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Batilol solid preparation and preparation method thereof
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A technology of solid preparations and batyl alcohol, which is applied in the field of medicine, can solve problems such as unstable performance, achieve the effects of multiple absorption points, accelerated drug dissolution, and improved effectiveness
Inactive Publication Date: 2016-11-16
SHANGHAI SINE WANXIANG PHARMA +1
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[0004] The existing batyl alcoholdrug is used to treat leukopenia caused by various reasons, but due to the obvious influence of measurement, the clinical application needs to closely monitor the blood drug concentration and blood routine, and the performance is unstable
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Embodiment 1
[0036] The preparation of embodiment 1 squalanealcohol solid preparation
[0037] 1.1 Dosage of each component:
[0038]
[0039] 1.2 Adopt direct compression of powder, including the following steps:
[0040] A. Grind 30 parts of shark liver alcohol and pass through an 80 mesh sieve;
[0042] C, adopt equal increment method, first mix 1 part of menthol after sieving with 1 part of mannitol, add the remaining 7 parts of mannitol, mix well, obtain mixture a;
[0043] D. Add 15 parts of sodiumcarboxymethyl starch in mixture a, mix homogeneously, then add 8 parts of crospovidone, mix homogeneously to obtain mixture b;
[0058] The preparation of embodiment 2 squalane alcohol solid preparation
[0059] 2.1 Dosage of each component:
[0060]
[0061] 2.2 Preparation method: The powder is directly compressed into tablets, and the specific operation steps are the same as those in Example 1 to obtain the solid preparation of squalane alcohol with batch number GY1B, 20 mg / tablet.
[0062] 2.3 Preparation method: dry granulation and tableting were adopted, and the specific operation steps were the same as those in Example 1, and the solid preparation of shark liver alcohol with batch number GY2B was prepared, 20 mg / tablet.
Embodiment 3
[0063]The preparation of embodiment 3 squalane alcohol solid preparation
[0064] 3.1 Dosage of each component:
[0065]
[0066] 3.2 Preparation method: The powder is directly compressed into tablets, and the specific operation steps are the same as those in Example 1, and the solid preparation of squalane alcohol with the batch number of GY1C, 20 mg / tablet is obtained.
[0067] 3.3 Preparation method: dry granulation and tableting were used, and the specific operation steps were the same as those in Example 1, and the solid preparation of squalane alcohol with batch number GY2C was prepared, 20 mg / tablet.
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Abstract
The invention discloses a batilol solid preparation and a preparation method thereof. The batilol solid preparation consists of the following components in parts by mass: 30-50 parts of batilol, 10-30 parts of microcrystallinecellulose, 10-30 parts of lactose, 5-10 parts of mannitol, 5-10 parts of cross-linked polyvinylpolypyrrolidone, 5-20 parts of sodiumcarboxymethyl starch, 0.5-2 parts of menthol, 0.2-1 part of superfine silica powder and 0.2-1 part of magnesiumstearate. The batilol solid preparation, which is prepared by virtue of powder direct tableting and dry granulation and tableting processes, disclosed by the invention is convenient to take, good in taste, rapid in dissolution and release and high in bioavailability, and the batilol solid preparation is especially suitable for patients having difficulty in swallowing; and the preparation method is simple and feasible, simple in process steps, low in cost and suitable for wide popularization and application.
Description
technical field [0001] The invention relates to the technical field of medicine, in particular to a squalanealcohol solid preparation and a preparation method thereof. Background technique [0002] Leukopenia and agranulocytosis are common and frequently-occurring diseases of the blood system in internal medicine. The causes of the disease can be caused by physical and chemical factors such as drugs (such as benzene poisoning) or infections and other diseases, some of which are unknown. Especially in the treatment process of many tumor diseases, most of them need to use chemotherapy or radiotherapy, both of which will kill a large number of hot body leukocytes, which are the important causes of this disease. Many tumor patients are often caused by leukopenia. Can not continue to receive chemotherapy or radiotherapy, so as to lose the opportunity for treatment, resulting in the development and deterioration of the tumor. Therefore, the problem of leukopenia during radiother...
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