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Heterogeneous liquid settlement automatic-monitoring method and device

An automatic monitoring and heterogeneous technology, applied in the field of medicine and chemical industry, can solve the problems of large settling cycle time span, inability to meet the precise quantification of small/trace samples, long-term measurement requirements, lack of quantitative kinetic analysis, etc.

Pending Publication Date: 2016-10-05
SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The existing methods for determining the kinetic process of sedimentation basically stay at artificial semi-quantitative observation and trend comparison, lacking quantitative kinetic analysis. In practical applications, the sedimentation cycle time span of different systems is large, and the sampling intervals of readings are different. When there are too many samples to be tested , the cost of manpower, time and other resources is high, and the large error of manual reading directly affects the accuracy of the result
Unable to meet the needs of small / trace samples, multi-batch parallel control, precise quantification, and long-term measurement in the process of formulation development

Method used

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  • Heterogeneous liquid settlement automatic-monitoring method and device
  • Heterogeneous liquid settlement automatic-monitoring method and device

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0122] Example 1 Heterogeneous Liquid Settlement Automatic Monitoring Equipment

[0123] Such as Figure 1A As shown, the settlement automatic monitoring equipment of the heterogeneous liquid in the present embodiment comprises:

[0124] A sample carrying device 1, the sample carrying device 1 is used to place a container containing a sample to be tested, wherein the sample to be tested is a heterogeneous liquid that can settle; an image acquisition device 2, the image acquisition device 2 is set For collecting the image information of the sample; the control device 3, the control device 3 is configured to control the work of the image acquisition device 2; and the data processing device 4, the data processing device 4 is configured to It is used to identify the boundary line of the liquid level in the image information, and further identify the change of the boundary line of the liquid level with time. The data processing device described in this embodiment is a computer.

...

Embodiment 2

[0139] Embodiment 2 Settlement behavior monitoring

[0140] The settling (downward) behavior of the sample (microcrystalline cellulose and colloidal microcrystalline cellulose mixed in a certain ratio) in the standard test tube (flat-bottomed test tube) was monitored. By using the experimental device and method for monitoring, accurate sedimentation curves and sedimentation kinetic equations can be obtained.

[0141] Step 1: Using the heterogeneous liquid sedimentation automatic monitoring device in Example 1, put the liquid to be tested into a flat-bottomed test tube, adjust the brightness of the light source for the best imaging effect; set the image acquisition time interval and the number of acquisitions, and monitor .

[0142] Step 2: Combine figure 2 , after the collection is finished, read in all the pictures, perform automatic image processing (grayscale), and extract the uniformity characteristic information (including test tube and background, clarification area i...

Embodiment 3

[0150] Embodiment 3 monitors the sedimentation (upward) behavior of Pickering milk in the vial

[0151] Monitor the settling (upward) behavior of the Pickering milk in the vial. The sample settles quickly (sedimentation is completed around 200s), the sample volume is small (the effective size in the vial is 150 pixels), and the liquid level sedimentation changes little, so manual reading cannot obtain an accurate sedimentation curve. Therefore, using this experimental device and method for monitoring, after the difference conversion, the conventional settlement curve (gradually decreasing) and its settlement kinetic equation can be obtained.

[0152] Step 1: Using the heterogeneous liquid sedimentation automatic monitoring device in Example 1, put the liquid to be tested into a flat-bottomed test tube, adjust the brightness of the light source to achieve the best imaging effect; set the time interval and collection quantity, and monitor.

[0153] Step 2: Combine Figure 9 , ...

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Abstract

The invention discloses a heterogeneous liquid settlement automatic-monitoring method and device and concretely discloses a heterogeneous liquid settlement automatic-monitoring device and a heterogeneous liquid settlement automatic-monitoring method using the device. The device comprises a sample bearing device, an image acquisition device, a control device and an optional data processing device. The device has a simple structure and can be operated easily. Compared with the traditional artificial measurement method, the method provided by the invention has the advantages of time saving, continuity, reliability and accuracy. The device and method have an important latent application value in the scientific research and production application fields of pharmaceutics, chemistry and chemical engineering, materials science and food processing.

Description

technical field [0001] The invention relates to the field of medicine and chemical industry, in particular to a method and equipment for monitoring the sedimentation of a heterogeneous liquid. Background technique [0002] Sedimentation refers to the movement of particles in a fluid to settle downward under the action of gravity, and generally refers to the sedimentation of solid particles in a liquid. The speed of sedimentation is related to factors such as particle size, particle density, fluid density and viscosity, temperature, and fluid motion state. In different fields and for different applications, surfactants, suspending agents, and stabilizers can be added. Agents, flocculants, coagulants, and deflocculants are used to adjust the settling characteristics of heterogeneous systems. The determination of the sedimentation kinetic process is of great significance in the fields of pharmacy, chemical industry, food and so on. [0003] In the field of pharmacy, heterogen...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N15/04
Inventor 张继稳殷宪振鹿晓龙伍丽李海燕
Owner SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI