Ointment for photochemical adjuvant therapy and preparation method and application thereof

An adjuvant therapy and photochemical technology, applied in the directions of non-active ingredients medical preparations, medical preparations containing active ingredients, antiviral agents, etc. The effect of chapped, low recurrence rate, and prevention of skin burns

Inactive Publication Date: 2016-09-28
金新
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Photosensitizers (photochemotherapeutic agents) in the prior art are not always very satisfactory for photochemotherapy, the probability of relapse is extremely high in a short period of time, and the stability of photochemotherapeutic agents is not very good during storage before use. Therefore need improved photochemotherapeutic agent, improve the effect of adjuvant therapy, the present invention aims at solving this technical problem, provides a kind of ointment for photochemical adjuvant therapy and its preparation method and application

Method used

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  • Ointment for photochemical adjuvant therapy and preparation method and application thereof
  • Ointment for photochemical adjuvant therapy and preparation method and application thereof
  • Ointment for photochemical adjuvant therapy and preparation method and application thereof

Examples

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Comparison scheme
Effect test

Embodiment 1

[0020] An ointment for photochemical adjuvant therapy, said ointment is processed by the following components by weight: 5 parts of carbomer, 4 parts of glycerin, 12 parts of ethyl p-hydroxybenzoate, 1 part of methyl 5-aminolevulinate 1 part, 1 part of medicinal essence, 20 parts of ointment base, said ointment base is an equal proportion mixture of methyl cellulose and polyethylene glycol 300;

[0021] The preparation method is carried out as follows: (a) 5-aminolevulinic acid methyl ester pretreatment: make the 5-aminolevulinic acid methyl ester of formula quantity into liposome, add 5-aminolevulinic acid methyl ester in the process of preparing liposome -Aminolevulinic acid methyl ester 0.01% reduced glutathione, the purity of glutathione is more than 98.0%, to avoid the decomposition of 5-aminolevulinic acid methyl ester, and can greatly extend the shelf life of the ointment;

[0022] (b) The carbomer, glycerin, ethyl p-hydroxybenzoate, medicinal essence and ointment matri...

Embodiment 2

[0024] An ointment for photochemical auxiliary treatment, said ointment is processed from the following components by weight: 8 parts of carbomer, 8 parts of glycerin, 16 parts of ethyl p-hydroxybenzoate, 10 parts of methyl 5-aminolevulinate part, 3 parts of medicinal essence, 40 parts of ointment base, and described ointment base is carboxymethyl cellulose;

[0025] The preparation method is carried out as follows: (a) 5-aminolevulinic acid methyl ester pretreatment: make the 5-aminolevulinic acid methyl ester of formula quantity into liposome, add 5-aminolevulinic acid methyl ester in the process of preparing liposome - 0.02% of aminolevulinic acid methyl ester reduced glutathione, the purity of glutathione is more than 98.0%, to avoid the decomposition of 5-aminolevulinic acid methyl ester, and can greatly extend the shelf life of the ointment;

[0026] (b) The carbomer, glycerin, ethyl p-hydroxybenzoate, medicinal essence and ointment matrix in the formula amount are mixed...

Embodiment 3

[0028] An ointment for photochemical auxiliary treatment, said ointment is processed by the following components in parts by weight: 6 parts of carbomer, 5 parts of glycerin, 15 parts of ethyl p-hydroxybenzoate, 5 parts of methyl 5-aminolevulinate 2 parts, 2 parts of medicinal essence, 30 parts of ointment base, described ointment base is the mixture of methylcellulose and the polyethylene glycol of molecular weight 6000 by mass ratio 1:2;

[0029] The preparation method is carried out as follows: (a) 5-aminolevulinic acid methyl ester pretreatment: make the 5-aminolevulinic acid methyl ester of formula quantity into liposome, add 5-aminolevulinic acid methyl ester in the process of preparing liposome - Reduced glutathione with 0.015% aminolevulinic acid methyl ester quality, the purity of glutathione is more than 98.0%, to avoid the decomposition of 5-aminolevulinic acid methyl ester, and can greatly extend the shelf life of the ointment;

[0030] (b) The carbomer, glycerin, ...

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PUM

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Abstract

The invention relates to a medical ointment, in particular to an ointment for photochemical adjuvant therapy and a preparation method and application thereof. The ointment is prepared from, by weight, 5-8 parts of Carbomer, 4-8 parts of glycerol, 12-16 parts of ethyl p-hydroxybenzoate, 1-10 parts of 5-methyl aminolevulinate, 1-3 parts of medical essence and 20-40 parts of ointment matrix. The ointment has the advantages that when the ointment is used for photochemical adjuvant therapy, the treatment effect is good; after patients suffering from acne or condyloma acuminate use the ointment for adjuvant therapy, the relapse rate is extremely low. By means of the preparation method of the ointment, processing efficiency is high, product quality is stable, controllability is good, and cost is low.

Description

technical field [0001] The invention relates to a medical ointment, in particular to an ointment for photochemical auxiliary therapy and its preparation method and application. Background technique [0002] Photochemotherapy, or photodynamic therapy, is a technique used to treat various skin or other epithelial or mucosal abnormalities, especially cancerous or precancerous lesions and certain non-malignant lesions such as acne, genital warts. Photochemotherapy involves the application of a photosensitizer to an affected part of the body followed by light exposure to activate the photosensitizer and convert it into a cytotoxic form that kills the affected cells or reduces their proliferative potential. [0003] Photosensitizers (photochemotherapeutic agents) in the prior art are not always very satisfactory for photochemotherapy, the probability of relapse is extremely high in a short period of time, and the stability of photochemotherapeutic agents is not very good during st...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K9/06A61K47/18A61K47/10A61K47/38A61P17/10A61P17/12A61P31/20A61P17/16A61P17/02
CPCA61K9/0014A61K9/06A61K41/0038A61K47/10A61K47/183A61K47/38
Inventor 金新
Owner 金新
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