Aspartate-leucine copolymer modified paramagnetism metal complex as well as preparation method and application thereof

A technology of leucine copolymer and paramagnetic metal, which is applied in the field of paramagnetic metal complexes and its preparation, can solve the problems of high dosage and low targeting of magnetic resonance contrast agents, and achieve low dosage and stable aqueous solution sex, reducing the effect of accumulation
CN105963720AInactive Publication Date: 2016-09-28CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
Publication Date
2016-09-28
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses an aspartate-leucine copolymer modified paramagnetism metal complex as well as a preparation method and application thereof, belongs to the technical field of contrast agents, and solves the technical problems in the prior art that a magnetic resonance contrast agent is lower in targeting and high in dosage so as to further improve the relaxation efficiency, imaging contrast ratio, definition and sensitivity of the contrast agent. The structural formula of the metal complex is shown in the formula I (refer to the description), wherein z is an integer ranging from 1 to 1000, x is an integer ranging from 1 to 1000, y is an integer ranging from 1 to 1000, and M<m+> refers to paramagnetism metal ions. The metal complex can be used as a magnetic resonance imaging contrast agent which has excellent stability, water-solubility and relaxation efficiency, also has excellent targeting to a liver, and is higher in imaging contrast ratio and definition; the dosage lower limit of the metal complex is only 0.001 mmol / kg.
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Description

technical field

[0001] The invention belongs to the technical field of contrast agents, and in particular relates to a paramagnetic metal complex modified by an aspartic acid-leucine copolymer and a preparation method and application thereof. Background technique

[0002] Magnetic resonance imaging (magnetic resonance imaging, MRI) technology is another medical imaging technology after X-ray CT. Magnetic resonance imaging technology can image organisms from various angles, has very high temporal resolution and spatial resolution, and can present complete and clear anatomical images, and has been widely used in clinical diagnosis.

[0003] Magnetic resonance imaging contrast agents are compounds used to shorten imaging time, enhance contrast, and improve imaging contrast and clarity. About 50% of magnetic resonance imaging requires the use of magnetic resonance imaging contrast agents. MRI contrast agents do not generate signals by themselves, but improve the imaging contras...

Claims

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