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Amoxicillin soluble powder and preparation method thereof

A technology of amoxicillin and amoxicillin trihydrate, applied in the field of amoxicillin soluble powder and its preparation, can solve the problems of amoxicillin failure, easy ring opening, etc. The effect of easy operation of the process

Active Publication Date: 2016-12-07
CHINANIMAL NANJING VETERINARY DRUGS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, as the antibacterial active group of amoxicillin in vivo, the β-lactam ring in the amoxicillin molecule is stable under acidic conditions, but it is easy to open the ring in an alkaline environment, resulting in the failure of amoxicillin

Method used

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  • Amoxicillin soluble powder and preparation method thereof
  • Amoxicillin soluble powder and preparation method thereof
  • Amoxicillin soluble powder and preparation method thereof

Examples

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Effect test

Embodiment 1

[0033] The amoxicillin soluble powder of the present embodiment, its prescription composition and preparation process are as follows:

[0034]

[0035] (1) The raw material amoxicillin trihydrate is micronized, and jet milling is used to obtain drug particles with a particle diameter of 50-100 microns.

[0036] (2) Grinding and sieving anhydrous sodium phosphate, sodium hexametaphosphate, sucrose, and micronized silica gel, with a mesh number of 80-100 mesh.

[0037] (3) Mixing: Mix the materials obtained in (1) and (2), the mixing time is 40 minutes, mix well and set aside.

[0038] (4) Subpackage: Subpackage and inspect the materials obtained in (3) to obtain the finished product of amoxicillin soluble powder.

Embodiment 2

[0040] The amoxicillin soluble powder of the present embodiment, its prescription composition and preparation process are as follows:

[0041]

[0042] (1) The raw material amoxicillin trihydrate is micronized, and jet milling is used to obtain drug particles with a particle diameter of 50-100 microns.

[0043] (2) Grinding and sieving anhydrous sodium carbonate, sodium hexametaphosphate, sucrose, and micropowder silica gel, the mesh number of which is 80-100 mesh.

[0044] (3) Mixing: Mix the materials obtained in (1) and (2), the mixing time is 40 minutes, mix well and set aside.

[0045] (4) Subpackage: Subpackage and inspect the materials obtained in (3) to obtain the finished product of amoxicillin soluble powder.

Embodiment 3

[0047] The amoxicillin soluble powder of the present embodiment, its prescription composition and preparation process are as follows:

[0048]

[0049] (1) The raw material amoxicillin trihydrate is micronized, and jet milling is used to obtain drug particles with a particle diameter of 50-100 microns.

[0050] (2) Grinding and sieving anhydrous sodium phosphate, sodium hexametaphosphate, sucrose, and micronized silica gel, with a mesh number of 80-100 mesh.

[0051] (3) Mixing: Mix the materials obtained in (1) and (2), the mixing time is 40 minutes, mix well and set aside.

[0052] (4) Subpackage: Subpackage and inspect the materials obtained in (3) to obtain the finished product of amoxicillin soluble powder.

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Abstract

The invention relates to amoxicillin soluble powder and a preparation method thereof. The amoxicillin soluble powder is composed of the following components, by weight: 10-60 parts of amoxicillin trihydrate, 3-20 parts of a cosolvent, 3-30 parts of a stabilizer, 0.4-85 parts of a filler, and 0.05-1 part of a glidant, wherein the stabilizer is sodium hexametaphosphate. The preparation method comprises: micronizing the raw material, amoxicillin trihydrate, crushing and screening the cosolvent, the stabilizer, the filler and the glidant respectively, mixing materials, subpackaging, and checking to obtain the finished amoxicillin soluble powder. The amoxicillin soluble powder is high in solubility and good in stability, can inhibit hydrolysis of drugs and is beneficial to practical application.

Description

technical field [0001] The invention relates to amoxicillin soluble powder and a preparation method thereof, which are suitable for the field of veterinary medicine. Background technique [0002] As far as the inventor knows, amoxicillin belongs to semi-synthetic penicillin β-lactam antibiotics, has strong bactericidal effect, and has a wide antibacterial spectrum, and is effective against most pathogenic Gram-positive and Gram-negative bacteria. There is a strong anti-killing effect. As a common antibiotic for humans and animals, amoxicillin is rapidly absorbed orally, and has good preventive and therapeutic effects on upper respiratory tract infections, urinary system infections, and intestinal infections. [0003] The water solubility of amoxicillin at room temperature is about 1 mg / ml, which is a slightly soluble substance. Since the amoxicillin molecule contains a carboxyl group, the alkaline environment can greatly increase the solubility of amoxicillin. [0004] Ho...

Claims

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Application Information

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IPC IPC(8): A61K9/14A61K31/43A61K47/02A61P31/04
CPCA61K9/0095A61K9/143A61K31/43
Inventor 徐瑞华马小平胡娟戴银娣
Owner CHINANIMAL NANJING VETERINARY DRUGS
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