A kind of functional nasal cavity hemostatic material and preparation method thereof

A hemostatic material, nasal cavity technology, applied in the field of biomedical materials, can solve the problems of long recovery period, increased patient discomfort, easy adhesion of wounds, etc., and achieves high bacteriostatic effect and significant hemostatic effect.

Active Publication Date: 2019-05-03
四川艾医生医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] 1) It does not have antibacterial properties, and there will be corruption and stench after using it for about 4 days, so it is necessary to use a fungicide alone to treat the affected area;
[0006] 2) The hemostatic effect of simple physical compression, the hemostatic mechanism is single, and the hemostatic effect is not ideal;
[0007] 3) It has no healing effect on nasal wounds, and the postoperative recovery period is long;
[0008] 4) The characteristic of becoming dry and hard during use increases the patient's discomfort;
[0009] 5) Due to the porous nature of the sponge, it is easy to adhere to the wound after use and it is easy to cause pain and damage when it is removed

Method used

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  • A kind of functional nasal cavity hemostatic material and preparation method thereof

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preparation example Construction

[0027] According to an exemplary embodiment of the present invention, the preparation method of the functional nasal cavity hemostatic material includes the following steps.

[0028] Step A:

[0029] In terms of mass percentage, 5-15% of chitosan derivatives, 2-10% of bioactive glass and the rest of water are uniformly mixed to obtain chitosan composite suspension.

[0030] Among them, bioactive glass exists in the form of powder, which has excellent surface activity, can promote the growth of growth factors, promote cell reproduction, and activate cell gene expression. It not only has a wide range of antibacterial effects, but also promotes soft tissue and Bone tissue grows and promotes wound healing. The bioglass synthesized in the prior art is mostly based on mesoporous bioglass, such as the mesoporous bioglass fiber material prepared by Chinese patent CN1887361A using a sol-gel method, and the bioglass mesoporous microstructure prepared by Chinese patent CN101314039A. ba...

Embodiment 1

[0043] In terms of mass percentage, 5% of chitosan derivatives, 3% of bioactive glass and the rest of water are evenly mixed to obtain chitosan composite suspension. Among them, after mixing, perform static negative pressure degassing and defoaming at -0.1MPa, and use an ultrasonic disperser to continuously stir to form a uniform and stable suspension. The composition of the bioactive glass is 44% SiO 2 , 5% P 2 o 5 , 22% Na 2 O, the CaO of 25%, the MgO of 3% and the ZnO of 1%, utilize the mode of high-pressure atomization spraying to spray the chitosan composite suspension that makes on the polyvinyl alcohol sponge blank and on the polyvinyl alcohol sponge blank A composite functional coating containing chitosan and bioactive glass is formed, dried, compressed, packaged, and sterilized to obtain an effective nasal cavity hemostatic material, which is used as the 1# sample.

Embodiment 2

[0045] In terms of mass percentage, 10% of chitosan derivatives, 5% of bioactive glass and the rest of water are uniformly mixed to obtain chitosan composite suspension. Among them, after mixing, perform static negative pressure degassing and defoaming at -0.08MPa, and use an ultrasonic disperser to continuously stir to form a uniform and stable suspension. The composition of the bioactive glass is 44% SiO 2 , 5% P 2 o 5 , 22% Na 2 O, 25% CaO, 3% MgO and 1% ZnO. Utilize the mode of high-pressure atomization spraying to spray the prepared chitosan composite suspension on the polyvinyl alcohol sponge blank and form a composite functional coating containing chitosan and bioactive glass on the polyvinyl alcohol sponge blank, dry, Compress, pack and sterilize to obtain the effective nasal cavity hemostatic material, which is used as the 2# sample.

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Abstract

The invention discloses a functional nasal cavity hemostatic material and a preparation method thereof. The preparation method comprises the following steps: uniformly mixing the following materials in percentage by mass: 5 percent of chitosan derivate, 2 percent to 10 percent of bioactive glass and the balance of water, so as to obtain chitosan mixed suspension; spraying the chitosan mixed suspension on a polyvinyl alcohol sponge blank in a high-pressure atomization and spraying manner and forming a composite functional coating containing chitosan and the bioactive glass on the polyvinyl alcohol sponge blank; drying, compressing and packaging, and sterilizing to obtain the functional nasal cavity hemostatic material. The functional nasal cavity hemostatic material is prepared by adopting the preparation method of the functional nasal cavity hemostatic material. The composite functional coating containing the chitosan and the bioactive glass is added to the surface of a polyvinyl alcohol sponge base material through applying a high-pressure atomization and spraying process, so as to prepare the functional nasal cavity hemostatic material which has remarkable lubrication, moisture-keeping and hemostatic effects and relatively high bacteria-inhibiting effect, can promote the healing of wounds and is comfortable and convenient to use.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, and more specifically relates to a functional nasal cavity hemostatic material with remarkable hemostatic effect and capable of promoting wound healing and a preparation method thereof. Background technique [0002] The advantages of the traditional nasal hemostatic material, vaseline gauze, are clear hemostatic effect, simple manufacture, cheap price, and effective mechanical compression and support. Discomfort, after stuffing, the patient's nasal cavity and head pain symptoms are severe. If the extraction is early, the nasal cavity will bleed a lot; Collapse, shock, etc. [0003] Compared with traditional vaseline gauze, polyvinyl alcohol sponge has obvious advantages, but it still has the problems of dryness and poor lubricity. It is easy to cause discomfort to patients and cause certain damage to nasal mucosa during insertion and removal. , It often takes a long time to pack (f...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/722A61L15/28A61L15/24A61L15/18A61L15/42A61L15/46
CPCA61L15/18A61L15/24A61L15/28A61L15/42A61L15/46A61L2400/04C08L5/08C08L29/04
Inventor 高海利
Owner 四川艾医生医疗科技有限公司
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