Efficient circulation extraction method for radix polygonati officinalis total flavones and purification method of radix polygonati officinalis total flavones

Abstract

The invention discloses an efficient circulation extraction method for radix polygonati officinalis total flavones and a purification method of the radix polygonati officinalis total flavones and relates to the technical field of biological pharmacy extracting and processing. The extraction method includes the following steps of 1, radix polygonati officinalis raw material pretreatment; 2, circulation extraction. The step of radix polygonati officinalis raw material treatment includes the procedures of drying; smashing; moisture absorbing; soaking. The step of circulation extraction includes the procedures of packing, primary extraction; secondary extraction; N extraction, wherein a primary radix polygonati officinalis flavone extracting solution, a secondary radix polygonati officinalis flavone extracting solution,... and an N radix polygonati officinalis flavone extracting solution which are collected are mixed to be uniform, and then a radix polygonati officinalis total flavone extracting solution is obtained. The purification method includes the following steps that 1, preparation of a purification solution; 2, resin feeding; 3, elution; 4, drying. The advantages that the use quantity of the extraction solvent is small, the requirements for production equipment and production conditions are low, the production cost is low, and multiple effective ingredients can be extracted at a time, and the extraction method and the purification method can be used for extracting and purifying the total flavones in radix polygonati officinalis and can be used for extracting and purifying the total flavones of plants such as ginkgo leaves, honeysuckle flowers and tea leaves.

Description

technical field [0001] The invention relates to the technical field of biopharmaceutical extraction and processing, in particular to a high-efficiency circulation extraction method and a purification method of Polygonatum Polygonatum total flavonoids. Background technique [0002] Polygonatum odoratum (Mill.) Druce, also known as tail ginseng, wilt soup, bell block dish, ground pipe, sweet grass root, is a perennial herb of the genus Polygonatum in the family Liliaceae. Polygonatum Polygonatum contains a variety of flavonoids. Modern pharmacological studies have shown that the total flavonoids of Polygonatum Polygonatum have obvious antioxidant effects in vivo and in vitro, and have pharmacological effects such as hypoglycemic, immune regulation, anti-oxidation, anti-aging, and anti-tumor. [0003] In the prior art, the extraction methods of Polygonatum Polygonatum total flavonoids mainly include reflux extraction and ultrasonic-assisted extraction. Although the extraction r...

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Problems solved by technology

[0003] In the prior art, the extraction methods of Polygonatum Polygonatum total flavonoids mainly include reflux extraction and ultrasonic-assisted extraction. Although the extraction rates of these two extraction methods are slightly higher, they generally have a higher feed-liquid ratio, reaching 1:(20-36 ), that is, the consumption of extraction solvent is large; at the same time, the extraction temperature needs to be controlled at 60-80°C, which requires high production conditions and equipment used for extraction

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