraction conditions, etc., and achieve the effect of high extraction rate and good purity

Inactive Publication Date: 2016-08-31
SUZHOU TIANLING CHINESE TRADITIONAL MEDICINE SLICE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Existing extraction methods for extracting emodin mainly include: one, extracting from rhubarb or knotweed with organic solvents such as benzene, pyridine, ethanol, ethers, which is not only expensive but also causes environmental pollution; two, enzymolysis and extraction with cellulase , the extraction conditions are relatively harsh, and the large-scale extraction investment is relatively large

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] A kind of extraction technology of emodin, comprises the following steps:

[0019] Step 1, take rhubarb, wash it, dry it at 110°C, and pulverize it to obtain a fine powder;

[0020] Step 2, distilling the fine powder obtained in step 1 by steam distillation to remove the distilled impurities to obtain a refined powder;

[0021] Step 3, in parts by weight, take 30 parts of the refined powder obtained in step 2 and add it to 150 parts of ethanol aqueous solution, heat and reflux for extraction, let it cool, adjust the pH of the extract to 3.0, let it stand for stratification, and send the supernatant to microfiltration membrane to obtain microfiltration permeate;

[0022] Step 4, heating and concentrating the microfiltration permeate obtained in step 3 to obtain a concentrated solution;

[0023] In step 5, the concentrated solution obtained in step 4 is sent to a chromatographic column for impurity removal, and the obtained permeate is spray-dried to obtain emodin.

[...

Embodiment 2

[0027] A kind of extraction technology of emodin, comprises the following steps:

[0028] Step 1, take rhubarb, wash it, dry it at 115°C, and pulverize it to obtain a fine powder;

[0029] Step 2, distilling the fine powder obtained in step 1 by steam distillation to remove the distilled impurities to obtain a refined powder;

[0030] Step 3, in parts by weight, take 35 parts of the refined powder obtained in step 2 and add it to 180 parts of ethanol aqueous solution, heat and reflux for extraction, after letting it cool, adjust the pH of the extract to 3.5, let it stand for stratification, and send the supernatant to microfiltration membrane to obtain microfiltration permeate;

[0031] Step 4, heating and concentrating the microfiltration permeate obtained in step 3 to obtain a concentrated solution;

[0032] In step 5, the concentrated solution obtained in step 4 is sent to a chromatographic column for impurity removal, and the obtained permeate is spray-dried to obtain em...

Embodiment 3

[0036] A kind of extraction technology of emodin, comprises the following steps:

[0037] Step 1, take rhubarb, wash it, dry it at 120°C, and pulverize it to obtain a fine powder;

[0038] Step 2, distilling the fine powder obtained in step 1 by steam distillation to remove the distilled impurities to obtain a refined powder;

[0039] Step 3, in parts by weight, take 30 parts of the refined powder obtained in step 2 and add it to 170 parts of ethanol aqueous solution, heat and reflux for extraction, let it cool, adjust the pH of the extract to 4.0, let it stand for stratification, and send the supernatant to microfiltration membrane to obtain microfiltration permeate;

[0040] Step 4, heating and concentrating the microfiltration permeate obtained in step 3 to obtain a concentrated solution;

[0041] In step 5, the concentrated solution obtained in step 4 is sent to a chromatographic column for impurity removal, and the obtained permeate is spray-dried to obtain emodin.

[...

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PUM

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Abstract

The invention provides an extraction process of emodin, comprising: taking Chinese rhubarb root, washing, drying at 110-130 DEG C, crushing to obtain fine powder, distilling the fine powder by steam distillation, removing distilled impurity, adding refined powder to ethanol solution, heating and refluxing for extracting, standing and cooling, adjusting pH of extract to 3.0-4.4, standing for layering, charging supernate into a microfiltration membrane for filtering, heating and concentrating micro filtrate, charging concentrate into a chromatographic column for cleaning, and spray drying obtained permeate to obtain emodin. The extraction process is higher in extraction efficiency, the obtained emodin is high in purity, capable of significantly decreasing serums TC, TG and LDL-C in rats with hyperlipidemia due to high-fat feed and increasing HDL-C, and has hypolipidemic effect.

Description

technical field [0001] The invention belongs to the technical field of natural products, and in particular relates to an extraction process of emodin. Background technique [0002] Rhubarb is a perennial herb with a plant height of 1 to 1.5 meters. The rhizome is thick and thick, so it is named for its yellow rhizome. What is usually called rhubarb is mainly the dried roots and rhizomes of rhubarb palmatum, rhubarb tangutica or medicinal rhubarb of the family Liaceae, which are widely distributed in mountainous grass slopes above 1 meter above sea level in Shaanxi, Hubei, Sichuan and Yunnan. place. Its active ingredients are emodin, chrysophanol, aloe-emodin, rhein, emodin methyl ether and their derivatives containing anthracene aldehydes. Rhubarb has a variety and two subspecies in my country. It is a famous specialty medicinal material and one of the commonly used clinical traditional Chinese medicines in my country. It has a long history of medicinal use and unique eff...

Claims

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Application Information

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IPC IPC(8): C07C46/10C07C50/34
CPCC07C46/10C07C50/34
Inventor 李建华
Owner SUZHOU TIANLING CHINESE TRADITIONAL MEDICINE SLICE
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