Improved device for production of 3-amino-1-adamantanol

Abstract

The invention belongs to the field of chemical production, and in particular relates to an improved device for production of 3-amino-1-adamantanol. The improved device for the production of 3-amino-1-adamantanol comprises a reaction liquid storage tank, a magnetic pump and a reaction kettle with stirring paddles which are connected in sequence through a liquid guiding pipe; an ultrasound device is arranged between the reaction liquid storage tank and the magnetic pump; the ultrasonic device comprises a box body, an ultrasonic vibration plate arranged inside the box body and an ultrasonic generator connected with the ultrasonic vibration plate and arranged outside the box body; the inlet end of the box body is connected with the bottom of the reaction liquid storage tank, and the outlet end of the box body is connected with the magnetic pump. According to the invention, the ultrasonic vibration plate of the ultrasound device is used for vibrating and shattering bubbles and then a reaction liquid flows into the magnetic pump, and is pumped into the top of the reaction kettle by the magnetic pump, so that the phenomenon of the bubble-inclusion liquid can be greatly reduced; the single impurity content of the finished 3-amino-1-adamantanol is lowered below 0.3%, so that the content of the product is increased.

Description

technical field [0001] The invention belongs to the field of chemical production, and in particular relates to an improved device for producing 3-amino-1-adamantanol. Background technique [0002] Since the beginning of the 21st century, the latest diabetes treatment drug dipeptidyl peptidase (DPP-IV) inhibitor has gradually emerged, breaking the monopoly of insulin, sulfonylureas, biguanides and other drugs. Most of these drugs use 3-aminoadamantanol or its derivatives as intermediates. However, the patents of the original research are close to expiration, and there are many applications for imitation one after another. The demand for 3-amino-1-adamantanol as a key raw material is very large. [0003] In the production of 3-amino-1-adamantanol in the prior art, first add concentrated sulfuric acid to the reaction liquid storage tank, and at the same time slowly add amantadine hydrochloride, and pass in frozen water to keep the temperature below 20°C, stir evenly, and slowl...

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Problems solved by technology

[0006] The purpose of the present invention is to overcome the disadvantage that the bubbles produced in the production process of the prior art bring in a lot of impurities, resulting in the high content of 3-amino-1-adamantanol, and provide a method for producing 3-amino-1- Improved device for adamantanol

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