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Pharmaceutical composition of disopyramide phosphate and application of pharmaceutical composition in biomedicine

A kind of technology of disopyramide phosphate and composition, applied to pharmaceutical composition and its application field in biomedicine, can solve the problems such as the reports on the correlation between disopyramide phosphate and its pharmaceutical composition and epilepsy, and achieve treatment The effect of increasing the effect

Inactive Publication Date: 2016-11-16
丁俣汀
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] So far, there has been no report on the correlation between disopyramide phosphate and its pharmaceutical composition and epilepsy

Method used

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  • Pharmaceutical composition of disopyramide phosphate and application of pharmaceutical composition in biomedicine
  • Pharmaceutical composition of disopyramide phosphate and application of pharmaceutical composition in biomedicine
  • Pharmaceutical composition of disopyramide phosphate and application of pharmaceutical composition in biomedicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Example 1: Compound (I) Separation Preparation and Structure Confirmation

[0019] Separation method: (a) Pulverize Folium Folium (2kg), extract with 65% ethanol under heat reflux (20L×3 times), combine the extracts, concentrate until no alcohol smell (4L), and then use petroleum ether (4L×3 times), ethyl acetate (4L × 3 times) and water-saturated n-butanol (4L × 3 times) were extracted to obtain petroleum ether extract, ethyl acetate extract and n-butanol extract respectively; (b) step ( a) The n-butanol extract is removed with AB-8 macroporous resin, first eluted with 10% ethanol for 12 column volumes, then with 70% ethanol for 15 column volumes, collected 70% eluate, and reduced Concentrate under pressure to get 70% ethanol elution concentrate; (c) in step (b), 70% ethanol elution concentrate is separated with normal phase silica gel, and the volume ratio is 50:1 (8 column volumes), 25:1 successively (8 column volumes), 15:1 (8 column volumes) and 5:1 (10 column vol...

Embodiment 2

[0023] Embodiment 2: pharmacological action

[0024] In this example, rats were intraperitoneally injected with 6 million U / kg of penicillin to make an epilepsy model, and to observe the effect of drugs on epilepsy.

[0025] 1. Materials and methods

[0026] 1.1 Animals

[0027] 90 Wistar rats, half male and half male, weighing 120±20 g, were provided by the Experimental Animal Center of Heilongjiang University of Traditional Chinese Medicine.

[0028] 1.2 Reagents and samples

[0029] Disopyramide phosphate was purchased from China Institute for the Control of Pharmaceutical and Biological Products. Compound (I) is self-made, and the preparation method is shown in Example 1. Phenytoin: produced by Tianjin Lisheng Pharmaceutical General Factory; penicillin: produced by Harbin Pharmaceutical General Factory; urethane: produced by Harbin Pharmaceutical General Factory.

[0030] 1.3 Instruments

[0031] LMB-2B two-channel physiological recorder: produced by Chengdu Instrument...

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Abstract

The invention discloses a pharmaceutical composition of disopyramide phosphate and its application in biomedicine. The pharmaceutical composition of disopyramide phosphate provided by the invention contains disopyramide phosphate and a novel natural product compound (I ), when disopyramide phosphate and compound (I) act alone, they have a therapeutic effect on epilepsy; when disopyramide phosphate and compound (I) act in combination, the therapeutic effect on epilepsy is further improved, and can be developed into a drug for treating epilepsy, Compared with the prior art, it has outstanding substantive features and remarkable progress.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to a new application of disopyramide phosphate, in particular to a pharmaceutical composition of disopyramide phosphate and its application in biomedicine. Background technique [0002] Disopyramide phosphate is a class Ia antiarrhythmic drug. Its electrophysiology and hemodynamics are similar to quinidine, which can inhibit the influx of fast sodium ions, prolong the action potential and effective refractory period, reduce the conduction velocity of the atrium and additional bundles, reduce the self-discipline of myocardial conduction fibers, and inhibit the atrium and Excitability of ventricular muscle, reducing myocardial contractility. In addition, it has obvious anticholinergic effect. [0003] So far, there has been no report on the correlation between disopyramide phosphate and its pharmaceutical composition and epilepsy. Contents of the invention [0004] The object of the prese...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4402A61K31/352C07D493/18A61P25/08
CPCA61K31/4402A61K31/352A61K36/195A61K36/315A61K36/704A61K36/855C07D493/18
Inventor 丁俣汀
Owner 丁俣汀