Efficient circulation extraction method for radix polygonati officinalis total flavones and purification method of radix polygonati officinalis total flavones

A technology of cyclic extraction and total flavonoids, which is applied in the direction of pharmaceutical formulas, medical preparations containing active ingredients, anti-toxins, etc., can solve the problems of large extraction solvent consumption, high material liquid, high equipment requirements, etc., and reduce fixed costs. , low condition requirements, and the effect of reducing equipment investment

Inactive Publication Date: 2016-09-21
HUNAN UNIV OF SCI & ENG +1
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Problems solved by technology

[0003] In the prior art, the extraction methods of Polygonatum Polygonatum total flavonoids mainly include reflux extraction and ultrasonic-assisted extraction. Although the extraction rates of these two extraction methods are slightly higher, they generally have

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  • Efficient circulation extraction method for radix polygonati officinalis total flavones and purification method of radix polygonati officinalis total flavones

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Embodiment Construction

[0055] Below in conjunction with embodiment, the present invention is described further. The following description is by way of example, but the protection scope of the present invention is not limited thereto.

[0056] In this embodiment, three stages of glass chromatography columns are used, and each stage uses three extractions. The extraction solvent is ethanol solution with a volume concentration of 40%, and the extraction condition is normal temperature.

[0057] Specifically, the high-efficiency circulation extraction and purification process of Polygonatum Polygonatum total flavonoids in this embodiment is as follows:

[0058] 1. Polygonatum odoratum raw material pretreatment:

[0059] (1) Drying: place the polygonatum polygonatum raw material for extraction in an oven, and dry it at 60°C until the moisture content is ≤1%, to obtain dried polygonatum polygonatum, which is set aside;

[0060] (2) Pulverization: pulverize the spare dry Polygonatum odoratum and pass th...

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Abstract

The invention discloses an efficient circulation extraction method for radix polygonati officinalis total flavones and a purification method of the radix polygonati officinalis total flavones and relates to the technical field of biological pharmacy extracting and processing. The extraction method includes the following steps of 1, radix polygonati officinalis raw material pretreatment; 2, circulation extraction. The step of radix polygonati officinalis raw material treatment includes the procedures of drying; smashing; moisture absorbing; soaking. The step of circulation extraction includes the procedures of packing, primary extraction; secondary extraction; N extraction, wherein a primary radix polygonati officinalis flavone extracting solution, a secondary radix polygonati officinalis flavone extracting solution,... and an N radix polygonati officinalis flavone extracting solution which are collected are mixed to be uniform, and then a radix polygonati officinalis total flavone extracting solution is obtained. The purification method includes the following steps that 1, preparation of a purification solution; 2, resin feeding; 3, elution; 4, drying. The advantages that the use quantity of the extraction solvent is small, the requirements for production equipment and production conditions are low, the production cost is low, and multiple effective ingredients can be extracted at a time, and the extraction method and the purification method can be used for extracting and purifying the total flavones in radix polygonati officinalis and can be used for extracting and purifying the total flavones of plants such as ginkgo leaves, honeysuckle flowers and tea leaves.

Description

technical field [0001] The invention relates to the technical field of biopharmaceutical extraction and processing, in particular to a high-efficiency circulation extraction method and a purification method of Polygonatum Polygonatum total flavonoids. Background technique [0002] Polygonatum odoratum (Mill.) Druce, also known as tail ginseng, wilt soup, bell block dish, ground pipe, sweet grass root, is a perennial herb of the genus Polygonatum in the family Liliaceae. Polygonatum Polygonatum contains a variety of flavonoids. Modern pharmacological studies have shown that the total flavonoids of Polygonatum Polygonatum have obvious antioxidant effects in vivo and in vitro, and have pharmacological effects such as hypoglycemic, immune regulation, anti-oxidation, anti-aging, and anti-tumor. [0003] In the prior art, the extraction methods of Polygonatum Polygonatum total flavonoids mainly include reflux extraction and ultrasonic-assisted extraction. Although the extraction r...

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Application Information

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IPC IPC(8): A61K36/8969A61P39/06A61P3/10A61P37/02A61P35/00
CPCA61K36/8969A61K2236/15A61K2236/17A61K2236/333A61K2236/55
Inventor 沈玉平张祖姣黄光文胡克坚
Owner HUNAN UNIV OF SCI & ENG
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