Cu<2+> fluorescent probe based on benzoxazole structure and preparation method thereof

A benzoxazole and fluorescent probe technology, applied in the field of analytical chemistry, can solve problems such as poor selectivity and weak anti-interference ability, and achieve the effects of simple molecular structure, extremely anti-interference ability, and excellent linear range.

Inactive Publication Date: 2016-10-12
XUZHOU UNIV OF TECH
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Problems solved by technology

[0005] The technical problem to be solved by the present invention is that for Cu in the prior art 2+ The detection of fluorescent probes needs to participate in organic solvents and has poor selectivity and weak anti-interference ability. It provides a method that can selectively identify copper ions in aqueous solution, with strong anti-interference ability and wide linear range. , Cu with a low detection limit based on the benzoxazole structure 2+ Fluorescent probe and preparation method thereof

Method used

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  • Cu&lt;2+&gt; fluorescent probe based on benzoxazole structure and preparation method thereof
  • Cu&lt;2+&gt; fluorescent probe based on benzoxazole structure and preparation method thereof
  • Cu&lt;2+&gt; fluorescent probe based on benzoxazole structure and preparation method thereof

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Embodiment Construction

[0034] The technical solutions of the present invention will be further described below in conjunction with the accompanying drawings and through specific implementation methods.

[0035] A kind of Cu based on benzoxazole structure in this example 2+ Fluorescent probe, its molecular structure formula is as follows:

[0036]

[0037] A kind of Cu based on benzoxazole structure in this example 2+ The preparation method of fluorescent probe, its synthetic route is as follows:

[0038]

[0039] In this example, the preparation method specifically includes the following process steps:

[0040] Step A: Mix anthranilic acid and anthranilic phenol and grind them evenly, add the evenly ground mixture into polyphosphoric acid whose mass is 20 times that of the mixture, then react at 220°C under mechanical stirring, and the reaction time is 3h ;

[0041] Step B, after cooling the above reaction solution to above 60°C, pour the reaction solution into boiling water, and the volum...

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Abstract

Belonging to the field of analytical chemistry, the invention discloses a Cu<2+> fluorescent probe based on benzoxazole structure and a preparation method thereof. The molecular formula of the Cu<2+> fluorescent probe is C21H24N4O3, and the structural formula of the probe is shown as the specification. The preparation method of the fluorescent probe consists of: preparation of 2-(2'-aminophenyl)benzoxazole, preparation of an intermediate, and preparation of a final product. According to the Cu<2+> fluorescent probe based on the benzoxazole structure and the preparation method thereof provided by the invention, the Cu<2+> fluorescent probe has good selectivity to Cu<2+> in water, wide linearity range, and very strong anti-interference ability, thus being an ideal Cu<2+> sensor.

Description

technical field [0001] The invention relates to the field of analytical chemistry, in particular to a Cu compound based on a benzoxazole structure 2+ Fluorescent probes and methods for their preparation. Background technique [0002] Copper is an essential trace element in the human body and in the metabolism of nutrients in the life cycle. At the same time, due to its wide application in many industries, copper is also an important metal pollutant. When the concentration of copper ions is low, it It is a kind of nutrient substance for various organs, but the existence of excessive copper ions will be toxic to the human body, and it will also disturb the function of normal cells. Therefore, the balance of copper ions in the body is related to many major diseases such as: Menkes' syndrome, Parkinson's disease, Wilson's disease, prions, Alzheimer's disease, etc. The World Health Organization stipulates that the concentration of copper ions in daily drinking water should not ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D263/57C09K11/06G01N21/64
CPCC07D263/57C09K11/06C09K2211/1033C09K2211/1044G01N21/643G01N21/6486
Inventor 田林庄文昌周颖梅盛风涛李昭李靖顾越飞
Owner XUZHOU UNIV OF TECH
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