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A kind of preparation method of artificial load-bearing cartilage hydrogel

A hydrogel and cartilage technology, applied in prosthesis, tissue regeneration, medical science and other directions, can solve the problems of reduced mechanical properties and recoverable properties of polymeric network hydrogels, and achieve excellent performance, wide source of raw materials, and low price. Effect

Active Publication Date: 2019-04-02
BEIJING FORESTRY UNIVERSITY
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Problems solved by technology

[0004] Aiming at the problem that the polymeric network of hydrogels synthesized by traditional methods is easily destroyed under physiological conditions, resulting in the reduction of hydrogel mechanical properties and recoverable properties, an object of the present invention is to provide a method for preparing hydrogels by microwave-assisted heating. The hydrogel prepared by this method not only maintains high toughness, ductility, and mechanical strength under physiological conditions, but also maintains the stability of its own shape and has good self-recovery properties

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  • A kind of preparation method of artificial load-bearing cartilage hydrogel
  • A kind of preparation method of artificial load-bearing cartilage hydrogel
  • A kind of preparation method of artificial load-bearing cartilage hydrogel

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[0040] In the preparation method according to the present invention, the high polymer PVA and PVP are used as raw materials, and the PVA and PVP are first prepared into a solution, and then the PVA solution and the PVP solution are mixed into a precursor solution under acidic conditions according to a certain ratio, and the React under assisted heating conditions, and finally transfer the reaction solution to room temperature for cooling to obtain a stable transparent hydrogel. This process does not require any complicated experimental equipment, and does not add any cross-linking agent, organic solvent, initiator and UV-induced conditions. , the components form a uniform homogeneous network structure through self-assembly, endowing the hydrogel with high mechanical properties and recoverability, green and pollution-free, simple process, and convenient operation. It is an efficient, fast and environment-friendly preparation of artificial load-bearing cartilage hydrogel glue met...

Embodiment 1

[0049] 1) Add 30g of PVA granules (PVA17-88, molecular weight 170,000-220,000, degree of alcoholysis about 88%, Sinopharm Chemical Reagent Co., Ltd.) into 345mL deionized water, stir magnetically, and heat at 80°C for 15min , the mass percentage concentration that obtains polyvinyl alcohol is the PVA solution of 8%;

[0050] 2) Add 5g of PVP powder (PVP powder K-30, molecular weight 10,000-70,000, Xilong Chemical Co., Ltd.) into 20mL of deionized water and disperse for 15min under ultrasonic conditions to prepare the mass percentage concentration of polyvinylpyrrolidone in the solution 20% PVP solution;

[0051] 3) Preparation of precursor solution

[0052] Dissolve the PVA obtained in step 1) and the PVP solution obtained in step 2) in a ratio of 7:3 by volume, mix and stir evenly, and then add sulfuric acid with a mass percentage concentration of 10% accounting for 1% of the volume of the mixed solution to obtain a precursor solution;

[0053] 4) Microwave assisted heatin...

Embodiment 2

[0057] The artificial load-bearing cartilage hydrogel (PVP-3) was prepared according to the same preparation steps as in Example 1, except that the mass percent concentration of the PVP solution in step 3) was changed to 3%.

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Abstract

The invention relates to a preparation method of artificial load-bearing hydrogel for cartilage. The artificial load-bearing hydrogel for cartilage has good mechanical properties and self-recovery performance in a physiological condition. The preparation method of the hydrogel employs PVA and PVP as reactants; cross-linking agents, organic solvents and initiators are not added; UV induction is not used, and the hydrogel product is obtained. The preparation method has the advantages of wide raw material sources, cheap price, and reduced production cost; and the hydrogel is good for promotion and usage in biomedicine.

Description

technical field [0001] The present invention relates to a preparation method of artificial load-bearing cartilage hydrogel, the artificial load-bearing cartilage hydrogel prepared by the method can maintain high mechanical properties and self-restoration under physiological conditions, in particular to a microwave-assisted heating self-assembly synthesis Preparation method of artificial load-bearing cartilage hydrogel. Background technique [0002] Polymer hydrogel is composed of a three-dimensional polymer cross-linked network and a large amount of water. Since hydrogel contains a large amount of water and is particularly soft, similar to human tissue, hydrogel is more and more popular as a substitute for human tissue. people's attention. At present, the mechanical strength, ductility, toughness, and recoverability of hydrogels are not satisfactory, so researchers are looking for more perfect designs to synthesize hydrogels that can be used for tissue replacement. As prop...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/52A61L27/50A61L27/26C08J3/075C08J3/28C08J3/24C08L29/04C08L39/06
CPCA61L27/26A61L27/50A61L27/52A61L2430/06C08J3/075C08J3/24C08J3/28C08J2329/04C08J2339/06C08L29/04C08L39/06
Inventor 马明国刘艳军刘姗付连花孟玲燕
Owner BEIJING FORESTRY UNIVERSITY
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